Endocrine Abstracts

Introduction: Maintenance immunosuppressive regimens after renal transplantation (RTx) most often include prednisolone which may induce secondary adrenal insufficiency. Adrenal insufficiency is a potentially life-threatening side effect to glucocorticoid treatment due to the risk of acute adrenal crisis. We aimed to investigate the prevalence of prednisolone-induced adrenal insufficiency in RTx patients receiving long-term low-dose prednisolone treatment.<p class="abstext"...

Objective: Glucocorticoid-induced adrenal insufficiency is highly prevalent, but the clinical consequences are not fully understood. Therefore, the indication of adding stress dosages of glucocorticoid during ongoing anti-inflammatory glucocorticoid treatment remains unclear. The aim of this study was to determine the impact of adrenal function on health-related quality of life (HRQoL) in patients receiving ongoing low-dose prednisolone treatment.Methods...

Conventionally, an allosteric modulator is neutral in respect of efficacy and binds to a receptor site distant from the orthosteric site of the endogenous agonist. However, recently compounds being ago-allosteric modulators have been described i.e. compounds acting both as agonists on their own and as enhancers for the endogenous agonists in both increasing agonist potency and often providing additive efficacy - superagonism. The additive efficacy can also be observed with ago...

Objectives: There is limited knowledge of high-sensitivity C-reactive protein (CRP) levels among newly diagnosed T2D patients in the population-based setting, and of factors associated with elevated CRP.Methods: Measurements of CRP were performed in the first 1036 T2D patients in the nationwide DD2 project, enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We examined the number of T2D patients within CRP t...

Objectives: Elevated levels of serum alanine aminotransferase (ALAT) have been linked with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), insulin resistance and the metabolic syndrome in type 2 diabetes (T2D) patients. We examined ALAT levels in newly diagnosed T2D patients, and the factors associated with such elevation.Methods: Measurements of ALAT were performed in 1025 (43% women and 57% men) new T2D patients enrolle...

Although molecular research has contributed significantly to our knowledge of familial neurohypophyseal diabetes insipidus (FNDI) for more than a decade, the genetic background and the pathogenesis still is not understood fully. FNDI is, in 87 of 89 kindreds known, caused by mutations in the arginine vasopressin (AVP) gene, the pattern of which seems to be largely revealed as only few novel mutations have been identified in recent years. The mutation pattern, together with evi...

Few population-based data exist on the prevalence of the metabolic syndrome (MS) its components, and its association with subclinical inflammation and insulin resistance among patients newly diagnosed with type two diabetes (T2D).We examined the MS according to IDF criteria by linkage primary data (waist circumference, fasting blood glucose, and high-sensitivity C-reactive protein (CRP)) with variables from the Danish diabetes database for adults (blood ...

Incretin-based therapies, such as the injectable GLP-1 receptor agonists and orally administered DPP-4 inhibitors, have recently been introduced into clinical practice. At present, the GLP-1 receptor agonists need to be administered once or twice daily. Several once weekly GLP-1 receptor agonists are in phase 3 development. This review examines the efficacy, safety and perspective for the future of the once weekly GLP-1 receptor agonists: exenatide once weekly, taspoglutide, a...

Introduction: Pharmacological glucocorticoid (GC) treatment may cause iatrogenic adrenal insufficiency (GIA), although the prevalence and clinical implications are debated. With 3% of the Danish population redeeming prescriptions of systemic GC annually, the number of patients at risk is potentially extensive. Taken together, there is an unmet need for a prospective and unbiased assessment of the GIA prevalence.Materials and Methods: The data for this re...

Introduction: The aetiology of a diabetic foot ulcer is multifactorial. The three principal components that ascertain the likelihood of ulceration in a diabetic foot are peripheral neuropathy, repeated minor trauma and deformity. Aims:To find the prevalence of diabetes patients having the foot at risk using the Simplified 60-Second Diabetic Foot Screen tool (SSDFST).Objectives: To find out the diabetic foot at risk.1. To ascertain the dispersal of variou...