Endocrine Abstracts

Patient is a seventy year old Egyptian female with past medical history of coronary artery disease, systolic heart failure, chronic kidney disease stage 3, and a benign pheochromocytoma previously worked up at a neighboring hospital, who was admitted for dyspnea and subjective fever intermittently for the past two weeks. Chest x-ray revealed bilateral pulmonary infiltrates. She was treated for community acquired pneumonia. Four days after admission patient has worsening respir...

Endocrine tumour registry is a web-based system which is divided in several categories of endocrine tumours: pituitary adenomas, thyroid cancer, parathyroid tumours, adrenal and other types.The program is intended to give epidemiological data concerning the prevalence of each type, age and sex distribution, therapy and basic results of it. The centres involved are the medical universities and expertise centres in Romania, centres in which there are enoug...

Background and Aims: The concurrent presentation of Type 1 diabetes mellitus (T1DM) with other autoimmune disorders, notably autoimmune thyroiditis and celiac disease, has been substantiated in numerous studies. Established guidelines advocate for routine screenings for these disorders at the onset of T1DM diagnosis, followed by periodic evaluations — biennially for thyroid pathologies and every 2-5 years for celiac disease. This research endeavours to elucidate the preva...

Background and objective: One of the key features of thyroid gland cancer evaluated at palpation is the degree of firmness: malignant lesions tend to be much harder than benign ones. US elastography is combining the diagnostic advantages of high-frequency US examination and the accuracy of thyroid cancer diagnosis based on the lesion’s stiffness. The aim of our prospective study was to evaluate the elastographic appearance of thyroid gland tumours and to explore the sensi...

Childhood obesity is a highly prevalent, chronic, and progressive disease. While lifestyle therapy is the cornerstone of obesity treatment, this intervention is usually ineffective for achieving clinically significant and durable BMI reduction. The limitations of lifestyle therapy stem from the fact that this intervention does not address the underlying pathophysiology of obesity. Anti-obesity pharmacotherapy, in contrast, directly addresses the pathophysiology, thereby enhanc...

A 53-year-old caucasian female presented with tremor, palpitations, sweating, breathlessness and chest discomfort. Examination revealed a non-tender, large diffuse goitre and TFT showed an elevated T4 and undetectable TSH. Thyroid antibodies were elevated; 115 IU/ml (NR <35) and thyroid ultrasound confirmed diffuse vascular goitre. Patient was diagnosed with thyrotoxicosis with a likely aetiology of Grave’s disease.Carbimazole was com...

Introduction: MEN4 syndrome is a recently described form of MEN in patients with parathyroid and anterior pituitary tumors, which may also develop bronchial, gastric and pancreatic neuroendocrine tumors. In general, the patients present with clinical signs of primary hyperparathyroidism and simptoms caused by pituitary hormones hypersecretion or due to the tumor mass. However, clinical cases with the coexistence of pituitary tumors and pheochromocytoma are very rare described....

Introduction: Duchenne muscular dystrophy (DMD) is a genetic condition caused by mutations in the X-linked dystrophin-gene leading to muscle degeneration and early death in males.Since DMD is characterized by aggressive inflammation it is recommended the use of pharmacological treatment with corticosteroids (CS). Type-1 diabetes mellitus (T1DM) is one of the most common chronic diseases in childhood and is caused by insulin deficiency resulting from the autoimmune destruction ...

Nesidioblastosis is defined as a diffuse proliferation of primitive pancreatic islet cells budding from ductal epithelium. This condition can cause hypoglycaemia in infants as a result of mutations in the sulfonylurea receptor or in the anatomically linked potassium channel. In adults, this disease occurs independently from these genetic mutations.Case report: A 41-year-old male was referred to our center via emergency room with suspicion of an insulinom...

Introduction: We should consider testing for primary aldosteronism in the presence of hypertension and hypokalaemia, resistant hypertension, onset of hypertension at a young age (<20 year), severe hypertension and whenever considering secondary hypertension.Case report: We presented the case of a 38 years old woman who was admitted in the National Institute of Endocrinology C.I. Parhon Bucharest for the evaluation of high blood pressure. She has high...