Endocrine Abstracts

Introduction: Lithium is a common pharmacological intervention for the treatment of bipolar affective disorder and is advocated by clinical practice guidelines (NICE 2021). Blood test monitoring is essential for management of lithium treatment and UK NICE guidance recommends 6-monthly serum testing of thyroid function. We here examine conformity to guidance and the consequences of monitoring outside these intervals.Methods: We extracted serum lithium/thy...

Introduction: Bariatric surgery is now a common surgical procedure for weight management recommended by NICE. Complications such as dumping syndrome, micronutrient deficiencies and cholelithiasis are well documented in the literature. Here we discuss the lesser reported complication of adrenal insufficiency seen in three patients following roux-en-y gastric bypass surgery for morbid obesity.Case reports: Three patients were seen in the outpatient clinic ...

Pituitary hormones have long been thought solely to regulate single targets. Challenging this paradigm, we found that both anterior and posterior pituitary hormones, including FSH, had other functions in physiology. We have shown that FSH regulates skeletal integrity, and, more recently, find that FSH inhibition reduces body fat and induces thermogenic adipose tissue in wild type mice, phenocopying genetic haploinsufficiency for the FSH receptor. A polyclonal antibody raised a...

Introduction: The sensitivity of tissues to thyroid hormones can be impaired rarely, either due to the genetic anomalies of the thyroid hormone metabolism and transport. Consequently, the relative triiodothyronine(T3), thyroxine(T4), and reverseT3(rT3) levels get disturbed and different clinical manifestations ensue. Two recently admitted cases are briefly described.First Case: A 32 yrs old Saudi housewife, had been admitted to our hospital on 05.01.2023...

Introduction: Nasopharyngeal carcinoma is a rare entity with a predominant geographic distribution in North Africa, Arctic, Southern China and Southeast Asia. Case Presentation: 32 yrs old, single, Saudi, male, had presented to our hospital on 26.11.2022. He had 2 months history of undocumented fever, blackish oral lesions, anorexia and profound weight loss(20kgs). He had become fully dependent and bed-bound. No addictions, allergies or high risk behavio...

Introduction: Diabetes can involve the musculoskeletal system causing frozen shoulder, Dupuytren’s contracture, diabetic sclerodactyly, trigger finger, muscle infarction, diabetic amyotrophy, idiopathic lumbosacral radiculoplexus neuropathy, necrotizing fasciitis and many other complications. A case is described, who despite having multiple acute and chronic sequelae of diabetes, was successfully managed and discharged.Case Presentation: 54yrs old o...

IntroductionHypertension is a frequent finding amongst people having either Type1 or Type 2 diabetes. In Type 2 diabetes, hypertension is present in a great number of persons, at the time of diagnosis but it’s occurrence is low with the diagnosis of Type 1 diabetes.Case presentationA 34 years old Saudi male, non-smoker, had been following up at our University Diabetes Center since February, 2020. He had ...

IntroductionMetabolic syndrome is the concurrence of the metabolic risk factors for both diabetes and cardiovascular disease, namely, hypertension, hyperglycemia, dyslipidemia and abdominal obesity.Case presentationWe report a case of 59 years old morbidly obese, Saudi lady, who had been following up at our outpatient diabetes clinic, since last many years. She had Type2 diabetes for 34 yrs, hypertension, adv...

IntroductionPernicious anemia is an autoimmune cause of Vitamin B12 deficiency, that can occur as part of polyglandular adenopathy Type 3. According to one prospective serial study, it’s incidence was 2.3%in people ≥ 60 years of age, being more common in women than men. A case of polyglandular syndrome, most likely PGA-3, is being described. She had Type 1 diabetes, Hashimoto’s thyroiditis, vitiligo & pernicious anemia.<p class="a...

Background: The commonest etiology for the chronic kidney disease and end-stage renal disease, universally, is diabetes. Although, the histology of the kidney is the gold standard for diagnosing diabetic kidney disease, but in common practice it’s usually diagnosed clinically and through laboratory testing.Clinical Case: 43 yrs old Saudi house-wife was admitted on the 7th of February, 2024 with 5 months history of progressive pitting pedal edema, fa...