Endocrine Abstracts

Introduction: The aim of the study was to assess the function and immunogenicity of thyroid gland of patients undergoing chronic treatment with the opiate agonist Methadone.Material and methods: Cross-sectional, observational study included patients from 18 to 40 years of age undergoing chronic treatment with Methadone for at least 6 months. A total of 176 participants took part in the study. 140 patients were from five clinical programs in Bulgaria and ...

Dramatic improvements in cancer survival over the past four decades means that greater than 80% of children diagnosed with cancer can expect to survive for more than five years. For some cancers, such as acute lymphoblastic leukaemia and Hodgkin’s disease, cure rates exceed 90%. Currently, there are over 26000 young adults living in the UK, 600 000 across France, Italy, Switzerland, Netherlands and the Nordic countries and 363 000 in the US, who are survivors of childhood...

Our lifestyle habits and environmental exposures are typically considered to affect only our health (with the exception of pregnant mothers). Nevertheless, there is epidemiological evidence from human studies that adverse health consequences can also be observed in offspring and grand offspring (e.g. Roseboom et al., Molecular and Cellular Endocrinology, 2001). The mechanisms of trans- or inter-generational epigenetic inheritance are currently not known. We, and other...

Introduction: Hypercalcaemia accounts for 0.6% of all acute medical admissions1, with primary hyperparathyroidism and malignancy-associated hypercalcaemia contributing to 90% of these cases.Case Presentation: A 67-year-old female was initially seen in neurology clinic with a 3-year history of subtle word-finding difficulties, episodic confusion, and balance problems. On further probing, she reported constipation, polyuria and polydipsia, but h...

Introduction: Formation of immunological tolerance to self antigens is an important mechanism that prevents the development of autoimmune diseases.Methods: With the help of molecular genetic and immunofluorescence techniques we investigated the effects of experimental gestational diabetes (EGD) on the level of mRNA expression of autoimmune regulator Aire and differentiation features of Foxp3+ cells in mesenteric lymph nodes in the offspring of...

Introduction: Hypoparathyroidism is a rare endocrine disease with a prevalence of less than 40/100,000 people worldwide1. It has a variable presentation but can present with life-threatening arrhythmias or seizures.Case PresentationA 31-year-old male presented to our Emergency Department following a witnessed tonic-clonic seizure with no previous history of epilepsy. He was not on any regular medications and denied recreational drug use. Examination was largely unre...

Background: Bariatric surgery significantly aids weight loss, improves glycaemic control and/or induces remission in Type 2 Diabetes patients. However, the impact of bariatric surgery in Type 1 diabetes (T1D) patients is less well-understood. With an increasing prevalence of obesity within the T1D population, it is important to identify whether bariatric surgery improves glycaemic control and prevents future complications.Aim: To evaluate the effect on B...

Introduction: Diabetic Ketoacidosis (DKA) is a common complication of Type 1 Diabetes (T1DM), accounting for around 21% of all diabetes related admissions. It is a major source of morbidity and mortality amongst children with T1DM. Delayed diagnosis, shock, renal failure, cerebral oedema and sepsis remain problematic. The aim of this project was to compare local management to best practice as per the British Society for Paediatric Endocrinology and Diabetes (BSPED), and provid...

Introduction: Mesenteric lymph nodes (MLN) is a major transition point for recirculating lymphocytes of GALT. Homing of lymphocytes in MLN is regulated with adressin MAdCAM-1, chemokine receptors CXCR4 and CCR7. Sphingosine-1-phosphate receptors S1PR1 activate T-cell exit from MLN.Methods: We use RT-PCR method for investigating of mRNA expression levels of genes MAdCAM-1, CXCR4, CCR7 and S1PR in MLN of the offspring of rats with experimental gestational ...

A 68 yr old male with a history of type 2 diabetes presented with myalgia and girdle weakness affecting him on a frequent but episodic basis. Investigations confirmed Cyclical Cushing's Disease. Pituitary MRI was normal. Further investigations include bilateral inferior petrosal sinus sampling (BIPSS) which can help determine the origin of ACTH-dependent Cushing’s syndrome. After CRH-stimulation, a peak central to peripheral ACTH ratio of >3 suggests a pituitary ACTH ...