Endocrine Abstracts

Context: Adipose tissue distribution is closely related to metabolic disease risk. GH reduces visceral and total body adipose tissue mass, while inducing whole body insulin resistance.Objective: To assess the role of visceral adipose tissue and derived adipokines for the systemic insulin resistance and lipid metabolism, before and after treatment in acromegaly.Patients: Sixty-six adult patients with active acromegaly diagnosed betw...

Objective: Early puberty is associated with increased risk of subsequent cardiovascular disease. Low sex hormone-binding globulin (SHBG) levels are a feature of early puberty as well as conditions associated with increased cardiovascular risk. The aim of the present study was to evaluate SHBG as predictor of glucose metabolism and metabolic risk during puberty.Research design and methods: Cross-sectional study on 132 healthy Caucasian children and adoles...

Objective: Patients with acromegaly present increased insulin resistance despite reduced adipose tissue (AT) mass. Growth hormone (GH) stimulates lipolysis, but the role of AT as a metabolic factor in patients with acromegaly is still uncertain. Moreover, there is a need for better biomarkers of disease activity in acromegaly.Methods: RNA-sequencing was performed on paired subcutaneous AT (SAT) biopsies from patients (n=6) with active acromegaly...

Background: Long standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry including increased cortical bone thickness (CBT). However, a high prevalence and incidence of vertebral fractures has been reported. The aim of this study was to assess the course of cortical bone dimensions in the hip by comparing patients with acromegaly and clinically non-functioning pituitary adenomas (NFPA) at baseline and one year a...