Endocrine Abstracts

Introduction: Hyperparathyroidism (HPT) in children is rare with limited outcome measures post surgery.Methods: Retrospective case review of 26 (14M) children (<16 years) who underwent parathyroidectomies (PTx) between 1978 and 2011.Results: Twenty-six children (14M, 12F) included six neonates with neonatal severe HPT (NSHPT) and 20 older children with HPT (13 sporadic, 7 familial).All NSHPT neonates were...

Total pancreatectomy for chronic pancreatic pain is often deferred because it leaves the patient with unstable insulin-dependent diabetes. NICE (2008) has recently approved pancreatectomy with simultaneous islet autotransplantation and we here describe our first case. A 49-year-old female with a 6-year history of intractable, opioid requiring abdominal pain had become depressed to the point of suicide attempts. Imaging showed pancreatic atrophy and duct irregularity (subsequen...

Medullary thyroid cancer (MTC) accounts for 5–10% of all thyroid cancers and can be either sporadic (75%) or familial (25%). Familial MTC is associated with hereditary syndromes such as Multiple Endocrine Neoplasia (MEN) type 2A or 2B and Familial Medullary Thyroid Cancer (FMTC). Sporadic MTC most often present as thyroid nodule and fine needle aspiration cytology combined with elevated plasma calcitonin levels is diagnostic in about 90% of cases. Hereditary forms of MTC ...

Primary Hyperparathyroidism (PHPT) is, after diabetes and thyroid diseases, the third commonest endocrine disorder and its incidence and prevalence is rising globally. In the United Kingdom, the incidence of PHPT has been estimated to be 25/100,000, and prevalence has risen from 1.8 to 6.7 per 1000 between 1997-2006, implying that in the UK alone, about half a million people suffer from this condition and 12.000 develop it each year. Recognition of increased PHPT related morbi...

Genetic testing for RET gene was available in the United Kingdom within few years of its discovery, undoubtedly another bonus of universal, nationwide health care system. It was the beginning of Precision Medicine era, which became a watchword for preventative and personalized treatments based on phenotypic, biomarker and genetic characteristics. Surgical Precision on the other hand is an idiom for doing something very well and with meticulous attention to detail. In my presen...

Graves’ disease (GD) is a heterogeneous autoimmune disorder affecting, with varying degrees of severity, the thyroid, eyes and skin. GD is the most common cause of hyperthyroidism. The incidence peaks between 30 and 50 years of age, but people may be affected at any age. Hyperthyroidism is caused by autoantibodies stimulating the TSH receptor on thyroid cells. The severity of thyrotoxicosis in GD is variable and the response to anti-thyroid drugs is difficult to predict. ...

Agranulocytosis is an uncommon but very serious complication during treatment with thyrostatic. In case of severe hyperthyroidism removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option.We present the therapeutic difficulties and successful treatment with preoperative plasmapheresis in 63-year-old female patient with severe hyperthyroidism in the course of toxic nodular goiter and agranulocytosis, which occurred a...

Aim: The aim of the study was to evaluate the birth weight of children born to women with AITD compared to with those born to women without AITD.Material and methods: The study included 596 pregnant women and their children in 2007–2015. The patients were divided into two groups. The first (group A) consisted of 191 pregnant women with chronic autoimmune thyroiditis and their children, while the second (group B) consisted of 405 pregnant women witho...

Introduction: Correlation of papillary thyroid cancer and lymphocytic thyroiditis is well documented but the incidence of thyroid malignancies in Graves’ disease especially in the absence of nodular thyroid disease is considered to be uncommon.Method: We conducted a retrospective audit of forty-four patients with established diagnosis of Grave’s thyrotoxicosis treated with total thyroidectomy from 2010-2013 (36 months), in a tertiary care centr...

Case: A 50-years-old gentleman underwent cardiac surgery which was complicated by postoperative arrythmias and ischemic stroke. He was found to have raised calcium of 2.9 (2.2–2.6 mmol/l) subsequent to which PTH was tested and found to be raised at 34.2 (1.6–6.9 pmol/l) which increased to 41.2 pmol/l in few days. He was referred for work up and management of primary hyperparathyroidism. An USS of the neck showed 1.5 cm nodule posterior to left thyroid lobe and Sestim...