Endocrine Abstracts

Langherhans cell histiocytosis (LCH) and Erdheim-Chester (EC) are two histiocytic disorders which occurrence in the same patient has rarely been described. Thyroid involvement of LCH is rare, and concurrent papillary thyroid carcinoma (PTC) exceptionally reported. We report a case of a 73 year old man who presented a diagnosis of mixed histiocytosis LCH and EC. The patient suffered of insipidus diabetes since 1 year without pituitary abnormality but clinical examination showed...

An 82 year old man was admitted to hospital with lethargy, anorexia and back pain. His past medical history included chronic lymphocytic leukaemia and hypertension. Blood tests revealed a serum sodium of 115 mmol/l and potassium of 5.4. His irbesartan was discontinued and sodium rose to 126 prior to discharge. 9 am cortisol was 408 nmol/l. He was readmitted to hospital 6 days later with hyponatraemia (116 mmol/l). A short Synacthen test was performed which showed a flat respon...

Introduction: Type 1 diabetes mellitus is a T-cell mediated autoimmune disease characterized by the destruction of β-cells of the pancreas. Numerous studies have demonstrated the key role of FoxP3+ regulatory T-cells in the development of type 1 diabetes.Aim: The aim of research: 1) to determine the expression patterns of transcription factor FoxP3 in the pancreatic lymph node cells in animal model of diabetes mellitus and 2) to assay an effect of m...

Objective: To evaluate the alterations of fibrosis biomarkers during empagliflozin treatment in patients with type 2 diabetes mellitus (T2DM) and a very high risk of cardiovascular events.Materials and methods: Twenty-six patients with type 2 diabetes mellitus received 10 mg of empagliflozin within 24 weeks. Inclusion criteria: women and men aged 18 to 70 years with T2DM, glycated hemoglobin (HbA1c) 7.0–11.0%, stable hypoglycemic therapy at least 1...

Recently, sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated cardioprotective effects. However, findings for major adverse CV events (MACE) outcomes with dapagliflozin are not concordant with the empagliflozin studies and the possible mechanisms of cardioprotective effects are not fully understood. The aim of the study was to compare the two distinct SGLT2i, empagliflozin and dapagliflozin, in their influence on the biomarkers of fibrosis and inflammation.</p...

Introduction: Close long-term follow-up of patients with pulmonary carcinoid (PC) tumours is important for detection of recurrence, which can occur many years after primary surgery. Expert consensus guidelines for management of PC were published in 2015 (European Neuroendocrine Tumor Society (ENETS)) and provide recommendations for follow-up type, frequency and duration. The LEAP Project aimed to describe current follow-up practices in the UK following publication of the guida...

Introduction: mTOR is not only a central regulator of lipid metabolism, controlling the processes of adipogenesis and lipolysis, but also a regulator of immunometabolism of immune cells infiltrating the adipose tissue. In its turn, the level of progression of diabetes is largely limited by Treg subpopulation, the complexity and heterogeneity of which is confirmed by the detection of numerous tissue-specific Tregs, including the so-called VAT Tregs (visceral adipose tissue CD4+...

Introduction: Recently, a microduplication of 15q26.3 not including IGF1R was reported in subjects of two families with overgrowth and variable intellectual disability (Leffler M. et al., Eur J Med Gen, 2016).Aim: To report the clinical findings in a third case with overgrowth related to a small microduplication of 15q26.3 not including the IGF1R region.Methods: Comparative genome hybridization was done using an A...

Objective: To study the frequency and features of mental disorders in hospitalized patients, suffering from Cushing’s disease (CD).Materials and methods: We studied 70 patients (59 women and 11 men) with verified diagnosis of CD, aged 41±12 years. Their mental health was evaluated with ICD-10 criteria and verified by the Mini-International Neuropsychiatric Interview questionnaire (MINI 6.0). 45 patients had overt hypercortisolism (untreated CD ...

Purpose: The study evaluated the effects of laser ablation of adrenal glands and results of regeneration using low-vacuum scanning electron microscopy for modeling the effects of laser ablation on pathological focus in the adrenal glands.Methods/design: A study performed on the rats (n=19, male, Wistar line) with weighing 335.3±24.9 g. At 14 of them (control 5 intact rat) under general anaesthetic was performed local laser ablation part of ...