Endocrine Abstracts

Introduction: Although concomitant primary hyperparathyroidism (PHPT) and papillary thyroid carcinoma (PTC) has been repeatedly reported in medical literature with an incidence of 2.3–4.3%, no causal relationship has been elucidated. In most cases, diagnosis of PTC is mostly incidentally, while PHPT is usually the primary pathology. Recent literature supports the possible role of dual-phase 99mTc-MIBI parathyroid imaging in detecting PTC in patients with PHPT.<...

Myasthenia gravis (MG) and autoimmune thyroid diseases (AITD) may coexist and influence one another clinical expression. The opportunity of thymectomy in this association is controversial, since not all the studies have proven its efficacy. We report eight patients (one man and seven women) diagnosed with AITD (Graves’ disease (GD) – five cases, Hashimoto’s thyroiditis (HT) – three cases) and MG. The AITD diagnosis preceded (two cases), followed (three case...

Introduction: Breast cancer is, by far, the most frequent cancer among women. Local and systemic factors have been shown to drive growth in breast cancer cells. There is increasing evidence that hormone ghrelin, known for the growth hormone releasing effect and food intake modulator, may also influence cancer growth. Ghrelin has been shown to be produced by some tumor cells, including breast cancer cells.Objective: To analyze ghrelin expression in correl...

Experimental autoimmune thyroiditis (EAT) has been used to simulate human autoimmune thyroid disease for decades. EAT can be easily induced in genetically susceptible strains of mice by excess iodine ingestion or by immunization with mouse thyroglobulin. Excess iodine may induce and exacerbate autoimmune thyroiditis (AIT) in humans and animal models. In order to assess the potential protective mechanisms of selenium (Se) in thyroid autoimmunity, we evaluated the effects of ino...

Introduction: Ghrelin, a peptide hormone produced in the stomach, stimulates secretion of growth hormone and regulates appetite and energy homeostasis. Various other effects attributed to ghrelin may contribute to many aspects of cancer development and progression.Material and Methods: Using polyclonal antibody immunohistochemistry, we assessed (by intensity scoring) the immunolocalization of ghrelin in 70 tissue samples, and described particularities wi...

Background: Primary hyperparathyroidism (PHPT) associates many psychiatric symptoms and is therefore important to find out if surgery can alleviates the psychiatric symptoms and improve the quality of patient’s life.Objectives: To study the nature and severity of neuropsychiatric manifestations in patients diagnosed with hyperparathyroidism before and after surgery, as well as to evaluate the correlation of such symptoms with levels of serum calcium...

Objective: To determine the impact of combined antidepressant drugs and LT4 enhancers in treatment of patients with Major Depressive Disorder.Method: We conducted a randomized, placebo-controlled trial to determine whether LT4 supplementation had any augmentation effect on selective serotonin reuptake inhibitors (SSRIs). The study involved 70 patients with major depressive disorder; patients with hypothyroidism were excluded. Of the participants, 38 were...

Introduction: The HECa10 line was derived from the specialized endothelial cells typically occurring in lymphoid tissues and belonging to high endothelial vessels (HEVs). Recent studies have shown that HEVs are also present within the tumor microenvironment, what unlike to other blood vessels, can be associated with favorable prognosis of cancer patients. Estradiol (E2) and its metabolite 2-methoxyestradiol (2ME2) are known as the important modulators of cardiovascular system ...

Epidemiological studies underline that obesity represents a significant risk factor for development of several cancer among them colon cancer. Moreover, multiple recent data indicate that some of adipose tissue-derived hormones may influence the growth of malignant cells. Leptin, the product of the ob gene, is one of them. However, research is still contradictory regarding the role of leptin in colon cancer.The aim of our study was to examine the ...

Apoptosis is an important process influencing tissues growth, however the assessment of this process in monolayer culture is difficult because apoptotic cells disappear quickly due to secondary necrosis. Most of the methods used with success in vivo is useless in vitro. Our approach to evaluating apoptosis in vitro is based on the possibility to perform multiple assays on the same sample well. The aim of the study was to evaluate the effect of mifepristone (RU-486), a...