Endocrine Abstracts

Background: Small functional pituitary adenomas can cause severely disabling symptoms and early death, however, surgical planning is often complicated due to inconclusive diagnostic MRI in up to 40% of patients and therefore hamper cure rates. We here introduce a novel method for the detection of small functional pituitary adenoma by O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET) PET-MRI.Methods: Patients with Cushing’s disease (CD) or acromegaly wit...

Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone and very poor prognosis. Standard treatment is docetaxel, followed by androgen-synthesis (abiraterone) or androgen receptor inhibition, or treatment with the novel taxane cabazitaxel. Novel drugs are constantly under development and molecular properties of individual tumors will determine treatment effectiveness in individual cases. The a...

The relation between androgen receptor (AR) gene amplification and other mechanisms behind castration-resistance in prostate cancer, such as increased expression of constitutively active AR variants and steroid-converting enzymes have been poorly examined. Specific aims of this study were to examine AR amplification in treatment-naïve and castration-resistant prostate cancer (CRPC) bone metastases and to explore molecular and functional differences. AR gene amplification ...

Hypothyroidism in pregnancy is generally considered harmful. However, the definition of hypothyroid during pregnancy remains controversial. Measurements of maternal serum TSH have traditionally been used to define hypothyroidism, with values >2.5 mIU/l generally warranting treatment. However, recent data have suggested that the ‘normal’ reference range for serum TSH in healthy pregnant women varies by region as well as by ethnicity. Importantly, changing the uppe...

Background: Over the last decade, bariatric and metabolic surgery has been recognized as an important step in the treatment algorithm for type-2 diabetes (T2DM). Despite early suggestions of surgery providing a potential cure for T2DM, only a small proportion of all patients who could benefit from surgery are ultimately considered for this treatment. Furthermore, the long-term effects on T2DM still remains somewhat controversial.Methods and results: A re...

The spectrum of symptoms associated with hypoparathyroidism span from virtually none to severely debilitating fatigue, memory loss, muscle cramps, and paresthesia. Until recently disease management has focused on securing stable serum calcium values at the lower end of the reference range using potent active vitamin D analogues like Etalpha and Rocaltrol, together with calcium supplementation. Recently maintenance of adequate levels of 25(OH)D have also been mentioned as being...

Over the last 25 years we have been expanding our choice of treatments for os oporosis. The chronic nature of the disease makes long term treatment necessary. It has long been known that long term management of osteoporosis suffers the same compliance problems as chronic treatment regimens for other disease like hypertension, hyperkolesterolemia, etc.The most widely used treatment for osteoporosis is still oral bisphosphonates, which have come under incr...

BackgroundThe 2015 American Thyroid Association (ATA) Risk Stratification System for differentiated thyroid cancer (DTC) is designed to predict response to therapy and recurring disease. Although age is not incorporated as a risk factor, recent research suggests that the addition of age can improve this system. However, these studies comprised low number of patients with ATA High Risk, low numbers of patients with follicular thyroid cancer (FTC), and did...

Background: Since their FDA-approval in 2018, both Lu177-DOTATATE and I131-MIBG radiopharmaceutical therapies are available at our institution for the treatment of pheochromocytoma and paraganglioma (PPGL). Tumor uptake of the radiopharmaceutical on pre-therapy imaging is a requirement for treatment. Here, we describe our experience with pre-therapy imaging, and how it relates to the tumor genotype and the therapeutic choice.Methods: This is a retrospect...

Introduction: The quality of testosterone assays has been a matter of debate for several years. Known limitations of testosterone immunoassays are the cross-reactivity with other steroids and a high variation in the low concentration range. We hypothesized that one of the additional limitations of testosterone immunoassays is an ineffective displacement of testosterone from its binding protein.Methods: Thirty samples from women not using oral contracepti...