Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular (CV) risk markers.Objective: To assess the effects of 6 months treatment with liraglutide 1.8 mg od on obesity, and CV risk markers, particularly platelet function, in young obese women with PCOS compared to matched controls.Design: Interventional case–control study. Carotid intima-media wall thickness (cIMT) was measured by ...

Introduction: Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight.Objective: To assess if PCOS increases CV risk independently in young obese women by examining carotid intima-media wall thickness (cIMT) and platelet function.Design: A cross-sectional study comparing women with PCOS (n=21) ...

The fertility is commonly impaired in acromegalic patients; therefore, pregnancy in acromegaly is relatively a rare event. Little is known about management of pregnant acromegalic patients and the out come of their pregnancies. This is a report of a rather unusual case of a 37-year-old acromegalic lady diagnosed in 2001. Transphenoidal surgery 2002 continued having GH IGF1A so who had two successful pregnancies in spite her active disease. She was diagnosed in 2002 after a cli...

Objective: Phenotypic variability and lack of genotype-phenotype correlations still represent a major challenge in the surveillance of patients carrying germline MEN1 (Multiple Endocrine Neoplasia type 1) mutations. MEN1 associated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly penetrant and show an indolent course. However, they are still the leading cause of death in MEN1 syndrome. Some single-center and national studies reported higher prevalence of GEP-...

Pregnancy is associated with changes in both size and function of the pituitary gland. Thus diagnosing pituitary dysfunction during pregnancy can be challenging. For women with a pre-existing adenoma, there is limited evidence regarding safety in pregnancy for medical therapies used to control hormonal excess. Management includes optimisation of hormonal function and close monitoring for signs of tumour progression. Most women can be managed conservati...

Rates of among women of reproductive age are rising such that 1 in 5 women in the UK are obese at antenatal booking. Female obesity is associated with reduced fertility including ovulatory dysfunction and increased time to pregnancy. Obese pregnancy is associated with increased pregnancy loss and stillbirth, and with increased risk of major pregnancy complications including gestational diabetes and preeclampsia. In addition there are short and long-term complications for the o...

Since completing a PhD in Developmental Neurobiology at King’s College London, I have worked as a Grants Adviser at the Wellcome Trust. Not-for-profit organisations like the Wellcome Trust hold a diverse range of career opportunities for scientists with PhD and post-doctoral experience, from communications to research management. In this short overview talk I’ll give an insight into the role of the Grants Adviser, the opportunities for scientists in the charitable se...

Rates of among women of reproductive age are rising such that 1 in 5 women in the UK are obese at antenatal booking. Female obesity is associated with reduced fertility including ovulatory dysfunction and increased time to pregnancy. Obese pregnancy is associated with increased pregnancy loss and stillbirth, and with increased risk of major pregnancy complications including gestational diabetes and preeclampsia. In addition there are short and long-term complications for the o...

Since completing a PhD in Developmental Neurobiology at King’s College London, I have worked as a Grants Adviser at the Wellcome Trust. Not-for-profit organisations like the Wellcome Trust hold a diverse range of career opportunities for scientists with PhD and post-doctoral experience, from communications to research management. In this short overview talk I’ll give an insight into the role of the Grants Adviser, the opportunities for scientists in the charitable se...

Primary hyperparathyroidism in pregnancy is rare, with a reported incidence of 1%. It is often asymptomatic with the majority of cases in case-series identified incidentally. Published case series report dramatic maternal complications including nephrolithiasis, pancreatitis, hyperemesis gravidarum, pre-eclampsia and hypercalcaemic crises with fetal complications including intrauterine growth restriction, preterm delivery and neonatal hypocalcaemic tetany. Severity of complica...