Endocrine Abstracts

Background: Phaeochromocytomas (PC) are rare tumours of chromaffin cells which may present with relatively common and non-specific symptomatology. The optimal biochemical investigation to confirm or refute the diagnosis remains unclear; some centres use fractionated plasma metanephrines, which are very sensitive but lack specificity, while others use conventional measurements of urinary metanephrines, which may be affected by concurrent drug administration and are less sensiti...

W F Young Jr, Mayo Clinic, Rochester, Minnesota, USA AbstractProf. William Young is Professor of Medicine at the Mayo Clinic College of Medicine and Vice-Chair of the Division of Endocrinology, Diabetes, Metabolism, and Nutrition. He received his MD degree from Michigan State University. Prof. Young trained in endocrinology and metabolism at Mayo Clinic, Rochester, Minnesota. He has been a member of the staff at Mayo ...

Background: The GH-IGF system plays an important role in strength gain. Some studies suggest that Zinc, Magnesium and Pyridoxine (ZMA) supplementation could increase GH/IGF and testosterone levels in young subjects. This hypothetical increase could lead to significant changes in body composition. ZMA is a very popular supplement, easily found in specialty stores, and it is presumed to increase GH, IGF-I and testosterone levels. However, studies are divergent regarding its effi...

Chronic elevation of plasma glucocorticoids adversely affects cognitive processes and the structural and functional integrity of the hippocampus. Crucially, inter-individual differences in memory with ageing directly associate with blood glucocorticoid levels in rodents and humans; indeed higher plasma corticosterone in mid-life in rodents predict subsequent memory impairments. However, although keeping glucocorticoid levels low by adrenalectomy in adult life prevents the emer...

Background: Many young people have inadequate follow up because they lose contact with adult care following transfer from paediatrics. There is a need to adapt communication interventions to help young people to determine and enact their preferred involvement in consultations with health professionals.Objective: To develop interventions to support communication with young people in endocrine care and to assess the feasibility of implementation in routine...

Introduction: Although menstrual irregularity, including oligomenorrhea (OM), is associated with insulin resistance and hyperandrogenism, the relationship between the severity of menstrual infrequency and clinical phenotypes in young women with OM is unclear. We evaluated whether a longer menstrual cycle length is associated with less favorable metabolic features in young women.Methods/design: A total of 1296 young women (aged 15–39 years old) with ...

Objective: Having a psychiatric disorder may increase the risk of developing type 2 diabetes (T2D) and we aimed to determine whether young adults with a psychiatric disorder have an increased risk of developing T2D.Research Design and Methods: We conducted a nationwide cohort study to evaluate the association of different psychiatric disorders with the risk of T2D in the young population. Records of 6.457.991 adults aged 20−39 years without a histo...

Numerous epidemiological studies worldwide have shown a strong association between low birth weight and an increased risk of developing cardiometabolic disease, including hypertension. Excessive fetal exposure to glucocorticoids has been hypothesised to mediate this relationship. Here, we have used an established rodent model – in which dexamethasone, a synthetic glucocorticoid that readily crosses the placenta, is administered to pregnant Wistar rats during the last trim...

Risk factors were assessed, including lipid spectrum studies, among young patients. The survey included 225 men and 327 women. All examined patients had no clinical signs of diseases of the cardiovascular system and type 2 diabetes mellitus. The median age was 33.35 (31.15; 35.52) years. Obesity was 1.6 times more common among young men than among women (χ2 = 4.67; P = 0.03). The relative risk of developing (RR) obesity in (men/women) was 1.79 (1.23 ÷ 2.60); P</e...

Fragility fractures in the young individual are an uncommon clinical scenario and when faced with such a situation, appropriate assessment is required to ensure correct diagnosis of the underlying aetiology and to avoid unnecessary interventions. Although, primary causes of osteoporosis such as osteogenesis imperfecta are considered rare, this group of conditions has considerable phenotypic and genotypic heterogeneity and may be underdiagnosed. However, the majority of the you...