Endocrine Abstracts

Background: Obesity is associated with complex multisystem pathology and significant psychosocial burden. Yet, despite its increasing prevalence, the commissioning of Specialist Weight Management Services remains limited.Methods: Retrospective service evaluation of a proportion of patients (n=179) engaging with the Central London Community Healthcare Specialist Weight Management Service for at least 6-months from 2012 onwards. Outcome measures, ...

Introduction: Wilson’s disease is a rare and serious genetic disorder. The accumulation of copper in glands causes several endocrine pathologies. Herein, we report a rare case of hypophysitis with corticotropic deficiency caused by Wilson’s disease.Observation: A 33-years-old female patient was referred to the endocrinology department for hypoglycemia. She had a history of Wilson’s disease diagnosed at the age of nine complicated by cirrho...

Background: Skeletal changes including demineralization have been reported in WD. The exact mechanism originating these changes isn’t completely understood but some authors have proposed a link to vitamin D (VitD) metabolism.Aim: To investigate the prevalence of demineralization in a cohort of WD patients and correlate it with VitD status and severity of hepatic and neurological involvement.Methods: Thirty-five patients (17 ma...

Osteoclasts are long lived highly specialised bone resorbing cells which form through the fusion of mononuclear pre-cursor cells and are believed to follow a linear fate and undergo apoptosis at the end of their life cycle. A number of anti-resorptive therapeutics target these cells, either preventing their resorptive function, Bisphosphonates, or inhibiting their formation, Denosumab (Anti-RANKL-Dmab). These agents have achieved success i...

Aims: Exercise increases beta cell health in people at risk of, and with established type 2 diabetes (T2D). These benefits of exercise have not been characterised in T1D. Over 10% of beta cells are still present at the time of diagnosis with T1D, and exercise has the potential to preserve them. We aimed to explore the mechanisms through which exercise could improve beta cell health in T1D by investigating the effects of exercise serum on apoptosis and proliferation of the MIN6...

Episodes of in-hospital hypoglycaemia are uncommon but serious events, which cost the NHS financially and cost the patient in terms of poor clinical outcomes, and rarely, mortality. The National Patient Safety Agency reported that in 2007, one in four adult diabetics experienced an episode of hypoglycaemia whilst in hospital. Moreover, one in 30 required i.v. glucose or i.m. glucagon therapy, and between 2003 and 2009 there were four deaths involving insulin overdose2</su...

Background and Aims: As a loss of functional β-cell mass contributes to type 2 diabetes (T2D), increasing β-cell proliferation is a potential therapy to compensate for impaired insulin output. Long non-coding RNAs (lncRNAs) regulate several key β-cell genes and the presence of more than 1100 human β-cell enriched lncRNAs raises the potential for wider roles. Here we have identified 5 independent studies that capture the β-cell transcriptome during adap...

Introduction: Obesity is an independent risk factor of coronary artery disease, and it has also been shown to be associated with increased survival in some instances such as myocardial infarction – dubbed the ‘Obesity Paradox’. However, there is a paucity of studies identifying the type of myocardial infarction – non-ST-segment elevation MI (NSTEMI) or ST-segment MI (STEMI) – that may be differentially prevalant according to BMI (body mass index) ...

In Northern Ireland the annual marching season starts around April/May and can last until the end of September. This is a time when those children and young people with Type 1 Diabetes Mellitus who are involved in parades, need advice from the diabetes team regarding the variations in their activity levels. This can be a very delicate subject within the cultural setting, revealing their allegiance for one side of the community or the other and can be very sensitive. As a resul...

MLE4901 (previously AZD4901) is a potent and selective neurokinin 3 receptor (NK3R) antagonist being developed for the treatment of polycystic ovary syndrome (PCOS). Clinical studies indicate the compound negatively regulates the hypothalamus-pituitary-gonadotropin (HPG) axis to reduce pituitary luteinizing hormone and gonadal sex steroids. To understand the longer-term in vivo effects of MLE4901, a 13-week safety study was carried out. Groups of 3 male and female dog...