Endocrine Abstracts

Background: Increased childhood cancer survival has resulted in an accruing adult cohort faced with potential infertility. Pre-treatment semen cryopreservation can protect reproductive capacity in adolescent minors, but continued unique legal, ethical and educational barriers prevent consistent service provision across the UK. The effect of pubertal maturation, disease and treatment on the ability to produce sperm also remains poorly defined in this cohort. We present our 10-y...

IntroductionVarious direct and indirect mechanisms by which glucocorticoid (GC) excess and elevated adrenocorticotropic hormone (ACTH) levels impairs bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with CD including preoperative ACTH levels and the clinical severity of the disease. Combining these data, we conducted a retrospective study to inves...

Premature ovarian failure (POF) is defined as cessation of menstruation before the expected age of menopause. The disorder is considerable heterogeneous with a wide spectrum of causes- genetic, autoimmune, metabolic, infectious, and iatrogenic. However, etiology remains to be elucidated in most cases.Chromosomal abnormalities have long been recognized as frequent causes of POF. However, few large cohorts have been studied. Ethnic background is usually no...

The pituitary gland is altered by both anatomical and physiological changes during pregnancy. The most striking finding is the physiological enlargement of the pituitary gland as a result of lactotroph hyperplasia. Hormonal evaluation of pregnant women requires special consideration due to the emergence of the placenta as a new source of hormone production, changes in binding globulin levels and resistance to hormones such as glucocorticoids.Pituitary ad...

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The management of type 1 diabetes (T1D) in puberty and adolescence is characterized by special challenges related to the dramatic hormonal, emotional and social changes in the teenage years. It is a period of transition from physical immaturity to maturity and from parental dependency to independence. The daily application of insulin, necessity of frequent selfmonitoring of blood glucose and awareness of diabetic diet represent additional burdens for teenagers with diabetes. I...

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Introduction: Poor linear growth in CP associated with osteopenia, increased fracture risk, and decreased muscle mass attributed to nutritional factors as well as non-nutritional factors such as those involving the neurologic or endocrine systems has been well described in literature.Objective: This study assessed the growth of children with CP and other motor disorders attending a Children’s Development Centre for treatment, fed only orally.<p ...

Prostate cancer cells show a variable expression of androgen receptor (AR). Its function is influenced by coregulatory proteins that may interact with the N-terminal and/or ligand-binding domain. Cofactor expression and function may be altered in prostate cancer. Studies by my group were focused on the transcriptional integrator CBP and its functional homologue p300 in prostate cancer. We found that CBP selectively potentiates activation of the AR by the non-steroidal anti-and...

Introduction: The inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse is a distressing and common symptom in Bangladeshi Diabetic subjects.Aims and Objectives: The purpose of this study is to present a framework for cost effective evaluation & treatment. Because many of the diabetic subjects usually suffers from psychological stress since he is detected as diabetic and many of them believe in Myths that diabet...