Endocrine Abstracts

Cigarette smoking is the major cause of disease related deaths in the world. Cigarette smoke contains many harmful chemicals, among them nicotine is the most potent one. The root cause of smoking hazards is nicotine addiction or dependence (ND). Environmental as well as genetic factors are reported to influence smoking which leads to nicotine addiction in all age groups especially. Neurexin1 is a cell adhesion protein important for synapse formation and CHRNB4 is chol...

As a lingering, often deteriorating brain disease, addiction causes neurotic drug seeking and utilization along with injurious significances to the addicts and to those living around them. Biological, genetic and a number of intrinsic and extrinsic environmental constituents are most vital in entire risk factors of drug addiction. Among addictive drugs opioid dependence is considered as the most deliberated drug abuse disorder and a major social dilemma worldwide. Opioids indu...

Background: Hypercalcemia in patients with advanced chronic liver disease (CLD) without hepatic neoplasia is a rarely reported and poorly understood entity. CLD is usually associated with hypocalcaemia because of hypoalbuminemia. Hypercalcemia on the other hand is extremely rare and needs meticulous ruling out of other causes.Case Report: A 55-year-old male who was admitted with jaundice, weight loss and hypercalcaemia. He had a calcium that peaked at 3....

Section 1: Case history: A 78 years old lady presented to Emergency Department with two weeks history of lethargy and confusion. She had background of advanced destructive Rheumatoid Arthritis diagnosed 30 years ago, multiple joint fractures, osteoporosis, long-term urinary catheter, recurrent UTI and renal calculi. She was recently discharged from hospital for urosepsis. She was bed-bound for the last 15 years after crushing vertebrae C2 C3 pressing on spinal cord. Her regula...

Background: Primary Hyperparathyroidism is a leading cause of hypercalcaemia and is frequently asymptomatic. Due to its long-term complications, early diagnosis and management is essential. NICE published guidelines on diagnosis and management of Primary Hyperparathyroidism in May 2019. The aim of this audit was to compare our existing practices against NICE guidance.Methods: We conducted retrospective data collection by identifying patients diagnosed wi...

Introduction: Primary hyperparathyroidism is associated with numerous cardiovascular complications including hypertension, left ventricular hypertrophy and calcification of cardiac valves. However, guidelines from expert panels and NICE have not included cardiovascular complications as an indication of parathyroidectomy. This literature review will be focused on benefits of parathyroidectomy on cardiovascular complications of primary hyperparathyroidism....

Background: Cushing’s syndrome (10-15/million people diagnosed/year) is quite rare with Cushing’s disease accounting for >70% of cases in adults. Spinal epidural lipomatosis (SEl) secondary to endogenous Cushing’s syndrome is even more rare condition (8 reported cases so far) of which 3 cases are secondary to Cushing’s disease. Here, we highlight a case of ACTH-dependent Cushing disease with resultant spinal epidural lipomatosis (SEl) that was treated w...

Introduction: Adrenal insufficiency is a common problem in our country due to steroid abuse in various forms. In many occasions the patients even do not know about its side effects and consequences of non-prescribed usage. Many of them presents with sudden withdrawal and adrenal crisis. Many of them admits in Gastroenterology unit due to vomiting, some of them in Medical unit with unexplained fever, weakness, anaemia, etc. Many of them having subtle features of Iatrogenic Cush...

Introduction: Prevalence of prolactinoma is approximately 10/100,000 (men) and 30/100,000 (women) and dopamine agonists remain pharmacological treatment of choice. Cabergoline, an effective dopamine agonist, is preferred due to better tolerability withhigher efficacy in lowering prolactin and reducing tumour size in comparison with bromocriptine. Digital vasospasm, known adverse effect of Bromocriptineis mediated by activation of α1 adrenergic receptors. ...

With over 500,000 fragility fractures a year and an ageing demographic, tackling the burden of osteoporosis is an urgent national priority. Effective secondary fracture prevention within the NHS could prevent over 20,000 fragility fractures including 9,000 hip fractures within 5 years. Ensuring this care gap is closed requires support from political prioritisation, business case models, getting started and getting improved and sustainable. This presentation will highlight the ...