Endocrine Abstracts

Introduction: Egypt has an epidemic of HCV. Interferon (IFN) is the drug of choice for treatment induces autoimmune thyroiditis. The biochemical characteristic of the autoimmune thyroid disorder is the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Chemokine ligand 10 (CXCL10) is an IFN inducible chemokine involved in the autoimmune thyroid disease.Aim: To assess the incidence of autoimmune thyroid disorder following treatment w...

Background: It was noted in the last few years there was an increased incidence of vasculitis and vasculitic reactions in patients with thyrotoxicosis. Those vasculitic reactions ranged from simple purpuric skin lesion to sever intra-alveolar hemorrhage and even to Steven Johnson Syndrome, Most of those vasculitic reactions occurred in patients receiving propylthiouracil or methimazole. But many other cases were detected in thyrotoxic patients even be...

A 25-year lady was referred to GSTT for further management of thyrotoxicosis as she had relocated to London. The patient developed thyrotoxicosis during her pregnancy at the age of 23. During her pregnancy, she had significant weight loss. Her thyroid function test in September 2020 showed TSH 0.04 mU/lwith FT4 of 24.1 pmo/land TSH receptor antibody of 1.35 U/l. Hence she was started on propylthiouracil (PTU) during pregnancy. PTU was titrated down based on biochemical respons...

A 40-year-old female was referred for further management of thyrotoxicosis to GSTT. She worked as a nanny and had Graves’ thyrotoxicosis since October 2019. Her presenting symptoms were weight gain, hair loss, insomnia, and increasing anxiety. She had a large palpable goitre on examination with no eye disease. Ultrasound of the thyroid showed a diffusely enlarged thyroid with a normal echotexture, reflectivity and vascular flow. Benign subcentimeter nodules were seen in e...

A 75-year-old lady was referred to our centre from a local DGH, where she presented with constipation, reduced consciousness and acute confusion. She was found to have severe hypercalcaemia (Adjusted Calcium 5.21mmol/l), with PTH of 1473ng/l, and urine calcium of 13.8mg/24 h. Based on available biochemistry, a presumptive diagnosis of Parathyroid Carcinoma was made, and Hypercalcemia management was started. She was given about 3 litres of fluid and 60mg of pamidronate. Subsequ...

Introduction: Dysgonosomies are abnormalities of the number of gonosomes X and Y. They have fewer Phenotypic repercussions than the aneuploidies involving autosomes, and are mostly viable. The 47 XYY are generally boys with normal phenotype. The prevalence is around 1 per 1000 birth boy but undoubtedly under diagnosed given the often normal phenotype associated with this chromosomal formula, in addition to the lack of large-scale studies. There is no gonadal dysgenesis and oft...

DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 [1-3] as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome, usually presents later in childhood, often leading to hypernasal speech caused by cleft palate, submucous cleft palate, or velopharyngeal insufficiency. Both disorders share similar clinical feature...

Introduction: DiGeorge syndrome is a genetic abnormality caused by a microdeletion of chromosome 22. Chromosome 22q1 1.2 microdeletion was first identified in 1992 as the common genetic anomaly associated with a range of conditions previously known as DiGeorge or velocardiofacial syndrome.Case report: A 17-year-old Moroccan male was mildly mentally challenged and had seizures from the age of 9 years. He had dysmorphic facial features, and mild tortuosity...

Introduction: Glargine is a recombinant human insulin analogue, used in the treatment of diabetes mellitus. Although widely used, information regarding the altered time-effect profile of glargine taken in overdose is scarce. We describe a case which highlights this phenomenon.Case report: An 82-year-old female was found by her neighbour, 18 h after attempting suicide by injecting herself with 600 units of glargine at multiple sites. Her capillary blood g...

Introduction: Ectopic thyroid tissue can be found anywhere along the normal path of thyroid descent, but is most commonly found at the base of the tongue, in which case it may be referred to as a lingual thyroid. Although the patients are usually asymptomatic, it can lead to symptoms such as dysphonia and dysphagia. We present a child patient with a lingual thyroid resulting in severe dysphagia that was cured surgically.Case reports: An 4-year-old male c...