Endocrine Abstracts

Objetives: To analyze the profile of patients referred from Primary Care (PC) to Outpatient Diabetes Center (ODC), as well as the evolution of self-assessment measured by Chronic Care Model IEMAC (Instrument for the Evaluation of Attention Chronicity Models) tool after implementation of a coordinated Task Force between Primary Care and Endocrinology Unit.Methods: The working group of the Advanced Diabetes Center in Cádiz-San Fernando Sanitary Area w...

Introduction: Fine needle aspiration biopsy (FNAB) is the mainstay diagnostic procedure for evaluation of thyroid nodules, but it doesn’t permit to distinguish between benign and malignant follicular lesions (category IV in the Bethesda Cytopathology System). Some reports have suggested an association between increased serum levels of TSH and thyroid cancer. However, the specific relationship between TSH and malignancy has been scarcely studied in follicu...

Our objective was to estimate the distribution of Spanish diabetic patients attending to individualized glycaemic targets recommended by the ADA/EASD consensus with and without considering hypoglycaemia risk. We conducted a cross-sectional study in a Spanish primary care setting between 2011 and 2012. A total of 5382 type 2 diabetic subjects under antihyperglycaemic treatment for at least 3 months prior to inclusion completed a study visit in which clinical data including age,...

Objectives: Obesity and type 2 diabetes mellitus (DM2) are risk factors for non-alcoholic fatty liver disease (NAFLD). The main objective was to study the incidence of NAFLD using the Hepatic Steatosis Index (HSI) in obese patients with DM2. Secondary objectives were to analyse the effect of liraglutide over HSI, body mass index (BMI) and glycated hemoglobin (HbA1c).Methods: Retrospective observational study of obese type 2 diabetic patients treated with...

Objective: To determine the prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism and their relationships with metabolic syndrome (MS) parameters in female-to-male transsexuals (FMT).Design and methods: Seventy-seven FMT were assessed clinically and biochemically to hyperandrogenism, before the beginning of the treatment with testosterone. We also assessed cardiovascular risk factors and other parameters of MS.Results...

Background: Endothelial dysfunction may have deleterious effect cardiovascular pathology in diabetic patients.Atrial natriuretic peptide (ANP) exerts beneficial effects on the cardiovascular system in part by exerting antioxidant activity. Recently it was reported that ANP is able to exert an antihypertrophic effect in myocitos at least in part due to inhibition of NADPH oxidase and superoxido generation.It seems that hyperglucemia...

Temozolomide, an alkylating agent used in malignant gliomas, has been recently used too in the treatment of aggressive pituitary tumors. To date, two cases of Nelson’s syndrome has successfully treated with 5 days of 28-day cycle, but the follow-up has been shorter than 12 months. We reported the third patient with Nelson’s syndrome treated with temozolomide, who after an initial goal response to three 300 mg 5 days of 28-day cycles shown a clinical and biochemical (...

Prevalence of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS) in female to male transsexuals (FMT) is controversial. To known the prevalence of hyperandrogenism and PCOS in FMT, and their relation with insulin resistance (IR) and other cardiovascular risk factors (CVRF), we studied 77 Spanish consecutive FMT cases, the first ones who appeared in our Gender Unit between May 2007 and Dec 2008, aged 18–43 years. The subjects had never received hormonal treatment o...

Aim: To assess ET1 levels in diabetic patients with and without microangiopathy, and compared with normal subjects, nondiabetic, without underlying vascular pathology.Introduction: The pathophysiology of diabetic microangiopathy is complex and many important aspects of it still are not fully understood. Endothelial dysfunction is of major importance in the pathogenesis of atherosclerosis and diabetic angiopathy. ET-1 is one of the most potent vasoconstri...

Moderately elevated body iron stores may be associated with several components of the metabolic syndrome (MetSyn). Elevated serum ferritin levels (Fer) independently predicted incident type 2 diabetes in prospective studies in apparently healthy men and women.Aims: To analyze the association between Fer and components of MetSyn in transsexuals before and after 2-year cross-sex treatment (CST).Methods: Before starting the CST in 90 ...