Endocrine Abstracts

Background: By regulating the concentration of active estrogens in tumor cells, steroid hormone-inactivating estrogen sulfotransferase (SULT1E1) and estrogen activating steroid sulfatase (STS) may influence the progression of EOC. Therefore, we determined the expression and prognostic impact of both enzymes together with the ERα/β and the progesterone receptor (PGR) in this tumor entity.Methods: The mRNA expression levels of STS, SULT1E1, ER&#9...

The 19th century saw the emergence of an extraordinarily gifted group of Dublin doctors who enjoy eponymous recognition. Immediately on graduating Robert Graves’ travelled for over 2 years to many of the foremost medical centres in Europe. On his return he introduced formal bedside teaching and daily lectures which has become the model for clinical training in these islands. Graves’ main other interest was the treatment of febrile illness recognizing the importance o...

The 19th century saw the emergence of an extraordinarily gifted group of Dublin doctors who enjoy eponymous recognition. Immediately on graduating Robert Graves’ travelled for over 2 years to many of the foremost medical centres in Europe. On his return he introduced formal bedside teaching and daily lectures which has become the model for clinical training in these islands. Graves’ main other interest was the treatment of febrile illness recognizing the importance o...

Robert McLachlanProfessor Robert McLachlan, FRACP, PhD is a Principal Research Fellow of the Australian NH&MRC and Director of Clinical Research at Prince Henry’s Institute of Medical Research in Melbourne, Australia. His interests include male reproductive endocrinology and the evaluation and management of male infertility, and androgen physiology. He is Deputy Director of Endocrinolog...

Robert Semple is a Reader in Endocrinology and Metabolism and Honorary Consultant Endocrinologist at the University of Cambridge, UK. He read Biochemistry and then Medicine at the University of Cambridge before internal medical posts in London. He returned to Cambridge for specialist training in Diabetes and Endocrinology, interrupted by doctoral studies with Prof. Sir Stephen O’Rahilly, focussing on transcriptio...

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of the knowledge in the field of endocrinology through publication. Further information on the prize can be found at http://www.ese-hormones.org/prizes/eje.aspx. This year’s recipient is Dr Robert Semple. The prize will be presented as part of the ECE 2015 opening ceremony where Dr Sem...

The hypothalamus integrates the neuroendocrine control of numerous hormonal systems. Energy balance is regulated by a complex neuroendocrine feedback loop, in which the ventromedial hypothalamus (VMH) responds peripheral neural and hormonal afferent signals of satiety and energy reserve (through insulin and leptin), interprets these as anorexigenic (a-MSH) or orexigenic (NPY, AgRP) signals (through the melanocortin-4 receptor), and then directs efferent autonomic signals (symp...

Our understanding of endocrine adaptation to exercise is underpinned by studies which demonstrated a causative link between low energy availability, hypothalamic-pituitary-adrenal (HPA) axis activation and hypothalamic-pituitary-gonadal (HPG) axis suppression. These and myriad other effects have been observed in elite athletes, termed Relative Energy Deficiency in Sport (RED-S), whereby negative hormonal and metabolic ramifications of exercise can be mitigated by increasing th...

The adverse effect of childhood cancer and treatment thereof on growth was firmly established in the mid-1970’s. The impact on growth is multifactorial, however, cranial irradiation was quickly established as one of the most important contributors. Exposure of the hypothalamo-pituitary (HP) region to radiation in childhood cancer survivors is now a well-established risk factor for the development of anterior hypopituitarism. The degree of hypopituitarism can vary between ...

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