Endocrine Abstracts

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by the presence of hepatic steatosis, which can progress to non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. There are no licensed therapies to halt MAFLD progression, despite it is becoming the most important etiology for advanced liver disease.Aim: The aim of the study was to evaluate the therapeutic potential of inorganic nanopartic...

Introduction: Cushing’s syndrome (CS) secondary to ectopic adrenocorticotrophic hormone (ACTH)–producing prostate cancer is rare with less than 30 cases reported. We report a case of Cushing’s syndrome secondary to prostate adenocarcinoma with recurrent hypokalemia, sepsis and rapid disease progression. A 61-year-old man presented in January 2019 with 3-week history of lower limb swelling and weakness. Past medical history is significant for metastatic prosta...

Background: Elevated reverse triiodothyronine (rT3) is a characteristic feature of euthyroid sick syndrome (ESS), which is associated with mortality in critical patients. However, the lack of reference values limits the use of rT3 for ESS diagnosis and the prognostic value of rT3 is unclear. This study aimed to determine the reference range of rT3 in the ESS identification and mortality prediction in critically ill patients.Methods: This ongoing prospect...

Background: Handgrip strength (HGS) and skeletal muscle mass (SMM) are associated with all-cause and cardiovascular disease (CVD)-specific mortality risk in type 2 diabetes (T2DM) patients. However, the pattern of this association was unclear. We aimed to explore the pattern of associations between HGS and SMM with all-cause and CVD mortality risk in a diabetic population.Method: Data were obtained from the UK Biobank (application number 92014), a large ...

Background: Psoriasis is associated with a heightened prevalence of cardiovascular risk factors, including diabetes. However, it is not clear whether diabetes will cause differences on clinical outcomes of psoriatic patients who have already suffered from coronary artery disease.Methods: We conducted a retrospective cohort study of consecutive psoriatic patients with coronary artery disease between January 2017 and May 2022 in our hospital. The clinical ...

Background: Psoriasis is associated with a heightened prevalence of cardiovascular risk factors, including metabolic syndrome (MetS). As so far, it is not clear whether MetS will cause differences on clinical outcomes of psoriatic patients who have already suffered from coronary artery disease.Methods: We conducted a retrospective cohort study to determine the effects of MetS in psoriatic patients with coronary artery disease. Comparisons were made betwe...

Background: Diabetes prevalence and mortality are increasing rapidly and glycemic goals (hemoglobin A1c < 7%) are often not achieved in patients with type 2 diabetes in China, The low control rate of diabetes has become a global problem. The management of community diabetes is the most effective choice to prevent and control chronic diseases.Objective: To improve the management of diabetes mellitus in community, we analyze the effect of hospital-comm...

Objective: Aldosterone production can be regulated by adrenocorticotrophic hormone (ACTH) which normally controls cortisol secretion. Some cases of aldosterone-producing adenoma (APA) display features which may suggest increased sensitivity to the stimulatory effects of ACTH. The aim of this study was to investigate if there is any relationship between the hypothalamic--pituitary-adrenocortical (HPA) axis activity and the characteristics of APAs.Methods:...

Teriparatide (TPTD) reduces the vertebral and nonvertebral fracture risk. TPTD increases bone formation and improves the cancellous bone microstructure which is an important determinant of the mechanical integrity of vertebrae. The aim of our study was to evaluate first time the effect of TPTD on cortical microstructure and dynamic histomorphometric indices in patients with osteoporosis with or without prior therapy with ALN. Sixty-six postmenopausal women with osteoporosis, m...

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