Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, most cases with parathyroid adenoma as the underlying pathology. However, when blood and urine calcium levels and PTH are higher than normal in PHPT, t’s important to suspect an ectopic PTH secretion or a parathyroid carcinoma. Intrathyroidal parathyroid cysts are extremely rare cause of severe PHPT.Clinical case: A 36-year-old male presented with dizziness ...

Case history: A 30 years old male Caucasian had his saliva tested on a self-funded commercial DNA testing to identify his ancestral roots. The markers for Y chromosome were found to be absent and further evaluation revealed him to have 46 XX karyotype.This was consistent with the diagnosis of De la Chapelle syndrome or XX male syndrome. Fluorescence in situ hybridization (FISH) studies confirmed the presence of SRY (sex determining region Y) gene which was responsible...

Objectives: To determine the association between adverse pregnancy outcomes with each of the 75 g OGTT cut-off values prescribed by the World Health Organization (WHO), Philippine Obstetrical and Gynecological Society (POGS), and the International Association of Diabetes in Pregnancy Study group (IASDPG) criteria to help define more appropriate glycemic cut-off levels for Filipinas.Methodology: Retrospective Cohort study of pregnancy deliveries in De La ...

A 36-year-old woman in follow-up due to early ovarian failure of idiopathic origin. No family history of interest. History of menarche at 12 years of age with regular menses until 18 years of age, when it begins with amenorrheic spells lasting up to 8 months. Laboratory tests revealed hypergonadotropic hypogonadism with negative ovarian autoantibodies, normal karyotype, and gynecological ultrasound showing a normal-looking uterus with slight bilateral ovarian atrophy. Negative...

Introduction: Hyponatremia(HN) is frequent in the emergency room(ER), yet often ignored, or poorly studied/managed. Our objective was to determine the characteristics of patients presenting HN at the ER of a general hospital.Methods: Retrospective analysis of all 347 patients(AllP) presenting/developing non-translocational HN (serum sodium (SNa)<135 mmol/l) the first 48 h at the Hospital Clinico San Carlos ER in August 2012. Volemia was determined by...

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...

Introduction: Fatal insomnia is a neurodegenerative spongiform prion disease. Presentation can be sporadic or hereditary (autonomal dominant). The latter, FFI, is caused by a mutation in the human prion protein gene on chromosome 20. Affected individuals present a disorderd sleep-wake cycle, dysautonomia and motor signs, with a predominance of lesions in the thalamus. SIADH has been described in two affected patients.Case Study: A 70-year-old woman was r...

Background: Identifying the etiology of hypoglycemia in a non-diabetic patient is a significant challenge. Hyperinsulinemic hypoglycemia can lead to pancreatectomy in patients with no evident organic disease. Insulin autoimmune syndrome (IAS) or Hirata diseaseand Type B insulin resistance syndrome are the two typesof autoimmune hypoglycemia, with a low worldwide prevalence.Objective: We report two real-lifecases that illustrate each of them.<p class=...

ContextThyroiditis is defined as an inflammation of the thyroid gland. There are several kinds of thyroiditis, and they can be associated with either increased, decreased, or normal thyroid function (triphasic-course). Subacute granulomatous thyroiditis, also known as subacute thyroiditis (SAT), giant-cell thyroiditis, or de Quervain thyroiditis, is a self-limited thyroiditis characterized by neck pain and thyroid dysfunction. Generally, it is preceded b...

Introduction: Non-alcoholic fatty liver disease (NAFLD) is an emerging disease in Mexico and it could become in a public health problem, this one understands a spectrum of histopathological findings ranging from simple steatosis to steatohepatitis and cirrhosis. The gold standard continues to be the liver biopsy, but several mathematical indexes have been proposed, such as non-invasive techniques, however there are very few studies in our population. This study aims to compare...