Endocrine Abstracts

Introduction: SOX2 is an early developmental transcription factor and a marker for pituitary progenitor cells.The study aimed to investigate if the pituitary adenomas with positive SOX2 immunoreactivity shows a different response to therapy as compared with controls.Patients and methods: We investigated 15 pituitary macroadenomas, eight with SOX2 immunoreactivity (SOX2+) and seven without (SOX2−) (controls); five were GH prod...

Introduction: Pituitary adenomas (PA) represent approximately 15% of all intracranial neoplasms, with a global incidence of 15,20 per million per year. The immunohistochemical analysis of PA is necessary for diagnosis and plays an important role in the modern classification system of pituitary tumors.Material and methods: Samples from 142 surgically resected PA were studied immunohistochemically using antisera for 6 anterior pituitary hormones. Reticulin...

Introduction: Endogenous Cushing syndrome (CS), is associated with significant morbidity (metabolic, cardiovascular, bone, psychiatric complications among others). Most complications tend to improve if hypercortisolism is controlled but some are only partially reversible or even experience temporary exacerbation.Patients and Methods: We report 2 cases of adrenal Cushing Syndrome (CS). The first is a 72 years-old female with CS caused by bilateral macrono...

Introduction: Acromegaly is a rare disease usually caused by growth hormone (GH) secreting pituitary adenomas (PA) and associated with a series of complications, including tumours. The most prevalent tumour types are colonic adenomas, colorectal cancer (1) and nodular goiter (2). We present two acromegaly cases attending our center that associate cervical cancer and another that associates melanoma. Clinical cases: Case 1: A 56-yea...

Introduction: Primary hyperparathyroidism (PHPT) is associated with adverse effects especially on the bones and kidney. While nowadays it is mostly diagnosed at an asymptomatic stage, patients with overt involvement of the target organs at the time of diagnosis are still encountered.Aim: To explore the frequency of disease complications already present at the time of diagnosis in a cohort of patients with sporadic PHPT who meet the current surgical guide...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the postsurgical evolution of craniopharyngioma in adults after total or incomplete surgical resection.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Buc...

Introduction: Riedl thyroiditis is a rare thyroid disorder of unknown etiology (autoimmune assumed), in which the gland is invaded by dense fibrous tissue, that extends in the vicinity. Goiter is usually painless and can be accompanied by other fibrous affections (retroperitoneal fibrosis, sclerosing cholangitis, mediastinal fibrosis).Case presentation: Patient, 39 years old, smoker, from nonendemic area, initially presents in 2011 with voluminous polyno...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the posttreatment evolution of craniopharyngioma in children and adults in a large mixed cohort.Material and Methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest ...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the potential differences in the clinical and radiological presentation of craniopharyngioma in children versus adults in a large mixed cohort.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the Na...

Introduction: Endogenous Cushing’s syndrome (CS) is a rare disease associated with severe morbidity and increased mortality if untreated. Glucose metabolism is significantly altered in hypercortisolism.Objective: To retrospectively analyse the clinical presentation of a cohort of patients with endogenous CS and study the frequency of glucose metabolism abnormalities as opposed to other clinical signs and symptoms.Material and ...