Endocrine Abstracts

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder amongst women of reproductive age and is associated with various cardiometabolic perturbations, in addition to chronic anovulation and factors related to androgen excess. Indeed androgen excess has been associated with increased cardiovascular risk in women; serum testosterone correlates with indices of subclinical atherosclerosis and cardiovascular disease (CVD). Moreover, women with PCOS, as compared with...

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of young women and depending on the diagnostic criteria, it affects 6% to 20% of reproductive aged women. PCOS is also the most common cause of hyperandrogenism in young women with the theca cells of the ovary being the source of androgen excess. PCOS is rarely associated with severe hyperandrogenaemia and atypical features such as rapid progression, presence of virilization or very high Testo...

Orexins, acting via their receptors, are involved in the control of feeding, sleep-wakefulness, arousal, neuroendocrine homeostasis and autonomic regulation. However, the 5′ structure and regulation of human orexin type 2 receptor (OX2R) gene remains is not known. We present original findings regarding the 5′ structural organization of the human OX2R gene and identify four OX2R mRNA transcripts that differ in their 5′-untranslated region (UTR). The four trans...

Orexins, acting via their receptors, are involved in the control of feeding, sleep-wakefulness, arousal, neuroendocrine homeostasis and autonomic regulation. However, the 5′ structure and regulation of human orexin type 2 receptor (OX2R) gene remains is not known. We present original findings regarding the 5′ structural organization of the human OX2R gene and identify four OX2R mRNA transcripts that differ in their 5′-untranslated region (UTR). The four trans...

Introduction: Women with polycystic ovary syndrome (PCOS) have a clustering of cardiovascular risk factors, such as obesity, lipid abnormalities, impaired glucose tolerance, insulin resistance and hypertension. Exercise is reported to lower cardiovascular morbidity and mortality and improve reproductive health. The effect of exercise on plasma adiponectin and the components of leptin system, namely plasma free (FL) and bound (BL) leptin concentrations, have not been previously...

Introduction: Asprosin is a novel adipokine that is released in response to fasting and can elicit orexigenic and glucogenic effects. Circulating asprosin levels are elevated in a number of cardio-metabolic diseases, including obesity and type 2 diabetes mellitus. In vitro studies have reported pro-inflammatory effects of asprosin in pancreatic β-cells and skeletal muscle cells, which appear to be mediated via a toll-like receptor 4 (TLR4) mediated pathway, and m...

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

Variability in treatment response with respect to GLP1 agents is well-accepted but incompletely understood. In a specialist GLP-1 clinic at UHCW, we describe a case of improved therapeutic response following change in injection site. Currently, advice is injection in the abdomen or thigh.A 61 year old man was commenced on Liraglutide 1.2 mg subcutaneous OD injection, in 2013. Previously managed with glimepiride 4 mg and ...

Background: Hyperprolactinaemia is the common endocrine disorders. More commonly diagnosed in women due to menstrual irregularity, infertility and galactorrhoea. Hyperprolactinaemia can be due to many physiological stimuli such as stress, sleep, exercise, medications, primary hypothyroidism, renal failure, chest wall lesion. Stress of venepuncture can contribute to hyperprolactinaemia as well.Patient and methods: We conducted a retrospective analysis of ...

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >51.0 nmol/l) and azoospermia, hence the c...