Endocrine Abstracts

Background: Turner’s syndrome is the most common sex chromosome abnormality in females resulting from a 45,X cell line. A mosaic chromosomal complement (e.g. 45,X/46,XX) is detectable in over half of all patients with Turner’s. Characteristically girls with Turner syndrome have a short stature attributable to the presence of SHOX (short stature homeobox-containing gene on the X chromosome) gene. Most affected women have no pubertal development and primary am...

Tracheomalasia is extremely rare condition in Graves’ disease and may result in pneumomediastium with fistular formation from longstanding compression by a large goiter. There is no report that Graves’ disease combined with tracheomalasia and pneumomediastinum. A 24-year-old woman presented with abdominal pain, diarrhea and fever. On physical examination, a large goiter was detected on her anterior neck. Computed tomography of chest showed large amount of air in ante...

We report on a patient whose type 2 diabetes resolved following interferon-α (IFN-α) therapy for hepatitis C virus (HCV). A 57-years-old man, presented with fatigue, polyuria and polydipsia. He was newly diagnosed with type 2 diabetes. During the hospital day, he was also diagnosed with chronic hepatitis. Serological studies for chronic hepatitis demonstrated presence of hepatitis C, type 2a/2c genotype. He was started on subcutaneous insulin and IFN-α. After 24...

The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia was shown to modulate the level of ERα expression and induce ligand-independent transcriptional activation of ERα, which may be intimately associated with the biology of breast carcinomas. Given that phosphorylation affects the transcriptional activity and stabilization of ERα, we examined the changes in phosphorylation of ERα under hypoxic conditions. H...

Objective: The purpose of this retrospective study was to correlate BRAF (V600E) mutation with clinicopathological characteristics in papillary thyroid microcarcinoma (PTMC).Methods: We reviewed the clinical records of patients who were operated for a papillary thyroid microcarcinoma (PTMC) between May 2011 and October 2012 in Inje University Haeundae Paik Hospital. We investigated the prevalence of the BRAF (V600E) mutation, and relations between the pr...

Backgroud: The association with daily calcium intake and sarcopenia has not been well established.Objective: The objective was to assess the associate of daily calcium intake and sarcopenia.Methods: We analysed the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in old adult (over 50 years), conducted in 2009. A total of 1964 non-obese (body mass index (BMI) <25 kg/m2) old adults (871 men and ...

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...

Background: In Republic of Korea, prevalence of type 2 diabetes mellitus (T2DM) has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently associated with diabetes.Methods: We analyzed all subjects were T2DM patients over the age of 30 whose death certificates were issued at three hospitals in the Busan metropolitan area from 2010 to 2014. The causes of death were retrospectively determined based ...

Background: The COVID19 pandemic greatly affected the delivery of outpatient clinics. Tier 3 specialist weight management services (SWMS) aim to help obese patients lose weight through holistic lifestyle modification delivered by a multidisciplinary team consisting of specialist physicians, dieticians, physiotherapists, psychologists, and support workers. Prior to the pandemic, the service was delivered mainly through in person consultations. The nature of the pandemic necessi...

Background: Harmful effects of mercury on cardiovascular disease have been suggested in many epidemiologic studies. However, reports on harmful effect of mercury in relation to overweight or obesity have shown inconsistent findings.Methods: A total of 1577 children and adolescents (10–18 years of age) from the Korean National Health and Nutrition Examination Survey (KNHANES) 2009–2013. Overweight or obese group was defined as over the 85th perc...