Endocrine Abstracts

Introduction: Calbindin-D9k (CaBP-9k), which is a calcium ion buffering and transporter gene, is known to be regulated by the vitamin D and steroid hormones, and is mainly expressed in mammalian intestine, kidney and uterus. However, CaBP-9k expression in lung has not been studied. Maintaining lung structure using pulmonary surfactant is important for pulmonary gas exchange. Steroids are known to accelerate maturation of the fetal lung and secretion of surfactant. Otherwise th...

Pathological proliferation and migration of vascular smooth muscle cells (VSMCs) has been implicated in the pathogenesis of accelerated atherosclerosis in patients with diabetes mellitus. Increased aerobic glycolysis is a key feature of cellular phenotypes including cancer and immune cells. However, it remains largely unknown about the role of aerobic glycolysis in atherogenic phenotype of VSMCs. Here, we investigated the role of lactate dehydrogenase-A (LDH-A), which is a key...

Objective: To evaluate prevalence of chronic kidney disease (CKD) and risk factors for decline of renal function in elderly patients with type 2 diabetes (T2DM) after 6 years of follow-up.Methods: A cohort of 208 elderly patients (65 years or older) with T2DM participated in an examination during 2005, a 6-years follow-up examination during 2011. An estimated glomerular filtration rate (eGFR) was calculated using the modification of diet in renal disease...

Objective: To evaluate prevalence of chronic kidney disease (CKD) and risk factors for decline of renal function in elderly patients with type 2 diabetes (T2DM) after 6 years of follow-up.Methods: A cohort of 208 elderly patients (65 years or older) with T2DM participated in an examination during 2005, a 6-years follow-up examination during 2011. An estimated glomerular filtration rate (eGFR) was calculated using the modification of diet in renal disease...

Introduction: Women with diabetes mellitus (DM) are at increased risk of adverse maternal and foetal outcomes. Preconception planning is required to minimize risks, including good understanding of contraceptive options.Objectives: To determine in Australian women with DM beliefs regarding safety of various contraceptive methods in DM, information sources regarding contraception, recent and previous contraceptive use, knowledge of pregnancy risks, access ...

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. In previous study, demonstrated that endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) and Octylphenol (OP) could cause increase in insulin level and insulin transcription factors. But in regulations of plasma glucose level were not decreased as much as...

Introduction: Phthalates are chemicals used to improve the plasticity of industrial polymers and used in commercial products such as toys, paints, packaging materials, medicals devices and personal care items. Phthalates, endocrine disrupting chemicals, have been documented to cause adverse effects to the human health such as breast cancer in female, reduced uroogenital distance and changed the expression of steroidogenesis and folliculogenessis. In this study, we investigated...

Background: Recently, diabetic mortality is lower than ever before, likely due to dramatic improvements in diabetes care. This study set to analyze changes in the cause of death in type 2 diabetes mellitus (T2DM) in the past 20 years.Methods: All subjects were T2DM patients over the age of 30 whose death certificates were issued at six hospitals in the Busan metropolitan area from 2010 to 2014. The patients were excluded if they had been clinically diagn...

Objective: Hypoglycemia is a common adverse event and one of the main obstacles to achieving good glycemic control to minimize the risk of diabetic complications in patients with diabetes. Therefore, most physicians try to reduce hypoglycemia events through education about hypoglycaemia, such as diabetes self-management education. In this study, we surveyed the actual insight about hypoglycemia, behavior of diabetic patients to avoid hypoglycemia and the fear of hypoglycemia.<...

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant condition characterized by the presence of a medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. The germ-line mutations of the RET proto-oncogene cause MEN2A. Specific RET mutations correlate with the onset of age and the aggressiveness of the disease. It has been reported that polymorphisms of RET may have a modifier effect on the presentation.Case re...