Endocrine Abstracts

Background and Aim: The triglyceride glucose (TyG) index has been proposed as a marker of insulin resistance. This study aims to evaluate the utility of the TyG index in routine practice for predicting diabetes, prediabetes, and metabolic dysfunction-associated fatty liver disease (MAFLD) in obese individuals.Methods: The study retrospectively analyzed data from obese individuals at our outpatient clinic. The study recorded patient characteristics such a...

Objective: Motilin is a proximal small intestinal hormone with roles in gastrointestinal motility, gallbladder emptying and hunger initiation. The molecular mechanisms underlying motilin release in response to fats, bile and duodenal acidification are poorly understood, in part due a lack of suitable cellular and rodent models. We therefore generated a novel human intestinal organoid model with fluorescently labelled motilin-expressing M-cells, which we used to establish the k...

Objective: Age-associated double negative (DN) B memory cells lacking surface expression of CD27 and immunoglobulin D (IgD) are associated with proinflammatory characteristics and higher disease activity in autoimmune diseases. We first characterized B cells phenotypes in women with and without polycystic ovary syndrome (PCOS). We then took an in vivo approach, transferring purified IgG extracted from serum of hyperandrogenic women with PCOS to mice to establish wheth...

Introduction: Brown tumor refers to the skeletal change that develops as one of the complications of hyperparathyroidism, in which cystic and fibrous changes occur in the bone. It occurs in approximately 10−20% of patients with primary hyperparathyroidism. Parathyroid cancer is a rare cause of primary hyperparathyroidism and accounts for approximately 1% of cases. In some cases, hyperparathyroidism may be asymptomatic until it becomes a pathological fracture and may be t...

Introduction: Hemichorea-hemiballismus, secondary to hyperglycemia, is a rare but easily treatable condition that is usually associated with poorly controlled type II diabetes mellitus. Diagnosis is based on clinical assessment and imaging. Etiology includes primarily cerebrovascular diseases, metabolic, degenerative, infectious diseases, space-occupying lesions, basal ganglia damage due to drugs and toxic substances.Case: Here we report a rare case of a...

Introduction: Ectopic neurohypophysis is a congenital abnormality related to faulty embryogenesis resulting in incomplete caudal extension of the infundibulum. It may present itself with symptoms of growth hormone deficiency or panhypopituitarism and patients require replacement treatment for panhypopituitarism.Case Presentation: Our female patient was shorter (138 cm) than her peers and did not menstruate at the age of 19 when she first...

Introduction: The hyperandrogenic in utero environment in pregnant women with polycystic ovary syndrome (PCOS) can affect embryo development and impair offspring health at adult age. Moreover, long term hyperandrogenic exposure also leads to unfavored changes to the mothers’ reproductive physiology, leading to miscarriage, preterm delivery, and perinatal mortality. The underlying mechanism(s) of pregnancy complications associated with PCOS and the consequence of ...

Introduction: The prevalence of diabetes mellitus (DM) continues to increase worldwide. Diabetic retinopathy (DRP) is one of the most common complications of Type 2 DM. Recently, the effect of thyroid hormones on diabetic microvascular complications has gained much attention. This relationship is explained by the important effects of thyroid hormones on endothelial function. There are studies investigating the relationship between TSH and diabetic nephropathy and DRP. There ar...

Introduction: Superior mesenteric artery (SMA) syndrome is a rare cause of abdominal pain due to proximal intestinal obstruction which is characterized by compression of the third portion of the duodenum secondary to the narrowing of the space between the superior mesenteric artery and aorta. The development of the SMA syndrome is primarily attributed to the loss of the intervening mesenteric fat. Lipodystrophy is a rare clinical syndrome characterized by the loss of adipose t...

Central nervous system involvement is observed in 5-14% of Behçet’s disease and this form is called neurobehçet syndrome (NBS). There are two main forms of CNS involvement in Neurobehçet syndrome, in which parenchymal involvement and vascular involvement are prominent. Cerebral venous thrombosis (CVT), the most prominent form of vascular involvement, has been reported in 8% in Behçet’s disease and in approximately 18% in NBS. Although CVT is the m...