Endocrine Abstracts

Objectives: Various systemic symptoms may occur in patients with thyrotoxicosis. Gastrointestinal manifestations such as hyperphagia or frequent defecation, often coexist with other thyrotoxic symptoms. Vomiting also has been mentioned.In this setting, systemic symptoms of underlying malignancy may be confused with those of thyrotoxicosis leading to a delay in diagnosis.Methods: We report a case with delayed diagnosis of small bowe...

Background: Cortisol profiles during treatment with standard hydrocortisone (StdHC) formulations are unphysiological. Some patients, with low cortisol levels between doses, experience symptomatic hypocortisolaemia and may benefit from modified release hydrocortisone (MRHC). Plenadren is a MRHC licensed for once daily dosing in adults.We offered Plenadren to patients with symptomatic hypocortisolaemia, documented to occur at times of low cortisol levels, ...

Glucagon-like peptide-1 (GLP-1) is known to stimulate insulin and somatostatin secretion in pancreatic islet cells. The exogenous somatostatin inhibits insulin secretion, but GLP-1 increases insulin secretion in spite of stimulating somatostatin secretion from δ-cell. So, we investigated whether there exists a time difference of insulin and somatostatin secretion inside the islets after GLP-1 stimulation or insulin secretion depends on secreted GLP-1 or somatostatin conce...

Background: The risk of iodine-induced thyrotoxicosis is increased in patients with Graves’ disease and multi nodular goiter with thyroid autonomy. At same time, hypothyroidism can develop after iodine exposure in patients with Hashimoto’s thyroiditis. But, there are no studies about the influence of iodine containing contrast media on thyroid function in iodine excessive area. This study was done to evaluate the changes of thyroid function after coronary angiography...

Aims: HDL have many diverse functions. The goal of this study was to determine the differential effect of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) on the development of type 2 diabetes (T2D). In addition, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D.Methods: A total of 27 988 subjects with impaired fasting glucose (IFG) (18 266 men and 9722 women) aged 21 to 91 years (mean age 43.5 years)...

Objective: The association between albuminuria and peripheral artery disease (PAD) could be confounded by renal function. Albuminuria reflects generalized disruption of endothelial cell function. This study was conducted to examine the association of PAD with low glomerular filtration rate (GFR) and albuminuria in diabetic patients.Methods: A total of 254 diabetic patients were included. We examined the age, sex, duration of diabetes, GFR, urinary albumi...

Introduction: There are few cases about arterial thrombosis combined with thyrotoxicosis independent of atrial arrhythmias. Herein, we report a case of Graves’ disease presented with renal artery infarction withiout atrial fibrillation.Case: A 54-year-old man visited the emergency department due to the sudden onset of left flank pain for 30 min. The left flank pain was accompanied by sole dysuria without other symptoms of pyelonephritis. Physical ex...

Introduction: The degree of dyslipidemia caused by iatrogenic hypothyroidism is not clear in DTC. Therefore, we investigated the average of lipid profile change caused by LT4 withdrawal in the follow-up of DTC.Method: We enrolled 84 DTC patients who underwent high-dose RAI therapy for the treatment of recurred or remnant DTC and we measured serum levels of total cholesterol, triglyceride, LDL, and HDL and then analyzed changes in them accordin...

Hypoxia causes oxidative stress and is known to affect cardiovascular dysfunction and the programming of cardiovascular disease. Melatonin is the hormone released primarily from the pineal gland and has been proven to be an antioxidant. Melatonin promotes the expression of antioxidant enzymes such as superoxide dismutase and catalase. To confirm the effect of hypoxia on the differentiation of mouse embryonic stem cells (mESCs) into cardiomyocytes, hypoxia condition induced dur...

Developmental toxicity tests have been made by embryonic stem cell tests at the European Centre for the Validation of Alternative Methods or by embryonic body test in our laboratory. However, no neuronal-specific developmental toxicity test has been made yet. Therefore, this study was carried out using a 46C cell line, mouse embryonic stem cells with an endogenous Sox1-GFP reporter, to exploit the developmental neurotoxicity test. The expression of Sox1, a marker for neural pr...