Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp107 | Diabetes Translational | ECE2018

Cumulative effect of glucose regulation in Calbindin-D9k knockout mice

Jeung Eui-Bae , Ahn Changhwan , Jeon Bo Hui , Park Seon Young , Ly Duc Viet

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, ...

ea0056p412 | Diabetes complications | ECE2018

An association of non-alcoholic fatty liver disease and autonomic neuropathy parameters in patients with type 2 diabetes

Kim Yu Ji , Lee Kyung Ae , Jin Heung Yong , Park Tae Sun

Background: Non-alcoholic fatty liver disease (NAFLD) is metabolic disorder of the liver that is associated with type 2 diabetes.The relationship between NAFLD and diabetic neuropathy was still poorly understood. This study aimed to investigate whether the NAFLD is associated with the autonomic neuropathy parameters in patients with type 2 diabetes.Methods: A total of 174 patients with type 2 diabetes were included in this study. Patients were divided in...

ea0056p574 | Obesity | ECE2018

Novel indicator of abdominal obesity strongly associated with cardiovascular disease

Kim Dong Sun , Park Jung Hwan , Ryu Ohk-Hyun , Chung Wankyo , Moon Shinje

Obesity is one of the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity. Several indicators of abdominal obesity such as body mass index (BMI) and waist circumference (WC) are available. BMI and WC have limitations in stratifying cardio-metabolic risks. Another obesity measure, A Body Shape Index (ABSI), has been introduced but its applicability remains limited. To address this, the z-score of the log-transformed ABSI (LBSIZ) was recently develope...

ea0073aep588 | Reproductive and Developmental Endocrinology | ECE2021

Establishment of an assay for the effects of neurodevelopmental toxicity using Sox1-GFP cells

Jeong Sunhwa , Park Seon Mi , Go Seon Myeong , Nam Tran Dinh , Lee Jimin , Eui-Bae Jeung

Developmental toxicity tests have been made by embryonic stem cell tests at the European Centre for the Validation of Alternative Methods or by embryonic body test in our laboratory. However, no neuronal-specific developmental toxicity test has been made yet. Therefore, this study was carried out using a 46C cell line, mouse embryonic stem cells with an endogenous Sox1-GFP reporter, to exploit the developmental neurotoxicity test. The expression of Sox1, a marker for neural pr...

ea0073aep618 | Reproductive and Developmental Endocrinology | ECE2021

Effects of mitochondrial dynamics during myocardial differentiation in 3D model

Jeong Sunhwa , Lee Minsu , Mi Park Seon , Lee Jimin , Eui-Bae Jeung

Mitochondria, which are essential organelles for endocrine health, plays an important role in various physiological functions including hormonal biosynthesis, cell metabolism, proliferation and differentiation. Thus, mitochondrial toxicity can affect a variety of organs, such as liver, heart, muscle, kidney, and central nervous system. Mitochondrial toxicity is recognized as a contributor to drug-induced toxicity of various drugs such as hydroxytamoxifen, valproic acid, acetam...

ea0092ps1-01-08 | Cancer | ETA2023

Significance of bilaterality and multifocality in papillary thyroid cancer

Hyang Jung Jin , Wook Kim Wan , Lee Jeeyeon , Yong Park Ho , Keum Heejung , Kang Byeongju

Purpose: Papillary thyroid cancer (PTC) has a strong propensity for lymph node metastasis, which is related with local recurrence, and disease-specific survival in the elderly. We evaluated the association between lymph node metastasis and disease multifocality, bilaterality, and other clinicopathological variables to identify risk factors and aid surgical decision-making. The relationship between the number of foci and metastasis to cervical lymph node was also evaluated....

ea0092ps1-04-02 | Nodules-surgery | ETA2023

Early voice problems assessment in post-thyroidectomy syndrome using vocal fatigue index and cepstral analysis

Kim Heejin , Seob Lee Joong , Keum Bo-Ram , Eun Kim Ju , Park Il-Seok

Post-thyroidectomy syndrome is defined as postoperative problems after thyroidectomy without injury of recurrent laryngeal nerve, and including most common symptom such as vocal fatigue, loss of high-pitch, reduced vocal strength, reduced speaking fundamental frequency also can be presented. In a recent systemic review, F0, shimmer, and MPT was significantly deteriorated only in the early period and not in the late period after thyroidectomy. There have been several questionna...

ea0092ps1-08-04 | Translational 1 | ETA2023

Association between BMI and Brafv600E mutation status may differ by primary tumor size

Park Hyunju , Heo Jung , Jin Ryu Hyun , Hyuk Kim Tae , Wook Kim Sun , Hoon Chung Jae

Introduction: The prevalence of B-type Raf kinase (BRAFV600E) mutation in PTC has been observed in 30% to over 80%, and it seems that the mutation occurred in the early stage of thyroid carcinoma progression which precedes histological change. Based on previous reports, high body mass index (BMI) is considered a thyroid cancer risk. However, it is unclear whether high BMI has a certain association with the BRAFV600E mutational status. We assess whether high BMI is associated w...

ea0092ps2-13-04 | Surgery | ETA2023

Multifocality is not a risk factor for recurrence after thyroid lobectomy: A study of 1,684 patients with differentiated thyroid cancer

Kyung Kim Hee , Cho Jin-Seong , Yong Park Ji , Choi Wonsuk , Ram Hong A , Kang Ho-Cheol

Background: We evaluated the impact of the multifocality on post-lobectomy recurrence in patients with differentiated thyroid cancer (DTC).Methods: We analyzed 1,684 patients with DTC who underwent thyroid lobectomy from 2008 to 2015 using logistic regression models to calculate the relative risk on post-lobectomy recurrence.Results: Tumor diameter increased from 4.9 mm to 8.1 mm and the proportion of extrathyroidal extension (ETE)...

ea0095oc2.2 | Oral Communications 2 | BSPED2023

Conquering the Storm: Surgical Intervention Rescues an Adolescent girl with Severe Thyrotoxicosis Refractory to Medical Management

Mehta Sajili , Ramya Gokul Pon , Ankur Raj , Lau Katherine , Park Julie , Dharmaraj Poonam

Introduction: Graves’ disease (GD), although the most common cause of hyperthyroidism, is relatively uncommon in children, usually manifesting insidiously. Thyroid storm is a well described but rarely seen phenomenon in childhood GD; thyrotoxic crisis is less often discussed and its management can be challenging. We describe a case of GD with thyrotoxic crisis.Case: A 14-year-old female, known to have inadequately c...