Endocrine Abstracts

TIM16, a protein of the translocase complex TIM23 of the mitochondrial inner membrane, is encoded by the Magmas a gene. Magmas silencing has been associated with a greater sensitivity to apoptotic stimuli in pituitary adenoma cell lines. We recently demonstrated that in a human medullary thyroid carcinoma cell line (TT) compound 5, a TIM16 inhibitor, was not cytotoxic but enhanced the proapoptotic effects of staurosporine. The aim of our study is to verify whether mithocondria...

TIM16 a component of the translocase complex TIM23 of the mitochondrial inner membrane is encoded by the Magmas gene. Magmas was found to be over-expressed in human pituitary adenomas. Silencing Magmas in ACTH secreting rat pituitary adenoma cells enhances sensitivity to pro-apoptotic stimuli. Moreover, Magmas overexpression protects GH secreting rat pituitary adenoma cell lines towards apoptosis. Recently, we found that compound 5, a TIM16 inhibitor, is not cytotoxic but enha...

Rationale: Our aim has been to describe the assistance demand and the profile of patients treated in the eating disorders unit in our hospital.Methods: Observational retrospective study (reviewing medical histories).Results: One thousand two hundred and fourteen patients have been treated at the eating disorders unit between 1996 and 2012, 91.8% female. Age at first visit: 22.1±8.3 years. Time of monitoring tracking: 1.2±...

Introduction: It has been suggested that the lack of exposure to low ambient temperatures may be a contributor to the development of obesity. The aim of this study was to study possible associations between climate and the risk for obesity in the Spanish population using an ecological focus.Methods: The [email protected] Study is a national epidemiological study designed to determine the prevalence of diabetes, obesity and other cardiovascular risk factors in Sp...

Background: Pegvisomant(PegV) and Pasireotide LAR(Pasi) are commonly used in acromegaly patients resistant to first-generation SRLs. Predictors of response to therapy with PegV and Pasi in this subset of patients are still unclear. These findings may be useful in choosing the most appropriate therapeutic option for the personalized treatment of patients affected by more aggressive disease. We aimed to identify individual predictors of responses.Methods: ...

Introduction: In patients with human immunodeficiency virus (HIV) infection, the prevalence of osteoporosis is higher in comparison with the general population. Anti-retroviral therapy (ART) use seems to be a possible risk factor there is also high prevalence of vitamin D deficiency among people living with HIV.Objectives: To describe bone mineral density (BMD) status in HIV-infected patients as well as its associated risk factors such as vit D levels.</...

Objectives: MODY diabetes is the most common form of monogenic diabetes, encompassing a heterogeneous group of disorders whose primary defect results from mutations in one of at least seven genes recognized, associated with a primary defect in insulin secretion. It has early onset and autosomal dominant inheritance.Our objective was to evaluate the results of monogenic diabetes clinic of the Endocrinology and Nutrition Department during 2008–2012.</...

Background: So far, guidelines for bariatric surgery do no recommend the universal screening for thyroid diseases, except the TSH measurement in selected patients. However, a possible interplay between obesity (possibly complicated by obesity-related comorbidities) and thyroid diseases has been postulated.Objective: Aim of the study was to investigate the prevalence of thyroid diseases in a cohort of obese patients, evaluated for bariatric surgery. Metho...

Background: Acromegaly is a rare endocrine disorder characterised by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1) that is associated with significant morbidity and impaired quality of life (QoL). Standard-of-care (SoC) treatments for acromegaly typically require healthcare provider administration, pose a substantial treatment burden, and leave scope for improved disease control. CAM2029, an octreotide subcutaneous depot with ~5x higher bioavailability th...

Background: Acromegaly is a neuroendocrine disorder, characterised by growth hormone (GH) and insulin-like growth factor 1 (IGF-1) overproduction. Persistent biochemical control to minimise adverse effects of prolonged excess GH/IGF-1 is a key treatment goal. CAM2029 is a novel octreotide depot, designed for convenient monthly subcutaneous self-administration, using pre-filled syringes/injection pens. A 24-week Phase 3 trial (ACROINNOVA 1, NCT04076462) evaluated CAM2029 in pat...