Endocrine Abstracts

A 59-year-old woman with 46XY complete androgen insensitivity syndrome was referred back to our service. She also has history of hypertension and migraines. She was gonadectomised at the age of 15 years and treated with Ethinylestradiol. She married and was able to have enjoyable sex without the need for vaginoplasty or dilators. However, at 54 years she was firmly advised to stop Ethinylestradiol due to satisfactory bone density and “risks of HRT outweighing benefits&#14...

Case history: We report an interesting case of a rare cause of hypopituitarism where our patient presented to the hospital with acute onset headache, vomiting, and feeling generally unwell. Investigations/Results: On routine bloods, he was found to have hyponatremia. On further workup of hyponatremia, he had low morning cortisol which was confirmed as secondary adrenal insufficiency on dynamic function testing. He was also deficient in gonadotrophins alo...

Introduction: Historically there are many examples of doctors using language which does not aid joint decision making with patients. At medical school we are taught to find out the presenting complaint rather than the reason for attendance. We write about non-compliance with treatment in the medical records rather than barriers to adherence. Similarly we use language in the Diabetes clinic which can disempower the children and families who attend our clinics.<p class="abst...

Sarcoidosis is a multiorgan disease often affecting the lungs and lymphatic system. Neurological involvement occurs in sarcoidosis as granulomas infiltrate the nervous system. Here, we present a case of neurosarcoidosis diagnosed following non-specific neurological symptoms and delayed hypercalcaemia. A 32-year-old female presents with headaches, vomiting and acute confusion. During admission she developed unresponsive episodes. She has a background of type 1 diabetes and hypo...

Introduction: Definitive treatment of hyperthyroidism with Radioactive Iodine (RAI) ablation therapy has been associated with weight gain from RAI induced hypothyroidism. Literature on weight data of post-RAI patients following normalisation of thyroid function is equivocal.Objective: We undertook a retrospective study to evaluate the effect of RAI on weight in Hyperthyroid patients in University Hospitals of Leicester NHS Trust (UHL). <p class="abst...

Adrenal haemorrhage is a serious condition that can result in adrenal insufficiency, shock, acute adrenal crisis, and mortality if not managed with adequate treatment. Hereby we present two cases of non-traumatic bilateral adrenal haemorrhage highlighting their management during the acute phase.Case 1: 57 year old female presented due to chest pain, palpitations and troponin rise with a background history of antiphospholipid syndrome on anticoagulation. ...

Introduction: Brown tumors or osteitis fibrosa cystica are benign bone tumors complicating uncontrolled primary or secondary hyperparathyroidism. They may behave aggressively and can be destructive. Their osteolytic aspect may be misinterpreted as skeletal metastases.Methods: A 37-year-old female patient with chronic renal failure on dialysis, presented with pain and swelling of her left knee for 10 days, with no associated trauma. She gave history of tu...

Background: Cardiovascular disease (CVD) is a leading cause of mortality. Childhood obesity is a major contributor to CVD. Atherogenic index of plasma (AIP) is an indicator of risk of atherosclerotic CVD. Associations between childhood obesity and CVD risk in the region remains under-explored. We aim to investigate this association as a predictor of CVD in this young population.Methods: Patients who attended our Centre (2009-2019), age ≤19 years an...

Background: The obesity prevalence surge in children and adolescents is associated with dysglycaemia, dyslipidaemia and long-term cardiovascular complications. Use of lipid-lowering medications1 has been recommended following lifestyle modifications. We aim to investigate the demographic, and changes in LDL-c, in these young patients, in the presence and absence of dysglycaemia.Methods: Complete lipid profiles of patients (≤19 years old)...

Introduction: We report the case of a patient with corticotropic insufficiency associated with diabetes insipidus who presented to the emergency room with profound hyponatremia; a complicated situation, whose solution was hidden in the galenic form of Desmopressin.Case report: Mrs Y. Amina, 37 years old, has been followed for 10 years for a non Langerhansian histiocytosis of pituitary location, complicated by a corticotropic insufficiency under hydrocort...