Endocrine Abstracts

Background: Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are commonly characterized by overexpression of somatostatin receptor subtype 2 (SSTR2), which can be targeted by radiopharmaceutical therapy (RPT) via radiolabeled somatostatin analogues (SSAs). RYZ101 (Ac-225 DOTATATE) is a first-in-class, highly potent alpha-emitting RPT being developed for the treatment of SSTR2+ solid tumors. Alpha-particles (such as emitted by Actinium-225) have a sho...

Introduction: Mutation in PROP1 gene is the cause of different forms of pituitary dysfunction. The assessment of the functioning of the adrenal axis still raises the most doubts.Aim& methods: A retrospective longitudinal (mean 35 years, SD 16.24) analysis of 32 patients (19W/13M, including 5 families and sporadic cases) with PROP1 mutation was performed to define the optimal diagnostic approach in evaluation of adrenal axis. In the study morning cort...

Background: Despite increased awareness among cardiologists about the risk of amiodarone’s significant side effects, it is still a commonly used antiarrhythmic drug. Amiodarone may induced easy for management hypothyroidism which affect even 25% of patients or less frequent thyrotoxicosis (AIT) which causes a challenge for clinicians. Type 1 of AIT occurs on the basis of pre-existing thyroid diseases such as nodular goiter or latent Graves’ disease, type 2 results fr...

Background: The excessive secretion of parathormone by parathyroid glands is a common disorder known as hyperparathyroidism. With a prevalence of 0.1-0.4 percent in the general population and 2-4 percent in post-menopausal women, primary hyperparathyroidism is the third most frequently reported endocrine disorder. According to estimates, the prevalence of primary hyperparathyroidism has escalated in recent years, probably due to the increasing rate of parathormone and calcium ...

Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective treatments for type 2 diabetes and obesity. We recently described ‘biased’ peptide GLP-1R agonists modelled on exendin-4 which uncouple the pronounced endocytosis that usually accompanies GLP-1R activation, leading to prolongation of intracellular signalling responses. Here, we show that the metabolic consequences of biased GLP-1R activation in vivo are dominated by improvements in blood glucos...

Objective: The thyroid fine needle aspiration biopsy (FNAB) may bring inconclusive cytological results of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) or follicular neoplasm/suspicious for follicular neoplasm (FN/SFN). The objective of the study was to describe the genetic landscape of indeterminate thyroid nodules to better understand this phenomenon and identify genetic markers potentially differentiating benign and malignant ...

Introduction: Germline mutations of RET oncogene result in development of multiple endocrine neoplasia type 2 (MEN 2). There is a strong correlation between type of the RET sequence changes and the aggressiveness of main syndrome feature, medullary thyroid carcinoma (MTC), and the incidence of remaining manifestations, mainly pheochromocytoma (PHEO). For many of the RET germline mutations, the clinical risk have been precisely defined, but there are ...

The role of adjuvant external beam radiotherapy (EBRT) in differenciated thyroid cancer (DTC) is controversial. It remains unknown whether EBRT in the neck following conventional treatment might improve progression-free survival (PFS) and overall survival (OS).Objective: To assess EBRT outcomes in patients with locally advanced DTC in terms of local disease progression, PFS and OS.Material and Methods: A multicentric retrospective ...

Background: Pituitary stalk lesions (PSL) are various changes located in the pituitary infundibulum. The underlying pathology and exact diagnosis are difficult to establish due to their difficult anatomical locus.Aim: To present the etiological spectrum of pituitary stalk lesions and their clinical and hormonal characteristics on the basis of long term observation in the pediatric/adult endocrinology departments of our university.M...

Introduction: The aim of the present study was to compare follicular thyroid adenoma (FTA) and follicular thyroid carcinoma (FTC) using the wide oncological molecular panel and identify differences in mutational status which may aid in the preoperative differentiation between these two related thyroidal pathologies, as well as in an understanding their pathways of origin.Material and methods: We analyzed formalin-fixed paraffin-embedded (FFPE) samples ac...