Endocrine Abstracts

Background: Salivary biomarkers are attractive diagnostic tools for paediatric practice, enabling non-invasive sampling at home. Salivary cortisol (SCl) and cortisone (SCn) are sensitive markers of adrenal insufficiency during inhaled corticosteroid treatment(1). SCn is reported to be the best correlate of plasma cortisol. Measurements of SCl may not be necessary, reducing cost and sample volumes.Eleven beta hydroxysteroid dehydrogenase type 2...

Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency.Methods: One hundred and five patients with type 2 diabetes were divide...

Objective: Cilostazol, a selective inhibitor of phosphodiesterase 3, which has been widely used in patients with atherosclerotic diseases, is known to have additional beneficial effects on dyslipidemia. ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the regulation of intracellular cholesterol levels in hepatocytes. We aimed to investigate the effect of Cilostazol on hepatic steatosis and its underlying mechanism related to ABCA1.Met...

Background: Recent studies have shown associations of thyroid hormone levels with metabolic syndrome (MetS) among euthyroid individuals, though there have been some inconsistencies. We evaluated the relationships between thyroid hormones and MetS in euthyroid middle-aged subjects in a large cohort.Methods: Retrospective analysis of 13 496 euthyroid middle-aged subjects who participated in comprehensive health examinations was performed. Subjects were gro...

A new genetic disorder has recently been identified that results from mutation of THRA, encoding thyroid hormone receptor α1 (TRα1). Affected children have a high serum T3:T4 ratio, constipation and a variable intellectual deficit, but exhibit a consistently severe skeletal dysplasia. Similar to these patients, Thra1PV/+ mice harbour a mutation that disrupts the C-terminal α-helix of TRα1 and express a domi...

Aim: Suicide and depression are one of the highest public health problems worldwide. Suicidal ideation represents an important phase in the suicidal process and often precedes suicidal attempts or completed suicide. Patients with chronic medical disease are more likely to report suicidal thoughts and depression. However the studies on relationship between these conditions and metabolic syndrome are rare. We aimed at investigating the prevalence of depression and suicidal ideat...

Introduction: Rutin (C27H30O16) is the major representative of the flavonol subclass of flavonoids. Rutin has wide variety of pharmacological activity, however there are not sufficient data in 3T3-L1 preadipocyte. In this study, we demonstrated that the effect of rutin on the proliferation of 3T3-L1 preadipocyte.Methods: The 3T3-L1 preadipocyte were treated with homocysteine (1 mM), rutin (30 μM) and rutin after homo...

Background: The body mass index (BMI) is the most widely used method of assessing fat accumulation, and is recognized as an independent risk factor for cardiometabolic diseases. However, there might be substantial variations in the fat or muscle amount among persons with a similar BMI. The aim of the present study was to investigate whether BMI and skeletal muscle mass (SMM) estimated from by bioelectrical impedance analysis (BIA) are associated with carotid atherosclerosis in...

Introduction: Calbindin-D9k is a 9 kDa polypeptide expressed in the mammalian intestine, uterus, and pituitary gland. Calbindin-D9k increase Ca2+ absorption by buffering intracellular Ca2+. The intracellular concentration of calcium is regulated by calcium related proteins such as calbindin-D9k, TRPV1 and PMCA1. The regulatory effect of steroid hormones and glucocorticoids on calbindin-D9k, TRPV1 and PMCA1 expre...

Background: BoneXpert software calculates bone health index (BHI) from 100 measurements of cortical thickness and mineralisation of three metacarpals. BHI-SDS is derived from 3,121 X-rays from 231 healthy Caucasian children, corrected for bone age (BA), estimated from the same x-ray.BHI-SDS is new with relatively unknown clinical utility. Strong correlations between BHI and dual-energy x-ray (DXA) absorptiometry and peripheral quantitative computed CT me...