Endocrine Abstracts

Objective: The carbohydrate metabolism dysfunctions are common in critical ill patients with diabetes or stress hyperglycaemia and the correct management of them has an important prognostic value. Despite its limitations, capillary glucose (CG) was collected more than arterial glucose (gold standard) because of its good correlation. However, the usefulness of intermittent intersticial glucose monitoring (IGM) in keeping blood glucose within target range in critical ill patient...

Introduction: Generously supported by IPSEN)-->Prolactin (PRL) -secreting adenomas are about 40% of all pituitary adenomas. Their clinical symptoms are mainly related to development of secondary hypogonadism and/or tumor mass effects. Dopamine agonists (DA) are first-line drugs for prolactinoma patients due to their effectiveness in normalizing PRL levels and shrinking tumour mass. Surgery is an option for DA failure or tumour mass e...

Fine-needle aspiration cytology (FNAC) remains the mainstay in the study of thyroid nodules, with cytologic adequate specimens in almost 85% of cases in expert hands. Apart from the limitation of inadequate samples, there are false negative diagnoses in some cases, particularly in larger (>3 cm) nodules. Considering this, Large-needle biopsy (LNB) could be useful to improve diagnostic precision. We review the pathology reports (PR) of more than 100 patients operated since ...

Objective: The definitive treatment of primary hyperparathyroidism (PPH) is the removal of the affected gland(s). However, its localization can be complicated. The usefulness of 18F-Choline PET-CT versus classical techniques is unknown. The aim of this study was to evaluate the results of 18F-Choline PET-CT in the detection of hyperfunctioning parathyroid tissue with respect to conventional imaging tests and to analyze the relationship between its findings and the levels of ca...

Introduction and objectives: Diabetic ketoacidosis (DKA) is a severe acute complication of Diabetes Mellitus (DM) and may require hospital admission. Our aim was to compare the characteristics of DKA occurring in patients with autoimmune DM (AMD) and type 2 DM (DM2) in our setting.Methods: Retrospective observational study. Patients with AMD and DM2 admitted for DKA at the Hospital Universitario San Cecilio de Granada between January 2019 and December 20...

Background: Previous studies of association between maternal thyroid autoimmunity and adverse pregnancy outcomes have produced inconsistent results.Objective: To examine whether thyroid autoimmunity detected at first trimester screening is predictive of a range of adverse obstetric and fetal outcomes.Patients and methods: We studied 438 women with singleton pregnancies who underwent first trimester screening test between June and J...

Aims: To study if BRAF V600E mutation in thyroid fine needle aspiration (FNA) is associated with specific ultrasound (US) characteristics.Patients and methods: From 2010 to 2014 we reviewed patients with thyroid nodules with the following inclusion criteria: US guided FNA of the nodule and molecular testing for BRAF V600E on the FNA. BRAF mutation was detected using fluorescence melting curve. An expert on US, blinded to the BRAF status reviewed US exami...

Introduction and objective: Prophylactic central lymph node dissection (CLND) in patients with suspected papillary thyroid cancer (PTC) without evident lymph node metastasis (LNM), remains debatable. We propose to evaluate whether BRAF V600E mutation presence, could help to identify patients at risk for LMN.Methods: Retrospective study of patients with diagnosis of PTC, who underwent total thyroidectomy during 2002 and 2013 (n: 256) in our hospi...

Undifferentiated thyroid carcinoma is a highly aggressive human cancer with poor prognosis. A strong association has been observed between undifferentiated thyroid carcinoma and TP53 mutations. Plitidepsin (AplidinTM) a novel anticancer compound from a sea tunicate, has been reported to induce apoptosis independently of TP53 status. We investigated the actions of plitidepsin in human thyroid cancer cells. initiallyexperiments using primary cultured cells from a d...

Introduction and objectives of the study: Every year the Diabetes Association of Granada (AGRADI), organizes a summer camp for children with Diabetes Mellitus type 1 with the aim of combining leisure activities and facilitating learning and developing autonomy in their pathology. The presence of health professionals is essential to ensure the monitoring and safety of children and a good diabetological education. The aim of this study is to evaluate the clinical characteristics...