Searchable abstracts of presentations at key conferences in endocrinology

ea0003p97 | Diabetes & Metabolism | BES2002

The expression of resistin mRNA in human adipose tissue

McTernan P , McTernan C , Lauer M , Barnett A , Kumar S

Resistin, a novel signalling molecule isolated in mice, has been suggested to be the putative hormone thought to link obesity with type 2 diabetes. As central obesity is associated with a higher risk of diabetes, we compared resistin mRNA expression in abdominal fat depots to thigh and breast adipose tissue. Mononuclear cells are also known to expression resistin, therefore, CD45 expression (a marker of mononuclear blood cells), was also analysed. RNA was extracted from 32 hum...

ea0003p242 | Signalling | BES2002

Essential role of p38 mitogen-activated protein kinase in adipogenesis

Patel N , Holder J , Smith S , Kumar S , Eggo M

Human obesity is characterised by an increase in both the number of adipocytes and by an increase in their size, which is determined by adipogenesis. Adipogenesis can be induced in vitro in preadipocytes cultured in differentiation medium containing 3-isobutyl-1-methylxanthine, insulin, dexamethasone, and triiodothyronine but the signalling pathways important in adipogenesis are not well characterised. The p38 mitogen-activated protein kinase (MAPK) signalling pathway i...

ea0003p277 | Thyroid | BES2002

Influence of pre-treatment factors on outcomes following the use of high fixed dose radioiodine treatment for hyperthyroidism

Barton D , Buch H , Baskar V , Kumar H , West T

Radioiodine therapy (RAI) is widely used as definitive treatment for hyperthyroidism. Of the several regimes in use, we have used a standard 555 MBq dose of RAI to treat all patients with hyperthyroidism. Treatment is considered to have failed if patients remain hyperthyroid at 12 months and a repeat 555 MBq dose is administered. We have studied 584 consecutive patients for failure rate of RAI when it is used according to this regime (mean follow-up 3 years (range 1-10)). We h...

ea0094p41 | Bone and Calcium | SFEBES2023

Tumour-to-tumour metastasis to the parathyroid causing dual pathology hypercalcaemia

Sankar Adhithya , Brindle Rachel , Tymms James , O'Connell Ian , Kumar Mohit

An 85-year-old woman attended the endocrine clinic with hypercalcaemia and raised PTH levels. Her background included breast cancer treated with bilateral mastectomy and hormone therapy 3 years previously, with no evidence of disease on imaging 2 years previously. On attendance, her clinical examination was unremarkable, with no palpable neck mass. Biochemical investigations showed: Adj Ca 3.12 mmol/l, PTH 45.0 pmol/l, PO4 0.94 mmol/l, ALP 119U/l, Alb 45g/l, 25-OH Vit D 15.7 n...

ea0094p72 | Metabolism, Obesity and Diabetes | SFEBES2023

Correlation of metabolic syndrome with human papilloma virus infectivity in pregnant women

Gupta Amrit , rani Shuchi , Singh Nidhi , Kumar Anoop , Tiwari Swasti

Human papillomavirus (HPV) is one of the most common sexually transmitted viruses in reproductive age. About 80% of women will get at least one type of HPV at some point in their lifetime. Pregnancy is highly susceptible because decreased immunity during this period. There are few studies available from Indian sub-continent indicating a link between HPV infection and pregnancy. Association with various demographic factors in women would help in categorising those women who are...

ea0095oc4.2 | Oral Communications 4 | BSPED2023

A deletion at 20p11.21 region involving FOXA2 causing Congenital Hyperinsulinism and extra pancreatic features

Hawton Katherine , Nath Stuart , Kumar Yadlapalli , Giri Dinesh

Introduction: Congenital hyperinsulinism (CHI) is a rare disease characterized by an unregulated insulin release, leading to hypoglycaemia. It is the most frequent cause of persistent and severe hypoglycaemia in the neonatal period and early childhood. FOXA2, a beta-cell transcription factor is localized at the cytogenetic location 20p11.2 and is critical for the development of pancreas and pituitary gland. We describe a child with 20p11.21 deletion e...

ea0099ep331 | Calcium and Bone | ECE2024

Denosumab therapy in diffuse sclerosing osteomyelitis – a case report

Vahidi Rad Mona , Ahmed Samir , Whitaker Michael , Kumar Aditi

Introduction: Diffuse sclerosing osteomyelitis (DSO) of the jaw is a chronic and rare condition that can present with recurrent and severe jaw pain and mandibular swelling. The treatment of this condition can often be quite challenging. We present a patient with mandibular DSO who had significant improvement in jaw pain with denosumab injections. Clinical Case: A 23-year-old female presented with left mandible pain for 4 years. Her symptoms started after...

ea0101ps1-07-05 | Case reports | ETA2024

Thyroid diagnostic dilemmas

Kumar Jesse , Hyer Steve , Laji Ken , Subbiah Kasi

We present the case of a 22-year-old male patient who posed a diagnostic dilemma due to discrepancies between his symptoms and biochemical markers in contrast to imaging findings. He reported a 18 month history of on and off neck swelling with associated symptoms of anxiety, tremor, loose stools and dry eyes (no weight loss). Thyroid function tests were normal with a Free T4 (FT4) of 12.4 pmol/l (12-22 pmol/l), TSH 2.75mU/l (0.27-4.2mU/l) and an ultrasound showed an enlarged a...

ea0102143 | Adrenals and Neuroendocrine Tumors | EYES2024

Decoding allgrove syndrome: a clinical odyssey through diagnosis and management challenges

K Anupriya , Joy Neethu , Kumar Garg Mahendra , Shukla Ravindra

Introduction: Triple A syndrome is a rare multisystem autosomal recessive condition, with a classical triad of Alacrimia, achalasia, and adrenal insufficiency. We describe our patientÂ’s clinical and genetic profile, highlighting the often-missed diagnosis due to its staggered presentation.Case presentation: A 22-year-old male, with history of Adrenal insufficiency diagnosed at age 3 and maintained on Glucocorticoid replacement presented to our emerg...

ea0104p8 | Adrenal & Cardiovascular | SFEIES24

Multivessel spontaneous coronary artery dissection in a young woman using cabergoline

Byrne Rachel , O'Shea Linda , Shiels Paul , Kumar Rajesh

Introduction: Spontaneous coronary artery dissection (SCAD) is a unique clinical entity gaining rapid recognition as an important cause of acute coronary syndrome (ACS). Cabergoline induced SCAD is exceedingly rare. We present a unique case of a young woman with multivessel SCAD on a background of Cabergoline use. To date, limited literature is available on cabergoline induced SCAD and we describe the first ever reported case in our country.Case report: ...