Searchable abstracts of presentations at key conferences in endocrinology

ea0081p17 | Adrenal and Cardiovascular Endocrinology | ECE2022

Bilateral adrenal haemorrhages secondary to Rivaroxaban on a background of p-ANCA vasculitis

Farhan Malik Mohammad , Sivappriyan Siva , Kumar Jesse , Anandappa Samantha , Iqbal Maliha , Khalid Maha

Background: A 73-year-old female presented to the hospital with a 3-day history of right upper quadrant abdominal pain and episodes of vomiting. Her past medical history included insulin treated Type 2 diabetes diabetes, deep venous thrombosis for which she was on rivaroxaban, COPD, right leg angioplasty and previous p-ANCA vasculitis. She also had flank tenderness and was noted to be hypertensive with a blood pressure of 225/93mmHg. A CT scan of the abdomen identified a new 4...

ea0081p356 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Prevalence and awareness of complications in type 2 diabetes mellitus : a hospital based comparative cross-sectional study

Mainali Uttar Kumar , Kamat Laxmi Narayan , Khatri Sanjeep , Acharya Den Prasad

Introduction: Diabetes Mellitus appears to be globally pandemic and is drawing attention as a major public health concern. Chronic complications of this disease can lead to poor quality of life with significant financial burden to family and country as well. The current study aims to assess prevalence of such complications and its awareness in type 2 diabetes population.Methods: This descriptive cross-sectional study was conducted during one year period ...

ea0081p220 | Thyroid | ECE2022

Alpelisib-induced thyroiditis in a patient with metastatic breast carcinoma

Prem Kumar Anusha , Flynn Calvin , J Higgins Michaela , K Crowley Rachel , O'Shea Donal , Garrahy Aoife

Background: Alpelisib is a novel phosphotidylinositol 3-kinase (PI3K) inhibitor which, in combination with fulvestrant, has been shown to increase progression-free survival in patients with HR+/HER2-/PI3KCA mutated advanced breast cancer[1]. Hyperglycaemia, including alpelisib-induced diabetic ketoacidosis is a known adverse effect, along with rash, diarrhoea and stomatitis. No other associated endocrinopathy has been reported to date. Case presentation: We present th...

ea0081ep618 | Endocrine-Related Cancer | ECE2022

Pro-inflammatory biomarkers in Papillary thyroid cancer

Bangaraiahgari Ramesh , Panchangam RAmakanth Bhargav , Bangaraiahgari Rajesh , U Udaya Kumar , Mayilvaganan Sabaretnam

Introduction: Papillary thyroid carcinoma (PTC) is the most frequent endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was ...

ea0081ep1015 | Thyroid | ECE2022

What is the ideal approach for thyroidectomy in a given patient? Proposal of an algorithm

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Bangaraiahgari Rajesh , U Udaya Kumar , Mayilvaganan Sabaretnam

Introduction: Thyroidectomy can performed by open or wide array of endoscopic techniques. Lack of uniform consensus on specific indications for each technique leads to confusion on ideal thyroidectomy technique. In this context, we analysed our experience with specific emphasis on deducing an algorithm on ideal technique for a given patient. Material and methods: This is a retrospective study conducted at a tertiary care endocrine surgery department in S...

ea0081ep1204 | Late Breaking | ECE2022

Role and expression of miRNAs (miRNA 548e_5p, miRNA 873_5p, miRNA 378b) in fetal development and incidence of Preeclampsia in pregnancy

Bangaraiahgari Ramesh , Bangaraiahgari Rajesh , Panchangam Bhargav , U Udaya Kumar , V Vinaya , Rajkiran Banala

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

ea0050p316 | Obesity and Metabolism | SFEBES2017

Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPARγ and insulin resistance

Adaikalakoteswari Antonysunil , Vatish Manu , Alam Mohammad , Ott Sascha , Kumar Sudhesh , Saravanan Ponnusamy

Background: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance (IR) and gestational diabetes (GDM). However, it is not clear whether these are causally related.Objective: B12 is a key co-factor of the DNA methylation cycle (1-carbon metabolism). We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs (miRs) during adipocyte differentiation...

ea0050cc03 | Featured Clinical Cases | SFEBES2017

A novel variant in the androgen receptor gene causing familial mild androgen insensitivity syndrome

Iacovazzo Donato , Kumar Ajith , Abbs Stephen , Solomon Andrew , Korbonits Marta , Druce Maralyn

Introduction: Androgen insensitivity syndrome (AIS) is a heterogeneous condition. At the milder end of the clinical spectrum, patients with mild AIS (MAIS) are phenotypically male, and may present with infertility, either isolated or associated with gynaecomastia or signs of mild undervirilization. Most cases of complete and approximately 25% of partial AIS patients harbour mutations in the androgen receptor (AR) gene. Over 1,000 pathogenic variants have been describe...

ea0050p316 | Obesity and Metabolism | SFEBES2017

Low vitamin B12 in pregnancy is associated with adipose derived circulating miRNAs targeting PPARγ and insulin resistance

Adaikalakoteswari Antonysunil , Vatish Manu , Alam Mohammad , Ott Sascha , Kumar Sudhesh , Saravanan Ponnusamy

Background: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance (IR) and gestational diabetes (GDM). However, it is not clear whether these are causally related.Objective: B12 is a key co-factor of the DNA methylation cycle (1-carbon metabolism). We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs (miRs) during adipocyte differentiation...

ea0050cc03 | Featured Clinical Cases | SFEBES2017

A novel variant in the androgen receptor gene causing familial mild androgen insensitivity syndrome

Iacovazzo Donato , Kumar Ajith , Abbs Stephen , Solomon Andrew , Korbonits Marta , Druce Maralyn

Introduction: Androgen insensitivity syndrome (AIS) is a heterogeneous condition. At the milder end of the clinical spectrum, patients with mild AIS (MAIS) are phenotypically male, and may present with infertility, either isolated or associated with gynaecomastia or signs of mild undervirilization. Most cases of complete and approximately 25% of partial AIS patients harbour mutations in the androgen receptor (AR) gene. Over 1,000 pathogenic variants have been describe...