Searchable abstracts of presentations at key conferences in endocrinology

ea0086p295 | Thyroid | SFEBES2022

Radioactive Iodine treatment (RAI) for benign thyroid disease: ESHT outcomes

Mizanour Rahman Md , Ravelo Maria , Gupta Sheena , Salt Chris , Sathis Kumar P

Introduction: Following a National training programme for Endocrinologists to provide RAI treatment for benign thyroid disease, the ESHT NHS Trust started Radioactive iodine (RAI) treatment for benign thyroid disease a couple of years ago. Previously ESHT trust patients were referred to neighbouring trusts for RAI treatment.Data/Results: The data was collected over a 12-18 month period. A total of 34 patients received RAI treatment during this period; 28...

ea0090p343 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Prevalence of mutations in cublin-megalin receptor genes in Diabetis Mellitus: Subset analysis of an Indian NGS (Next Generation Sequencing) study

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Kumar N Udaya , Bangaraiahgari Rajesh , Mayilvaganan Sabaretnam , Bangaraiahgari Chakrapani

Background: Diabetes mellitus (DM) is the commonest endocrinopathy, Worldwide. Amongst the protean complex genetic variations, cubulin gene and megalin gene mutations in diabetes are important in dictating genotype-phenotypic correlations and natural clinical course of diabetes. The genetic studies in this area are especially very sparse from Indian sub-continent. In this context, we analyzed the prevalence of cubulin (CBN) and megalin (LRP2) gene mutations, as part of NGS (Ne...

ea0090p653 | Endocrine-related Cancer | ECE2023

Innate differences in the molecular signature of inferior and superior human parathyroid glands: potential implications for parathyroid adenoma

Agarwal Shipra , Kar Parmita , Boruah Monikongkhona , Saha Soma , Millo Tabin , Kumar Chitresh , Vuthaluru Seenu , Goswami Ravinder

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterised by hypercalcemia, skeletal fragility, and renal stones with majority (75%) of parathyroid tumours localized to the inferior parathyroid glands. The reasons for this natural bias are not known till date. A probable reason may be due to inherent differences in the molecular milieu of normal superior and inferior parathyroid glands. Such questions cannot be answered using superior and inferior parathy...

ea0090p765 | Thyroid | ECE2023

An Fifty Six Gene panel Next Generation Sequencing Study of Follicular differentiated Thyroid Cancer: An Indian Study

Bangaraiahgari Ramesh , Bhargav Panchangam Ramakanth , Mayilvaganan Sabaretnam , Bangaraiahgari Rajesh , Kumar N Udaya , Bangaraiahgari Chakrapani

Background: Follicular differentiated thyroid cancer (FDTC) is the most common endocrine cancer, globally. Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput genetic sequencing in short time. This analysis offers useful information on tumor biology. NGS Studies on follicular differentiated thyroid cancer are scanty from South East Asia. In this context, we set out study the pattern of a genetic panel wide somatic mutations in thyroid cancer.<p cl...

ea0065p102 | Bone and calcium | SFEBES2019

Parathyroidectomy outcomes for primary hyperparathyroidism over a 2 year period at East Sussex Hospitals Trust

Lewis-Morris Timothy , Chahal Sukhdeep , Phillips Jennifer , Kirkland Paul , Kumar Sathis

Introduction: An audit of outcomes and indications for parathyroidectomy was conducted from April 2016 to April 2018 for all patients had primary hyperparathyroidism at East Sussex Hospitals Trust.Methods: Clinical notes, pathology results and radiology results were accessed to compile the dataset. Indications for surgery were based on the National Institute of Health criteria for parathyroidectomy in hyperparathyroidism from 2013....

ea0065p202 | Metabolism and Obesity | SFEBES2019

Endoplasmic reticulum stress directly impacts mitochondrial function in human adipocytes

Jackisch Laura , Murphy Alice , Kumar Sudhesh , Randeva Harpal , Tripathi Gyanendra , McTernan Philip

Background: Dysfunctional endoplasmic reticula (ER) and mitochondria contribute to the pathogenesis of obesity and type 2 diabetes mellitus (T2DM). This may, in part, be facilitated by cross-talk between the two organelles during conditions of nutrient excess such as obesity, however the potential impact of ER stress on mitochondrial function has not been well studied. This study investigated whether induction of ER stress in human adipocytes may contribute to mitochondrial dy...

ea0065p273 | Neuroendocrinology | SFEBES2019

Tissue responsiveness to cortisol: a novel clinical biosignature for the prediction of Nelson’s syndrome

Das Liza , Walia Rama , Bhansali Anil , Dutta Pinaki , Mukherjee Kanchan Kumar

Introduction: Nelson’s syndrome is a significant long-term complication of bilateral adrenalectomy for Cushing’s disease. However, evidence about possible factors that can predict its occurrence, is controversial and limited.Objective: The objective of this analysis was to elucidate the role of various factors in prediction of Nelson’s syndrome and the extent of their modifying effect.Methods: All patients with Cushi...

ea0063p430 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Efficacy of DHEA in improving Quality of Life in prolonged HPA axis suppression from exogenous steroids

Anandappa Samantha , Kumar Rakshit , Breen Louise , Thakali Sonu , Tam Maria , Magtoto Cynthia , Carroll Paul , Velusamy Anand

Dehydroepiandrosterone (DHEA) has been a subject of controversy for more than a decade being called ‘a miracle hormone’, the ‘elixir of life’ and ‘an anti-aging supplement’. However, recent literature has proven mild to moderate benefit in selected group of patients. Data is mostly limited to primary adrenal failure patients with adequate glucocorticoid and mineralocorticoid replacement and in hypopituitarism from variable aetiology associated wit...

ea0049ep134 | Clinical case reports - Pituitary/Adrenal | ECE2017

Recurrent phaeochromocytoma – Iatrogenic

Anandappa Samantha , Navaratnam Jeya , Fish David , Conry Brendon , Perera Sithara , Kumar Jesse

Phaeochromocytoma is a common endocrinological diagnosis with an incidence of 1–2 per 10 000 people. Prompt evaluation and treatment leads to an excellent prognosis. Recurrence has been documented rarely (with literature reporting possibility of up to 8 years delay) and causes are generally attributed to inherited mutations, seeding during surgery or malignancy. Malignancy rates have been variable from 10% depending on site and mutations. In addition, the definition of ma...

ea0049ep343 | Developmental endocrinology | ECE2017

Adolescent onset distal renal tubular acidosis presenting with significant growth retardation without rickets

Roy Sagarjyoti , Banik Sandipan , Maisnam Indira , Ray Aniruddha , Mukherjee Apurba Kumar

Introduction: Distal renal tubular acidosis (RTA) can have varied presentation. Onset in infancy is usually severe. However, adolescent onset has variable presentation ranging from hypokalemia to nephrocalcinosis, and rarely with rickets or growth retardation. We describe a girl with distal RTA presenting with hypokalemia and growth retardation.Case: 12 year old girl presented with recurrent episodes of weakness of all four limbs and failure to gain heig...