Searchable abstracts of presentations at key conferences in endocrinology

ea0077p31 | Bone and Calcium | SFEBES2021

Recombinant PTH 1-84 (Natpar) treatment in a case of refractory hypocalcaemia secondary to surgical hypoparathyroidism and malabsorption post-gastric bypass

Sagar Rebecca , Cooke Heather , Maguire Deidre , Abbas Afroze

We report the case of a 63-year-old lady with refractory hypocalcaemia due to surgical hypoparathyroidism, decompensated by malabsorption following gastric bypass, successfully treated with recombinant human parathyroid hormone 1-84 (rhPTH), Natpar. She initially presented with medullary thyroid cancer aged 33 and was found to have MEN2A. She underwent thyroidectomy and developed post-surgical hypoparathyroidism. She was managed for over 20 years with alfacalcidol and oral cal...

ea0077lb60 | Late Breaking | SFEBES2021

Iodinated Contrast-induced Thyrotoxicosis

Haniff Haliza , Han Htwe Nang PoePoe , Zaidi Zulfiqar , Abbas Muhammad

Introduction: The common causes of thyrotoxicosis are Graves’ disease, toxic multinodular goitre and toxic adenoma which account for >90% of cases of this condition. Iodine-induced thyrotoxicosis (Jod-Basedow syndrome) is infrequently considered as a cause of thyrotoxicosis. This case describes a lesser known cause of iodinated contrast-induced thyrotoxicosis.Case Report: A 47 year old man with known alcoholic liver disease and recurrent pancrea...

ea0081p523 | Adrenal and Cardiovascular Endocrinology | ECE2022

A retrospective evaluation of the utility of overnight dexamethasone suppression tests in over 500 patients evaluated for hypercortisolism

Sagar Rebecca , Elsabbagh Mohamed , Gibbons Stephen , Abbas Afroze

Background: Overnight dexamethasone suppression tests (ONDST) are conducted to investigate patients with symptoms suggestive of cortisol hypersecretion or if an adrenal incidentaloma is identified. Cortisol levels of 50 nmol/l and above following ONDST may be related to autonomous cortisol secretion (ACS) and require further investigation. Determining likely presence of ACS is essential given reported associations with type 2 diabetes mellitus (T2DM), obesity, cardiovascular d...

ea0086p6 | Adrenal and Cardiovascular | SFEBES2022

Evaluation of fracture risk in patients with mild autonomous cortisol secretion and adrenal incidentaloma

Eyadeh Ahmad , Sagar Rebecca , Htwe Nang , Abbas Afroze

Background: Patients with adrenal incidentaloma (AI) and cortisol levels of 50-138 nmol/l on overnight dexamethasone suppression tests (ONDST) may have “mild autonomous cortisol secretion” (MACS). MACS is associated with increased morbidity, including osteoporosis, but this is infrequently systematically evaluated. We compared fracture risk and fracture prevalence in patients with AI, both with and without MACS.Methods: Data were collected retr...

ea0090p561 | Adrenal and Cardiovascular Endocrinology | ECE2023

UK Lung cancer screening guidelines; are functional adrenal lesions being missed?

Sagar Rebecca , Scarsbrook Andrew , Callister Matthew , Abbas Afroze

Background: Adrenal incidentalomas are common and require investigation to exclude malignancy and evidence of hormone overproduction. Prospective screening programmes are essential for early detection of cancer but often lead to incidental findings which have potential health economic implications and may increase patient anxiety. With regards to investigation of incidental adrenal nodules, current national lung cancer screening recommendations are not in keeping with current ...

ea0049ep741 | Endocrine Disruptors | ECE2017

24 hrs chronomics of BP/HR in terms of double amplitude, acrophase, hyperbaric index and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift nursing professionals: A Case-control study

Anjum B , Verma Narsingh , Tiwari Sandeep , Singh Ranjana , Mahdi Abbas

The present study was aimed to investigate the 24 hours chronomics of BP/HR in terms of Double amplitude, Acrophase and Hyperbaric index and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift nurses and actual day workers. 56 night shift nurses, aged 20–40 years, performing day and night shift duties were recruited from the Trauma Center, KGMU, India, and 56 age sex matched actual day workers were also enrolled as controls. BP and HR were recorded ...

ea0041ep61 | Adrenal cortex (to include Cushing's) | ECE2016

Circadian rhythm of salivary cortisol & 6 – sulfatoxy melatonin in night shift nursing professionals and actual day workers

Anjum B , Verma Narsingh , Tiwari Sandeep , Singh Ranjana , Mahdi Abbas

Objectives: The present aimed to investigate the circadian pattern of salivary cortisol & sulfatoxy melatonin level in night shift professionals and actual day workers & to find out these changes in the circadian pattern produce by night shift are reversible in due course of time.Methods: 56 Nursing professionals of both gender who perform day and night shifts and 56 actual controls were also recruited in this study. Saliva and urine samples were...

ea0059p039 | Bone and calcium | SFEBES2018

Management of hypoparathyroidism against European guidelines: Experience of a large teaching hospital

Jamal Jameel , Scholes Amelia , Sagar Rebecca , Abbas Afroze

Background: Hypoparathyroidism is a rare endocrine disorder characterised by low serum calcium with inappropriately low parathyroid hormone (PTH) levels. Calcium and vitamin D analogues have traditionally been the mainstay of treatment. However, these treatments may cause complications and may not fully address the well-being of this patient group. This study evaluates the current management of hypoparathyroidism in a large UK teaching hospital compared against current Europea...

ea0059p040 | Bone and calcium | SFEBES2018

Symptom documentation in patients with primary hyperparathyroidism before and after the introduction of a symptom scoring questionnaire

Hamer Lucy , Miller Elsha Madgwick , Sagar Rebecca , Abbas Afroze

Background: Symptoms consistent with hypercalcaemia are an indication for surgery in patients with primary hyperparathyroidism (PHPT). However, symptoms can be subtle and may not be documented systematically. We analysed the documentation of symptoms in a large series of patients with PHPT, and the subsequent impact of introducing a symptom scoring questionnaire.Methods: A standardised proforma was used to retrospectively analyse symptom documentation by...

ea0038p227 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Circadian rhythm of ambulatory blood pressure in rotating night shift nursing professionals and its relation with 6- sulfatoxy melatonin as neuroendocrine chronomolecule

Anjum B , Verma Narsingh , Tiwari Sandeep , Singh Ranjana , Mahdi Abbas

Background & aim: Night shift work is associated with a disruption of circadian rhythms, where a person’s internal body clock is in conflict with the rotating shift schedule. The circadian rhythm of the human body is characterized with an alternating sleep-wake cycle. Shift work has been associated with increased risk of hypertension, cardiovascular diseases and hormonal disturbances. The Present study was aimed to investigate the effects of rotating night shift on 24...