Endocrine Abstracts

Aim: To measure Urocortin3 (Ucn3) blood levels in morbidly obese (MO) non diabetic patients before and after laparoscopic sleeve gastrectomy (LSG) for excess body weight reduction and explore its relationship with b-cell function. Ucn3 is involved in insulin secretion in the presence of nutrient excess, a key feature of obesity, and may be an integral part of the compensation of β-cells function.Methods: Nine MO patients who underwent LSG and 11 hea...

Introduction: A high prevalence of sexual disorders has been observed in women with types 1 and 2 diabetes mellitus (DM). Here we present 4 years, two-center results of the study of disorders of female sexual functioning in female patients with diabetes.Materials and methods: During the time period 2011–2014, female DM patients and healthy controls were enrolled according to the protocol inclusion criteria. The FSFI, FSDS, and GHQ-28 questionnaires ...

Graves’ orbitopathy (GO) is an auto-immune disorder that targets intra-orbital tissues. It is well proven to involve inflammatory hypertrophy of the rectus EOMs. Superior oblique (SO) muscle has been sporadically reported to be involved in GO. However, there are extremely few reports in the literature that refer to the involvement of the inferior oblique (IO) muscle and here we present such a case.A 33-year-old man with unilateral exophthalmos was r...

Background: Clinical evaluation of Graves’ orbitopathy (GO) is often insufficient. Frequently it is difficult to decide whether a case of GO is active, or to detect the degree of severity. STIR sequence MRI suppresses signal from fat and thus in the orbits can also detect active inflammation and oedema of extra-ocular muscles (EOMs). The aim of the present study is to examine whether imaging of rectus EOMs with STIR MRI could provide additional information for the activit...

Introduction: Data on Vitamin B12 deficiency and its relationship with Gestational Diabetes Mellitus (GDM) andpregnancy outcomes are limited. The aim of the present study is to determine, in pregnant women with GDM, the association between Vitamin B12 levels and glycemic control, as well as with pregnancy outcomes.Methods: We studied 44 women with GDM, mean age 31.9 ± 5.8 years old, at the second trimester and at labor and measured weight, height, b...

Introduction: Limited data, support the notion that testosterone induces oxidative stress. Corticotropin-releasing hormone (CRH) participates locally in the endothelial inflammatory response by regulating the pro-oxidative mechanisms of the endothelium, inducing its adaptation to local stress. The present study was undertaken to determine whether the CRH induced pro-oxidant activity in macroendothelial cells under basal conditions, is regulated In vitro by androgen (t...

Introduction: Limited data exist on testosterone and oxidative stress induction. The present study was undertaken to evaluate, in vitro, the role of physiological concentrations of androgens (testosterone-DHT) in modulating the pro-oxidant and antioxidant activity of intact endothelial cells.Materials and methods: EA.hy926 macroendothelial cells were cultured in DMEM phenol red free without FBS for 24 hours. Growth medium was replaced and then testostero...

Introduction: Postmenopausal virilization with acute onset and rapid progression requires a thorough investigation for the presence of adrenal or ovarian tumor. We present here a challenging case of a radiologically not visible and rare androgen-hypersecreting ovarian tumor.Case report: A 71-year old postmenopausal woman presented to our department for the investigation of terminal hair growth, of recent onset and rapid progression, on the upper lip, chi...

Introduction: 17- α hydroxylase deficiency, an autosomal recessive disorder, is a rare cause of Congenital Adrenal Hyperplasia (CAH). The disease is usally diagnosed during infancy and childhood. We present here a rare case of an adult woman with 17-α hydroxylase deficiency diagnosed for first time in adulthood.Presentation: A 49 year old woman, with no previous medical history came to the emergency department of our hospital unconscious with G...

Introduction: Infectious diseases of the central nervous system (CNS) have been associated with hypopituitarism which relates to the severity, the localization and the cause of the infection. We present here a case of a CNS abscess and hormone deficiencies. A 53 years old man referred to the emergency department of our hospital with high fever and confusion and a 3 day history of weakness and anorexia. On clinical examination he was febrile (38.4oC), disoriented in ...