Searchable abstracts of presentations at key conferences in endocrinology

ea0086p215 | Metabolism, Obesity and Diabetes | SFEBES2022

Metabolic syndrome and obesity in IBD patients: how common?

Soare Iulia , Sirbu Anca , Diculescu Mircea , Radu Mateescu Bogdan , George Tieranu Cristian , Martin Sorina , Fica Simona

Introduction: Although patients with inflammatory bowel disease (IBD) -Crohn’s disease (CD) and ulcerative colitis (UC)- are considered prone to malnutrition, studies have shown an increased risk for obesity, especially visceral obesity and metabolic syndrome (MetS). Possible mechanisms involved include dysbiosis, gut microbiome and chronic inflammation. The aim of the study was to assess the prevalence of MetS and obesity in a group of IBD patients.<p class="abstext"...

ea0090ep66 | Adrenal and Cardiovascular Endocrinology | ECE2023

Overview and factors that impact quality of life in patients with Cushing’s syndrome

Nacu Miruna-Viorela , Martin Carmen Sorina , Sirbu Anca , Barbu Carmen , Fica Simona

Background: Quality of life (QoL) has become a useful outcome in recent studies among different specialties. In Cushing’s syndrome, elevated cortisol levels result in a decreased QoL, the cause for this impairment being multifactorial. More studies are necessary to find modifiable factors where doctors could intervene and thus improve QoL.Objective: To evaluate QoL in a group of Romanian patients with Cushing’s syndrome. Design: We performed a ...

ea0090ep128 | Calcium and Bone | ECE2023

Height loss is almost 5 times more correlated with trabecular bone score than with bone mineral density. Study on over 900 patients (2023)

Peretianu Dan , Sirbu Adrian , Motoiu Serban , Gavrila Catalin , Stanciu Mihaela , Ranetti Aurelian E

Aim: To show that height loss is more correlated with vetebral micoarchitecture than with Bone Mineral Density (BMD). Material and Method: A. DEXA: made with a GE-Lunar Prodigy Pro # 500074. Vertebral microarchitecture was investigated by Trabecular Bone Score (TBS). TBS software: TBS iNsight®, version 3.0.2.0.B. Patients. 902 patients, 844 (93.6%) women, 58 men. Only 42 under 50 years. Age av...

ea0065p82 | Bone and calcium | SFEBES2019

Association between lean mass and bone mass density in patients with inflammatory bowel disease

Soare Iulia , Sirbu Anca , Mateescu Bogdan Radu , Martin Sorina , Tieranu Cristian , Diculescu Mircea , Fica Simona

Introduction: Patients with inflammatory bowel disease (IBD) are at increased risk for decreased bone mass density (BMD), fractures. Preserved muscle mass is important for healthy bones. Low mean mass can be found in these patients due to immobilization, lack of physical activity and glucocorticoids. Our aim was to evaluate the presence of low BMD and muscle mass impact on it.Methods: 64 patients with inflammatory bowel disease (40 with Crohn disease, 24...

ea0065p168 | Metabolism and Obesity | SFEBES2019

Long term impact of sleeve gastrectomy on metabolic parameters in morbidly obese patients

Sirbu Anca , Soare Iulia , Martin Sorina , Popa Miruna , Barbu Carmen , Copaescu Catalin , Fica Simona

Background: A large body of evidences have demonstrated that metabolic surgery is associated with significant and durable weight loss as well as a significant improvement of obesity-related comorbidities. The aim of our study was to evaluate the long term impact of gastric sleeve on metabolic parameters in morbidly obese patients.Materials and methods: We evaluated 95 (67 women) severely obese patients (mean age 43.4±10.69 years) before and approxim...

ea0063p478 | Calcium and Bone 2 | ECE2019

Trabecular bone score - a more sensible indicator in predicting negative change than bone mass density?

Soare Iulia Simona , Sirbu Anca Elena , Mateescu Bogdan Radu , Cima Luminita Nicoleta , Fica Simona

Background: Glucocorticoid-induced osteoporosis is common in chronic diseases as inflammatory bowel disease. Although BMD (bone mass density) is used for the estimation of the quantity of the bone, on the contrary, TBS (trabecular bone score) is a new parameter, a gray-level textural assessment of bone microarchitecture, providing estimation of quality of bone. Several studies showed increased level of TBS during teriparatide treatment in glucocorticoid induced osteoporosis.</...

ea0063p479 | Calcium and Bone 2 | ECE2019

Relationship between serum levels of 25-OH vitamin D and parameters of bone mineralization (BMD) and bone quality (TBS) in clinical practice

Sirbu Anca , Popa Miruna , Martin Sorina , Albu Alice , Barbu Carmen , Sava ELisabeta , Fica Simona

Introduction: Vitamin D is a hormone essential for calcium absorption and bone mineralization, which is positively associated with bone mineral density. The aim of our study was to evaluate the relationship between 25-OH vitamin D values and parameters of bone mineralization (bone mineral density - BMD) and bone quality (trabecular bone score - TBS) in patients from day to day clinical practice.Materials and methods: We evaluated 433 postmenopausal women...

ea0063p831 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Catecholamine-secreting tumor and pancreatic tumor fibrosis – a coincidence?

Pascu Raluca Cristina , Popa Miruna Maria , Sirbu Anca Elena , Fica Simona

Introduction: Cells of the neuroendocrine system are spread throughout the body, and they can give rise to various neuroendocrine tumors with unpredictable evolution. It has been observed that they are often associated with the development of fibrosis, both local and distant.Case presentation: We present the case of an 81 year-old, normal-weight woman, who firstly presented in our clinic in 2014 for multinodular goiter (normal calcitonin). Fine needle as...

ea0063p845 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Iatrogenic Cushing syndrome due to use of intranasal betamethasone – two case reports

Popa Miruna Maria , Pascu Raluca Cristina , Poterasu Mihaela , Sirbu Anca Elena , Fica Simona

Background: Iatrogeny is the most common cause of Cushing syndrome (CS), with most reported cases due to prolonged use of oral, parenteral or, rarely, topical corticosteroid preparations. Few cases of CS (and consecutive adrenal insufficiency (AI)) due to intranasal corticoids have been reported and the vast majority were documented in pediatric patients.Case reports: We present two cases of iatrogenic CS due to chronic intranasal administration of over-...

ea0063p1186 | Thyroid 3 | ECE2019

Graves’ disease in asssociation with common neoplasms – a retrospective study

Nistor Irina , Martin Sorina , Sirbu Anca , Albu Alice , Barbu Carmen , Fica Simona

Introduction: Graves’ disease is an autoimmune disease that leads to a generalized overactivity of the entire thyroid gland – hyperthyroidism. Although the link between Graves’ disease and thyroid carcinoma was widely explored, we cannot undermine the relationship between this condition and other common neoplasms.Materials and method: The retrospective analysis was performed using clinical data of 295 adult patients (225 women and 70 men) ...