Endocrine Abstracts

Introduction: Woodhouse-Sakati Syndrome (WSS) is a very rare autossomic recessive disorder caused by mutations in DCAF17 gene that primarily affects the endocrine and the nervous systems. It is associated with hypogonadism, diabetes mellitus, hypothyroidism, sensorineural hearing loss, alopecia and extrapyramidal findings. Treatment is symptomatic and managed by multidisciplinary teams. Less than 80 cases are reported to date.Case repor...

Introduction: Insulinomas are the most frequent cause of endogenous hypoglycaemia. 90 to 95% of these are benign. Surgical enucleation or resection is the standard treatment. Medical therapy focuses mainly on the use of diazoxide with few alternatives in patients with high surgical risk.Case-report: Female patient, 89 years-old, non-diabetic, with previous history of acute myocardial infarction, stroke with motor sequelae, pacemaker carrier and severe ao...

Introduction: Evidence implicates oxidative stress as mediator of diabetic complications. Furthermore, glucose variability (GV) is associated with oxidative stress and inflammation; however, association between GV and diabetes complications remains to be established. Our aim was to assess GV in patients with and without microvascular complications (MVC).Methods: We analysed 2454 and 6593 h of continuous glucose monitoring of patients with type 1 diabetes...

Introduction: Radioiodine (131I, RAI) is a safe and effective option for the treatment of Graves’ disease (GD). However, approximately 20% of RAI treated patients will have persistent disease or will relapse after the first treatment. Our aim was to identify the factors influencing the outcomes in RAI treatment for GD.Methods: We analysed 143 DG patients (116 women) treated with RAI between October 2002 and April 2014 and ≥12 months...

Introduction: Primary hyperaldosteronism (HAP) is the main cause of secondary hypertension, with a prevalence estimated between 6 and 20% in resistant hypertension. Clinical suspicion is critical, especially if aldosterone-to-renin ratio (ARR) >25, however the diagnosis is dependent on confirmatory evidence, including aldosterone suppression tests.Methods: Retrospective evaluation of 44 patients with suspected PAH, identified betwee...

Introduction: Despite being a psychiatric disorder, anorexia nervosa (AN) is associated to severe systemic complications. The endocrine complications of AN are an opportunity for the diagnosis and treatment of this condition. The authors report the experience of the Endocrinology Department in the treatment of AN in inpatient setting.Patients and methods: Retrospective analysis of 45 patients admitted with AN between 2001 and 2015 in the Endocrinology de...

Introduction: Hypophostemic rickets is characterized by phosphate renal loss associated with a primary defect of osteoblasts and metabolism of vitamin D. Marked bone turnover caused by high levels of parathyroid hormone attribute to these patients an elevated risk for hungry bone syndrome after parathyroidectomy.Case report: A 34-years old woman with a past history of Lynch syndrome and hypophostemic rickets associated with hyperparathyroidism and brown ...

Introduction: Glutamic acid decarboxylase (GAD65) is expressed by pancreatic beta cells and also by GABA (gamma-aminobutyric acid)-secreting neurons. Cerebellar ataxia associated with anti-GAD65 antibodies (antiGAD Ab) is a rare neurological disorder that frequently coexists with other autoimmune conditions, namely Diabetes Mellitus (DM).Case reports: We describe two cases of ataxia associated with antiGAD Ab. The first case is a 69-year-old obe...

Introduction: The diagnosis of infected ulcer is mainly clinical. The goals of the microbiological studies are identification of the pathogen and evaluation of susceptibility to antibiotics to minimize exposure to drugs and selection of resistant strains.Methods: Retrospective cohort study; Data collection: 1 January 2010 to 31 December 2014. Were included wound samples of aspirate, nonsurgical/surgical exudate, pus from abscesses and bone fragments from...

Introduction: The complications related to ulcerated foot lesions are a common cause of hospitalization among diabetics. Diabetic foot infection is associated with high morbidity and is the most common precipitating factor to precede amputations of the lower limbs.Methods: Retrospective, cohort study; were included 200 patients from the Diabetic Foot consultation of the Endocrinology Department between 1 January and 31 August 2015. Ulcerated lesions were...