Endocrine Abstracts

Introduction: Low vitamin D status has been associated to COVID-19 risk, and type 2 diabetic patients are a vulnerable group. Even though the Canarian archipelago is one of the sunniest spots in Europe, our prevalence of vitamin D deficit is known to be very high. The mandatory lockdown may have worsened this deficit, increasing the need for vitamin D supplementation.Objectives: Our main objective was to assess and compare the prevalence of vitamin D def...

Introduction: Classically, hypertension (sustained or paroxysmal) is described in > 98% of diagnosed pheochromocytomas. Nowadays the systematic workup of adrenal incidentalomas has made uncovering normotensive pheochromocytomas no longer exceptional. However, normotensive pheochromocytomas have a catecholamine secretion characteristically lower than hypertensive pheochromocytomas. It must be emphasized that the perioperative hemodynamic instability is comparable in hyperte...

Introduction: Even though most hypertensive patients have essential hypertension, in the resistant cases the prevalence of secondary hypertension is much higher; therefore its screening should be mandatory. Resistant hypertension usually causes a progressive decline of renal function if blood pressure is not adequately controlled. Such decline is often irreversible; however a timely diagnosis leading to a resolutive treatment can alleviate or even revert the progression of the...

Objectives: Understanding and propagating the knowledge of the burden caused by the massive infradiagnosis of Primary Aldosteronism (PA), partly due to unawareness of its high prevalence and partly to the complexity of its screening in Primary Care and workup in Specialized Care.Methods: Review of the relevant literature and personal reflections.Results: PA is the first cause of secondary hypertension and a highly prevalent disease...

Introduction: Insulin is not an optimal treatment in obese type 2 diabetic patients with insulin resistance. We often introduce it as a last resort hoping to improve the metabolic control of our patients. However it is not always effective, and tends to increase body weight, worsen the global cardiovascular risk and cause hypoglycemias. New drugs such as the GLP-1 agonist receptors can be a better alternative and sometimes allow withdrawal of insulin.Cli...

IntroductionAnorexia nervosa is a severe and potentially lethal eating disorder. We report hereby the cases of two female-to-male transsexual patients whose anorexia nervosa was promptly resolved when they started gender-affirming hormone therapy.MethodsReview of the patients’ clinical records and of the relevant literature.Case reportsA 15 year-old male tran...

IntroductionCarney Complex is a rare syndrome characterized by lentiginosis cutis and/or blue nevi, multiple endocrine neoplasia and non-endocrine tumors (cutaneous, mucosal, mammary or cardiac myxomata, bone osteochondromyxoma, psammomatous melanotic schwannoma, multiple ovarian cysts, multiple mammary ductal adenoma). Most cases are familiar, with autosomal dominant heredity and penetrance close to 100%. It is caused by a variety of mutations that acti...

IntroductionMany transsexual patients are concerned about the risk of cancer associated with hormonal gender-affirming therapy. However, the general risk seems to be very low. We hereby report the case of a strikingly large gastrointestinal stromal tumor (GIST) in a male-to-female transsexual patient, after 25 years of hormonal therapy.MethodsReview of the patient’s clinical records and the relevant lite...

IntroductionVitamin D deficiency is associated with higher risk of COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (81.0% < 30 ng/ml plasma calcifediol) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown in Northern Gran Canaria. During the winter period (December 2020 to February 2021) some restrictions for social gatherings and a nightly curfew have been en...

IntroductionSevere hemorrhage is a rare and potentially lethal manifestation of adrenal gland nor usually associated with primary aldosteronism.Material and methodsReview of the patient’s clinical record and of the relevant literature.Case reportA 47-year-old male with personal history of asthma, untreated stage II hypertension, obesity, dysphagia associated ...