Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1240 | Obesity | ICEECE2012

Comparing effects of lifestyle modification-induced weight loss on androgen levels, endothelial, sexual and urinary function, and quality of life in obese men with and without androgen deficiency

Khoo J. , Chen R. , Cho L. , Tan E. , Tay T. , Au V. , Soh S. , Ng B.

Introduction: Androgen deficiency (AD) is associated with endothelial and erectile dysfunction, lower urinary tract symptoms (LUTS) and reduced quality of life (QoL) in obesity. We aimed to compare effects of weight loss induced by lifestyle modification on endothelial and erectile function, LUTS and QoL in obese men with and without AD.Methods: abdominally obese Asian (body mass index≥30 kg/m2, waist circumference [WC] ≧ 90 cm) m...

ea0025p281 | Reproduction | SFEBES2011

HRPE773 (ZG16B) expression is elevated in human endometrium during the early secretory phase of the menstrual cycle and in uterine decidua following miscarriage

Ng Bonnie , McDonald Sarah , Ren Xia , Mullins John , Rae Michael , Critchley Hillary , Horne Andrew , Morley Steven

Introduction: Expression of murine CSP-1/Dcpp secretory proteins was first identified in sublingual salivary glands and subsequently in secretory epithelia of several other tissues, including the mouse female reproductive tract where expression is regulated by oestrogen. Preliminary studies indicated that HRPE773, the human CSP-1/Dcpp orthologue, displayed a similar pattern of expression to its murine counterparts. We therefore hypothesized that HRPE773 might be expressed in h...

ea0021p58 | Clinical practice/governance and case reports | SFEBES2009

Audit on the safety of the insulin stress tests in a tertiary endocrine referral centre

Ng Jen Min , Aye Myint , Ward Leanne , Narayanan Deepa , Atkin Stephen L , Kilpatrick Eric S

Background: The insulin stress test (IST) is accepted as the gold standard investigation of the hypothalamio-pituitary–adrenal axis (HPA). The test has been shown to be reliable though potentially unpleasant for the patient and has been associated with complications such as loss of consciousness, seizures, arrythmias, angina, myocardial infarction and death. To this effect close medical supervision is always required when an IST is performed.Methods...

ea0019p356 | Thyroid | SFEBES2009

Levothyroxine and iron in pregnancy: right dose, wrong time?

Ng JM , Wakil A , Dawson A , Masson EA , Allan BJ , Lindow SW , Krishnan R , Wardell S , Igzeer Y

Background: Absorption of levothyroxine is significantly reduced in the presence of oral iron if these two medications are ingested simultaneously, possible as a result of the formation of an insoluble complex with these 2 medications. Ideally all hypothyroid pregnant women on thyroid replacement therapy should be advised to avoid simultaneous ingestion of levothyroxine and iron containing medicines.Patients and methods: We conducted a retrospective obse...

ea0019p358 | Thyroid | SFEBES2009

Thyroxine dose adjustment during pregnancy

Dawson A , Ng JM , Wakil A , Krishnan R , Igzeer Y , Masson EA , Allan BA , Lindow S W

Background: Thyroid hormone is essential in foetal neurological development and thyroid hormone deficiency in pregnant women has been linked to lower intelligence quotient and underperformance in their children later in life. Thyroid hormone requirement increases during pregnancy by approximately 50% in the first trimester. We audited our practice of increasing thyroid hormone dose at booking and thereafter in pregnant women attending our combined obstetric medical clinic....

ea0019p369 | Thyroid | SFEBES2009

Epitopes for calcium-sensing receptor antibodies in patients with autoimmune polyendocrine syndrome type 1 are located in the N-terminal of the extracellular domain

Kemp EH , Gavalas NG , Akhtar S , Krohn KJE , Brown EM , Watson P , Weetman AP

Context: Autoimmune polyendocrine syndrome type 1 (APS1) is an autosomal recessive disorder caused by mutations in the autoimmune regulator gene. Hypoparathyroidism occurs in 80% of patients with APS1 and has been suggested to result from an autoimmune reaction against the calcium-sensing receptor (CaSR) on parathyroid cells. Previously, we have detected CaSR-binding antibodies in patients with APS1 using immunoprecipitation and flow cytometry assays.Obj...

ea0014p197 | (1) | ECE2007

Neonatal sex steroid exposure of female rats results in insulin resistance and enlarged mesenteric adipocytes

Alexanderson Camilla , Lystig Theodore , Stener-Victorin Elisabeth , Lönn Malin , Holmäng Agneta

Introduction: Neonatal events may contribute to the development of disorders such as type 2 diabetes and obesity at adult age. We have previously shown that neonatal testosterone (T) programming of female rats is followed by insulin resistance and changes in adipose tissue distribution with centralization of body fat. Therefore, the aim of this study was to examine the effects of neonatal injection of T, estradiol (E) or dihydrotestosterone (DHT) on insulin sensitivity and siz...

ea0011p393 | Diabetes, metabolism and cardiovascular | ECE2006

Functional analysis of cardiac orexin receptors: preferential activation by OR-B

Chen J , Karteris E , Rodrigo G , Stanfield P , Ng A , Randeva HS

The family of G-protein coupled receptors (GPCRs) are amongst the best-described regulators of cardiovascular pathophysiology. In rodents, intracerebroventricular administration of orexins increases mean arterial pressure and heart rate. However, important peripheral actions of orexins and their cognate receptors is now increasingly of interest.In this study we demonstrated that both receptors are present across the rat heart, at mRNA and protein level. ...

ea0007p259 | Clinical case reports | BES2004

Diagnostic difficulty in differentiating between meningioma and pituitary adenoma

Hatfield E , Lewis D , Powell M , Ng K , Kong C , Johnston C

We report two patients (AB 41 years, LS 55 years) presenting with symptoms of hyperprolactinaemia. Prolactin levels were moderately elevated: 1539 (AB), 1186 (LS) (NR 59-619 mU/L). The remainder of the pituitary profile was normal. Neither patient had visual field defects. MRIs (without contrast) reported pituitary macroadenoma with suprasellar extension but no optic chiasm compression. The initial diagnosis was of probable non-functioning adenoma causing stalk compression. Bo...

ea0056p378 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

Description of clinical, biochemical and radiological variability of Hepatocyte Nuclear Factor-1βeta (HNF1β) Mutations

Zamuner Matilde Bettina Mijares , Ng Nicholas Khay Jin , Siddique Nadia , Burke Marie , Byrne Maria

Background: HNF1β mutations are one of the commonly identified genetic causes of renal malformations, but one of the less common forms of MODY. HNF1β is involved in the development of kidneys, liver, pancreas, intestine and urogenital tract. Patients can present with distinctive but highly variable clinical features. The aim of this study is to evaluate the clinical, biochemical and radiological variability of HNF1β variants and the challenge of management on th...