Searchable abstracts of presentations at key conferences in endocrinology

ea0073pep7.4 | Presented ePosters 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Predictors of glucagon-like peptide-1 responses following oral glucose tolerance test in 3 ethnic groups of Malaysia

Chong Shiau Chin , Sukor Norlela , Robert Sarah Anne , Ng Kim Fong , Azmi Kamaruddin Nor

IntroductionGlucagon-like peptide-1 (GLP-1) plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, results from previous studies on the GLP-1 secretory responses in individuals with different glucose tolerance states remain controversial. This may be contributed by the heterogeneous characteristics of the patients recruited.AimTo examine whether GLP-1 secretion is affected...

ea0073aep820 | Late Breaking | ECE2021

Ethnicity and its influence on post-oral glucose tolerance test glucagon-like peptide-1 responses

Chin Chong Shiau , Sukor Norlela , Anne Robert Sarah , Fong Ng Kim , Azmi Kamaruddin Nor

IntroductionGlucagon-like peptide-1 (GLP-1) plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). Results from some studies on post-OGTT GLP-1 responses involving East Asians with abnormal glucose tolerance states tend to differ from the West. This may be attributed to the different diabetic phenotypes found in East Asians.AimTo examine post-OGTT GLP-1 responses in subjects with n...

ea0095p40 | Gonadal, DSD and Reproduction 1 | BSPED2023

Systematic review and meta-analysis of spermatogenesis rates after pubertal induction with gonadotropins in males with hypogonadotropic hypogonadism

Alexander Emma , Yin Kyla Ng , Faruqi Duaa , Farquhar Robert , Unadkat Ayesha , Varughese Rachel , Howard Sasha

Background: Hypogonadotropic hypogonadism is characterised by inadequate secretion of gonadotropins (luteinising hormone (LH) and follicle-stimulating hormone (FSH)) leading to absent, partial or arrested puberty. In males, classical treatment with testosterone promotes virilisation but does not facilitate testicular growth or spermatogenesis. Conversely, treatment with gonadotropins stimulates Sertoli and Leydig cells directly, leading to increased testicular...

ea00100wh2.4 | Workshop H: Miscellaneous endocrine and metabolic disorders | SFEEU2024

Mind your PJPs and coombs

Ng Elisabeth , Goodchild Emily , Pittaway James , Gaoatswe Gadintshware , Hussain Shazia , Drake William

A previously fit and well 29-year-old male presented with an 8-month history of progressive facial and peripheral swelling, accompanied by generalised weakness, weight gain, nocturia and a 2 year history of left-sided abdominal pain. He was originally from Ghana and moved to the UK in 2022 with limited family support. On examination he was hypertensive (157/108 mmHg) with facial fullness, dry skin, proximal muscle weakness, conjunctival injection and haematomata at recent vene...

ea0103oc10.4 | Endocrine Oral Communications 4 | BSPED2024

Education of sick day management of paediatric adrenal insufficiency: a national survey of paediatric endocrine nurse specialists

Bradford Anna , McKechnie Jennifer , AbdelRahman Shima , Mushtaq Talat , Ng SM , Tollerfield Sally , Laing Peter , Wong SC

Background and aims: A critical component of adrenal insufficiency (AI) management is education for the family and young person regarding sick day episode management. Deficits in patient education have been identified to contribute to adrenal crisis risk. The aim of this online survey distributed via the British Society for Paediatric Endocrinology (BSPED) paediatric endocrine nurse specialists (PENS) mailing list is to identify current clinical practice regarding education in...

ea0103p15 | Diabetes 1 | BSPED2024

Exploring perspectives of children and young people with type 1 diabetes in laos: moving beyond twice daily insulin to multiple daily regimens"

Ng Sze , Manivong Amphayvanh , Phommachack Daoheuang , Phimmasone Khounpaseuth , Khambuapha Khamtavanh , Nguyen Linh , Martin Tyla , Ooi Fiona

Background: In numerous low-income countries (LMICs) across Southeast Asia, the standard insulin therapy for people diagnosed with type 1 diabetes (T1D) is twice-daily premix insulin regimen. In Laos, the national health coverage fdoes not include provisions for insulin or blood glucose testing kits. Prior to 2016, no Laotian individuals were known to have survived with T1D. Intensive insulin therapy utilising a multiple daily insulin (MDI) regimen has now become the recommend...

ea0078p12 | Diabetes | BSPED2021

Government partnership working in Southeast Asia low-middle-income countries and Action4Diabetes improves Type 1 diabetes care

May Ng Sze , Iv Malene , Nilar Myint , Rassavong Khaysy , Vu Chi Dung , HS Tan Florence , Lek Ngee , Toomey Charles

Introduction: Globally, the main cause of mortality of type 1 diabetes (T1D) is lack insulin access. There is minimal data of health outcomes for T1D in low-middle-income countries (LMICs) in South-East Asia (SEA) where government funding of insulin and blood glucose monitoring kits either do not exist or is limited. Action4Diabetes (A4D) is a non-government organisation (NGO) initiated in 2016 and supports children and young people (CYP) with T1D in five countries -Laos, Mala...

ea0044p131 | Neoplasia, cancer and late effects | SFEBES2016

Metformin alters an anti-proliferative effect of Mitotane in a human adrenocortical cancer (H295R) cell line: preliminary results

Dworakowska Dorota , Szyszka Paulina , Weitsman Gregory , Diaz-Cano Salvador , Korbonits Marta , Grossman Ashley , Bornstein Stefan , Ng Tony

Introduction: Metformin is used as a first line treatment in type 2 diabetes. Several studies suggest that patients with type 2 diabetes treated with metformin may have reduced cancer risk. Recently it has been shown that Metformin acts directly on mitochondria to alter cellular bioenergetics and reduce tumorigenesis. We have shown that anti-proliferative effect of Mitotane is related with changes of expression of the genes involved in mitochondrial metabolism in human adrenoc...

ea0038p352 | Reproduction | SFEBES2015

I.v. and s.c. infusions of kisspeptin-54 stimulate gonadotrophin release similarly in healthy women

Narayanaswamy Shakunthala , Jayasena Channa , Ng Noel , Ratnasabapathy Risheka , Papadopoulou Deborah , Prague Julia , Abbara Ali , Comninos Alexander , Bloom Stephen , Dhillo Waljit

Background: Kisspeptin stimulates hypothalamic GnRH secretion resulting in gonadotrophin release and has the potential as a future therapeutic for infertility. Previous studies have observed that kisspeptin increases LH and to a lesser degree FSH when administered to healthy women, which may limit its therapeutic potential. However, studies in women with hypothalamic amenorrhoea show that i.v. infusions of kisspeptin-54 stimulated both LH and FSH equally. Chronic s.c. infusion...

ea0026pl2 | Making sense with thyroid hormone | ECE2011

Making sense with thyroid hormone

Forrest Douglas , Cordas Emily , Fu Yulong , Liu Hong , Lu Ailing , Ma Michelle , Ng Lily , Peeters Robin , Sharlin David

Thyroid hormone has long been known as a key developmental factor in human and model species. Insufficient thyroid hormone during development can impair the growth and maturation of diverse tissue and organ systems. One of the most serious risks associated with congenital hypothyroidism is defective brain maturation and mental retardation. However, in recent years, targeted mutagenesis of the thyroid hormone receptor genes in model species has expanded our understanding of the...