Endocrine Abstracts

Background: The evaluation of postoperative adrenal insufficiency (PAI) and hypothalamus–pituitary–adrenal (HPA) axis recovery in patients with adrenal incidentaloma (AI) undergoing unilateral adrenalectomy remains limited.Objectives: We aimed to identify predictive factors for PAI development and evaluate HPA axis recovery in AI patients undergoing unilateral adrenalectomy.Methods: We retrospectively analysed adrenal fun...

Congenital adrenal hyperplasia (CAH) is a disorder due to mutations of genes coding for adrenal steroidogenesis enzymes, commonly caused by 21α-hydroxylase enzyme deficiency. Severe impairment of 21α-hydroxylase synthesis results in the classic form of CAH (c-CAH) characterized by cortisol and aldosterone deficiency (salt wasting form - SW), or partial enzyme deficiency characterized by cortisol deficiency (simple virilizing form - SV); mild impairment of 21α-hy...

Background: Limited information exists on postoperative hypocortisolism and hypothalamuspituitary-adrenal axis recovery in patients with adrenal incidentaloma following unilateral adrenalectomy. We evaluated frequency of postoperative hypocortisolism and predictors for recovery in non-aldosterone- producing adrenocortical adenoma patients after unilateral adrenalectomy.Methods: A retrospective analysis of 32 adrenal incidentaloma patients originally incl...

Background: Acromegaly is associated with increased lean mass (LM) and reduced fat mass (FM), therefore body mass index is not a reliable parameter of body composition in this context. Moreover, the contributing factors to these alterations, along with their potential reversibility after achieving disease control, remain poorly understood. This study aimed to detect body composition alterations, as well as to investigate the impact of biochemical control and different medical ...

Introduction and Objectives of the Study: Combined oral contraceptives (COCs) are frequently prescribed for fertility control, however sexual dysfunction has been reported as a common side effect. In 2020, a novel progestin-only pill containing Drospirenone (DRSP) was approved as an oral contraceptive. To date, here is a notable dearth of data on the impact of DRSP on sexual function and impact on hormones, particularly regarding steroids. This study aims to investigate the po...

The potential independent role of growth hormone (GH) excess in sexual dysfunction of acromegalic male patients is poorly characterized. The aim of the current study was to evaluate the sexual function, in adult males with acromegaly, stratifying the cohort in “uncontrolled” and “controlled” disease. Data were retrieved from GONADIS, a national registry on gonadal status and reproductive and psycho-sexual function in patients affected by pituitary and adren...

Background: Since the preliminary epidemiological data concerning the coronavirus disease 2019 (COVID-19) has been availabe, clear sex disparity has been evident, with males, although not more frequently affected, often experiencing worse outcomes when compared to women. The short and long term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. The aim of the present study is to systematically review and meta-analyze all available data regardi...

Background: Varicocele repair is often suggested to improve reproductive outcomes, but there is no clear indications on which subjects are more likely to benefit from treatment. We assessed spermatogenetic and endocrine function of the testis in a population of young subjects with a 12-month follow-up following percutaneous treatment.Methods: We retrospectively reviewed data from 77 young patients (mean age 23.3 years, range 18–35) followed in our c...

Autoimmune thyroiditis and related complications represent a growing concern during pregnancy. Selenium is frequently present in nutraceuticals recommended for thyroiditis and pregnancy, given its advocated role in immunity, fertility and thyroid function. However, most evidences come from non-controlled studies. Materials and MethodsWe designed a multicenter, randomized, double-blind, placebo-controlled trial (Serena Study: NCT01465867) to evaluate the ...

Introduction: Adrenal insufficiency requires life-long glucocorticoid replacement. Conventional therapies fail to mimic endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling organ’s circadian function and are influenced by glucocorticoids. However, clock genes expression has never been investigated in patients with adrenal insufficiency (AI).Aim: To evaluate the effect of the timing of gluc...