Endocrine Abstracts

Background: Associations between obesity and adipomyokines, inflammatory marker, and level of physical fitness have not been well evaluated in severe obesity in children and adolescents.Method: Data on leptin, irisin, FGF21, hsCRP, glucose, insulin, physical fitness measured by arm curl test for upper extremity)and wall sit test for lower extremity were obtained in 266 participants who were recruited for ICAAN study, community- based multidisciplinary we...

Background: Adherence to recommended guideline for monitoring of glucose control and screening of diabetic complications has been demonstrated to prevent the chronic complications of diabetes. In Korea, the clinical audit for quality of diabetes care has been started in 2011. The aim of this study is to investigate the change of adherence to a process quality-of-care-indicator in diabetes after the initiation of audit in Korea.Methods: This retrospective...

Background: Regular monitoring of glucose control and screening of diabetic complication and adherence to treatment are cornerstones for prevention of chronic diabetic complications. The aim of this study is to investigate the association between quality of diabetes care and the development of chronic diabetes complications.Methods: This retrospective study was performed using the national health insurance claims database from the Health Insurance Review...

Background: TSH suppression therapy has been associated with hip and vertebral fracture. However, the relationship between TSH suppression and bone mineral density (BMD) remains controversial. The aim of this study was to evaluate the effect of TSH suppression therapy on cortical bone geometry in differentiated thyroid cancer (DTC) patients.Methods: This study included 122 subjects (19 men, 27 premenopausal women, and 75 postmenopausal women) who have be...

Introduction: NK cells are cytotoxic lymphocytes critical to innate immunity. The purpose of this study is to find out the difference in NK cell activity between type 2 diabetes patients and controls, and to investigate the association between NK cell activity and glucose control.Methods: Forty-nine subjects were enrolled in this study, with 23 type 2 diabetes patients and 26 normal glucose tolerant controls. Anthropometric and biochemical parameters wer...

Background: Korean red ginseng (KRG) has been shown to improve glucose tolerance and insulin resistance in several human studies. However, human studies on the effects of KRG on diabetic complications are lacking. We performed this study to investigate the effects of KRG administration on glucose metabolism and chronic diabetic complications in type 2 diabetes patients.Methods: This study was a randomized, double-blind, placebo-controlled trial. 83 type ...

Purpose: This study investigated the exercise-induced changes in novel adipokines (visfatin, chemerin, and apelin) related to obesity and metabolism, and their correlations with the changes in the measures of obesity and glucose homeostasis after the 8-wk exercise intervention.Methods: Forty metabolically heathy obese young males were randomly assigned either to control (C, n=12) or exercise group (Ex, n=28). The subje...

Silent corticotroph adenomas (SCAs) are difficult to distinguish from other non-functioning pituitary adenomas (NFPAs) preoperatively. This study assessed the preoperative clinical parameters associated with SCAs. After excluding patients with increased 24-h urinary free cortisol, 341 patients who underwent surgery for NFPAs during 2011–2016 with available preoperative combined pituitary function test (CPFT) and immunohistochemical staining results were enrolled. The pati...

Background: Cystic Fibrosis related diabetes affects 40-50% of adults with cystic fibrosis (CF). This can significantly affect pulmonary function and life expectancy. Kaftrio (Ivakaftor, tezacaftor and elexacaftor) has recently been licensed for use in CF. Previous data highlight that glucose regulation may be altered on commencing this treatment.Methods: Eight children and young people (CYP), aged 14 (12-15) years, who were diagnosed with CFRD aged 12.8...

Background: The presence of extathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). ETE is classified into gross ETE (gETE) and minimal ETE (mETE). The mETE was recently excluded from the T3 category in the TNM staging system. The purpose of this study is to compare the recurrence risk of mETE and gETE in PTC patients through propensity score matching analysis. And a comparison in the same way for pa...