Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1 | Adrenal cortex | ECE2014

Which serum cortisol after high dose short synacthen test, 30 or 60 min?

Ali Mansour Abbas , Ali Alhamza Ali Hussein , Almomin Ammar Mohamd Saead

Background: Short synacthen(cosyntropin)test, has replaced the insulin stress test as the first-line test to assess adrenal insufficiency. The aim of this study, was to determine the utility of the 30 and 60 min cortisol measurement in the high dose (250 μg) short synacthen test.Methods: Cross sectional study was conducted by reviewing the database of patients underwent short synacthen test in Al-Faiha Diabetes Endocrine and Metabolism Center (FDEMC...

ea0034p25 | Bone | SFEBES2014

Is the response to high dose oral vitamin D replacement predictable?

Chandrajay Deepak , Milic Marina , Al-Khaili Gwen , Abbas Afroze , Orme Stephen

In our institution, an observed loading dose of oral colecalciferol (D3) 300 000 units is used for treatment of vitamin D deficiency (Vit D <30 nmol/l), with subsequent re-evaluation at 6 weeks and 3 months. We evaluated the follow-up of all the patients who received loading dose colecalciferol against adherence to this protocol.Method: All patients who received observed loading dose of colecalciferol for a 1-year period were included. Demographic, c...

ea0032p1032 | Thyroid (non-cancer) | ECE2013

Coexistent toxic adenoma and Riedel thyroiditis: a case report

Tam Abbas Ali , Ozdemir Didem , Ersoy Pamir Eren , Kilicarslan Aydan , Ersoy Reyhan , Cakir Bekir

Riedel thyroiditis is a rare chronic inflammatory disease of the thyroid. It is characterized by replacement of normal parenchyma with dense fibrotic tissue. Peripheral tissues might also be affected and this may cause airway obstruction, dysphagia, recurrent laryngeal nerve palsy and hypoparathyroidism. We report a patient with toxic adenoma previously treated with radioactive iodine and histopathologically confirmed Riedel thyroiditis.Case: A 61 years ...

ea0032p1055 | Thyroid (non-cancer) | ECE2013

Does a normal thyroid ultrasound image always accompany normal thyroid functions test results?

Tam Abbas Ali , Kaya Cafer , Ucler Rifki , Dirikoc Ahmet , Ersoy Reyhan , Cakir Bekir

Introduction: Nowadays, ultrasonography (USG) is being used very commonly and indispensably for diagnosing thyroid diseases. Heterogeneous appearance of thyroid parenchyma is associated with positivity for thyroid autoantibody and hypofunctioning of thyroid gland. On the other hand, it is not determined whether thyroid parenchyma appearing totally of normal ecogenity on USG is related to presence normal thyroid function tests or otherwise. The objective of our study was evalua...

ea0031p272 | Pituitary | SFEBES2013

Rare case of round blue cell pituitary tumour with probable hypothalamic involvement

Zhyzhneuskaya Sviatlana , Mitchell Anna , Abbas Jehangir , Ganguri Murali , Biswas Swethajit , Perros Petros , Kane Philip , Arutchelvam Vijayaraman

Introduction: We submit a rare presentation of round blue cell pituitary tumour complicated by cranial diabetes insipidus following transphenoidal surgery.Case history: 47-year-old lady with severe headache was diagnosed with a 10 mm non functioning pituitary macro adenoma. Initial plan for conservative management was revised as she developed sixth cranial nerve palsy, bi temporal hemianopia and rapidly enlarging pituitary tumour to 20×18×19 mm...

ea0025p117 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Differential regulation of the neurotrophins, NGF and BDNF, and their receptors in the myometrium of women affected by adenomyosis

Taylor Anthony , Hawes Michael , Kalathy Vijay , Abbas Muna , Mehasseb Mohamed , Habiba Marwan

Adenomyosis is an oestrogen-dependent uterine disease where ectopic, non-neoplastic endometrium is histologically observed within the myometrium. Its incidence ranges between 5 and 70% and although presenting symptoms; menorrhagia (40–50%), dysmenorrhoea (10–30%) and metrorrhagia (10–12%) are well known, its aetiopathology remains unclear. The neurotrophin, nerve growth factor (NGF), has been implicated in the aetiopathology of adenomyosis, especially in the tam...

ea0021oc1.1 | Diabetes and metabolism | SFEBES2009

IGF1 receptor and insulin receptor stoichiometry is a critical determinant of nitric oxide bioavailablity

Abbas Afroze , Viswambharan Hema , Imrie Helen , Rajwani Adil , Wheatcroft Stephen , Grant Peter , Kearney Mark

Introduction: Accumulating evidence suggests a role for IGF1 in insulin resistance and cardiovascular disease. IGF1 enhances glucose uptake and nitric oxide (NO) production, via similar mechanisms to insulin. Previously we have reported a mouse model with global heterozygous knockout of the IGF1 receptor (IGF1RKO) that has enhanced insulin sensitivity and increased nitric oxide (NO) production in the vasculature.Methods: To investigate this further we us...

ea0056p853 | Pituitary - Clinical | ECE2018

Presence of empty sella in a patient with clinical and biochemical diagnosis of acromegaly

Bestepe Nagihan , Aydin Cevdet , Tam Abbas Ali , Ercan Karabekir , Ersoy Reyhan , Cakir Bekir

Introduction: Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It is characterized by progressive somatic disfigurement and systemic manifestations. Empty sella (ES) is an anatomical condition comprising sella turcica that is partially or completely filled with cerebrospinal fluid mainly due to intrasellar herniation of subarachnoid space. Primary ES may be associated with endocrine dysfunction ...

ea0056p1081 | Thyroid (non-cancer) | ECE2018

Coincidental prolactinoma and parathyroid adenoma in a patient with negative MEN1 and MEN4

Faki Sevgul , Aydin Cevdet , Cuneyt Bilginer Muhammet , Yukselguler Bagdegul , Abbas Tam Ali , Kilic Mehmet , Cakir Bekir

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is associated with neoplasia and hyperfunction of the parathyroid and pituitary glands, pancreatic islet cells, and neuroendocrine cells of the gut. Many authors advocate routine subtotal or total parathyroidectomy and autotransplantation for these patients. Here we demostrate negative MEN1 and MEN4 gene mutation analysis in a case with prolactinoma and a large parathyroid adenoma that could not be localized with preope...

ea0056p1137 | Thyroid cancer | ECE2018

ABO blood groups, Rh factor and thyroid cancer risk: To ‘B’ or not to ‘B’

Tam Abbas Ali , Ozdemir Didem , Faki Sevgul , Bilginer Muhammet Cuneyt , Ersoy Reyhan , Cakir Bekir

Aim: In this study, we aimed to evaluate ABO blood groups and Rh factor in patients with thyroid cancer. We also assessed whether the ABO/Rh factor had any effect on prognosis, agressive features and advanced stage of thyroid malignancies.Methods: Medical records of patients who underwent thyroidectomy between December 2006 and September 2014 were evaluated retrospectively. Demographical and clinical features, cytological results (according to Bethesda c...