Searchable abstracts of presentations at key conferences in endocrinology

ea0014p196 | (1) | ECE2007

Continuous administration of dihydrotestosterone or letrozole to immature female rats results in polycystic ovary syndrome characteristics at adult age

Mannerås Louise , Lystig Theodore , Holmäng Agneta , Ottosson-Lönn Malin , Stener-Victorin Elisabet

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity and insulin resistance. Since hyperandrogenism is a PCOS key feature, the aim was to evaluate the effects of androgen receptor activation in terms of continuously administration, beginning pre-pubertal, of either the non-aromatizable androgen dihydrotestosterone (DHT) or the aromatase inhibitor letrozole (L), on...

ea0004p38 | Diabetes, metabolism and cardiovascular | SFE2002

Sex difference in serum leptin concentrations in Chinese type 2 diabetic patients with or without nephropathy

Chan N , Chan W , Ma R , Ng M , Lee Z , Lai C , Tong P , So W , Chan J

Objectives: To investigate whether there is a sex difference in serum leptin concentration in Chinese Type 2 diabetic patients with and without nephropathy.Methods: Early morning fasting serum leptin concentrations were measured in 34 Type 2 diabetic patients (mean age 62.1) with nephropathy (creatinine 120-450micromol/l and spot urinary albumin creatinine ratio (ACR) > 25 mg/mmol), 12 newly diagnosed diabetic subjects (mean age 62.5) with normoalbumi...

ea0103p14 | Diabetes 1 | BSPED2024

Diabetic retinopathy screening in laotian children with diabetes: a collaboration between singapore national eye centre and action4diabetes

Ng Sze , Manivong Amphayvanh , Phommachack Daoheuang , Khambuapha Khamtavanh , Ooi6 Fiona , Foo Reuben , Tan Anna , Lek Ngee

Background: Laos is a LMIC in South-east Asia (SEA) where health coverage does not provide for insulin and blood glucose testing. Before 2016, no person was known to have survived type 1 diabetes (T1D). Action4Diabetes (A4D) has since been providing insulin and blood glucose testing kits for Laotian patients with T1D. As the patients are now surviving and living with T1D, early detection of diabetes-related complications becomes imperative. In March 2024, a diabetic retinopath...

ea0077p41 | Metabolism, Obesity and Diabetes | SFEBES2021

Investigating 2-oleoylglycerol responsive neuronal pathways

Cheng Sijing , Norton Mariana , Roberts Anna , Martin Alonso Aldara , Phuah Phyllis , Tulloch Emily , Vinette Heloise , Ng Kaa-Yung , Owen Bryn , Hanyaloglu Aylin , Murphy Kevin

Dietary fat intake is an important source of energy and in excess can drive the development of obesity. Investigating how dietary fat intake alters neuronal activity in the brain and drives behavioural changes may help us understand the mechanisms behind high fat diet induced obesity. 2-oleoyglycerol (2-OG) is a naturally occurring unsaturated long chain fatty acid produced by fat digestion in the gut and a ligand of G protein-coupled receptor 119 (GPR119). Published data has ...

ea0077p243 | Reproductive Endocrinology | SFEBES2021

The effect of exogenous kisspeptin administration in a novel mouse model of hypothalamic amenorrhoea

Shrewsbury Jed V , Ng Kah-Yan , McIntyre Caitlin , Li Xiao Feng , Phylactou Maria , O’Byrne Kevin T , Abbara Ali , Dhillo Waljit S , Owen Bryn M

Kisspeptin is integral to hypothalamo-pituitary-gonadal (HPG) axis function and overall fertility. Functional deficiency of GnRH/lH secretion in the central reproductive disease, hypothalamic amenorrhoea (HA), indicates diminished kisspeptin signalling. Clinical trials have shown kisspeptin to be a viable therapeutic intervention. However, repeated administration led to the development of tachyphylaxis and so is likely a problem for future implementation. Indeed, elevated LH r...

ea0068p24 | Abstracts | UKINETS2019

Improving diagnosis times as part of the transformation of the South Wales NET Service

Amin Kapish , Gruber Mei-Yin , Shayan-Arani Holleh , Taylor Rebecca , Powell Catherine , Cook Katherine , Benny Ankita , Ng Sheryl , Christian Adam , Khan Mohid S

Background: Transformation of the South Wales NET service in late 2017 introduced new specialised staff, gastroenterology-led clinics and MDTs with a particular emphasis on educating referring specialties on NETs. Data has shown patient experience, satisfaction rates, quality of life and gastrointestinal symptom scores have all improved. This study aims to describe findings from new NET service data for: referrals into the service, diagnosis times after symptoms, and initial s...

ea0049gp65 | Developmental & Protein Endocrinology | ECE2017

3-year safety and efficacy Update of the VERTICAL & VISTA trials of somavaratan (VRS-317), a long-acting rhGH, in children with Growth Hormone Deficiency (GHD)

Miller Bradley S. , Moore Wayne V. , Fechner Patricia Y. , Van Meter Quentin L. , Fuqua John S. , Ng David , Humphriss Eric , Charlton R. William , Bright George M.

Requirement for daily rhGH injections is a treatment burden that can compromise adherence and efficacy in patients with GHD. Somavaratan is a novel long-acting rhGH fusion protein in clinical development for pediatric and adult GHD. In a multicenter, randomized Phase 1b/2a study, somavaratan significantly improved height velocity (HV) and IGF-I in pre-pubertal children with GHD. Preliminary efficacy and safety in subjects who have completed 3 years of somavaratan treatment are...

ea0037ep786 | Pituitary: clinical | ECE2015

Cushing's Syndrome: An ominous and commonly forgotten cause of hypokalaemia

Seow Cherng Jye , Ng Zhiguang , Teo Claire Min-Li , Lum Grace , Chow Minyang , Ong Chin Ee , Lai Tian Ray , Ryanputra Davin

Introduction: We report a patient with hypokalaemia secondary to Cushing’s syndrome (CS) to reinforce this commonly forgotten association.Case report: A 57 years old lady with newly diagnosed hypertension, hyperlipidaemia and diabetes mellitus presented with persistent hypokalaemia for evaluation. She had tinea corporis but otherwise did not look Cushingoid. Investigations: K 2.6 (RI: 3.50–5 mmol/l), HCO3 35 (RI: 19–31 mmol/l), ...

ea0037ep854 | Thyroid cancer | ECE2015

Primary thyroid lymphoma: an ominous and commonly forgotten association with Hashimoto's thyroiditis

Seow Cherng Jye , Ryanputra Davin , Lai Tian Ray , Ong Chin Ee , Chow Minyang , Lum Grace , Teo Claire Min-Li , Ng Zhiguang

Introduction: Primary thyroid lymphoma (PTL) is rare and constitutes 2–5% of thyroid malignancies. The risk however increases with background Hashimoto’s thyroiditis. (HT) We report a patient with HT complicated by thyroid lymphoma and did a literature review on this topic.Case presentation: A 61-years-old Chinese lady with background HT on levothyroxine presented with an enlarging goitre of 6 months duration. There was weight loss of 3–4 ...

ea0035p586 | Endocrine tumours and neoplasia | ECE2014

The anti-proliferative effect of anti-EGFR tyrosine kinase inhibitor in combination with mitotane on H295R adrenocortical cancer cells

Dworakowska Dorota , Dudka Dorota , Weistman Gregory , King Peter , Diaz-Cano Salvador , Korbonits Marta , Grossman Ashley B , Aylwin Simon , Schulte Klaus-Martin , Sworczak Krzysztof , Ng Tony

Introduction: Adrenocortical carcinoma (ACC) is a rare disease with a poor prognosis and limited therapeutic options. Mitotane is considered as a first-line therapy but only 30% of the patients showing an objective tumour response.Erlotinib and gefitinib (tyrosine kinase inhibitors – TKI) inhibit the epidermal growth factor receptor (EGFR), which is highly expressed and occasionally mutated in various cancers. EGFR expression was found to be a good ...