Searchable abstracts of presentations at key conferences in endocrinology

ea0066oc7.4 | Oral Communications 7 | BSPED2019

Monitoring lipid profiles in children and young people with type 1 diabetes mellitus: what should we do with these results?

Park Julie , Bowker Tabitha , Ghatak Atrayee , Mehta Fulya , Deakin Mark , Paul Princy

Introduction: Evidence is currently limited regarding the management of abnormal lipid profiles in children and young people (CYP) with Type 1 Diabetes Mellitus (T1DM). ISPAD recommend monitoring every five years and statin use to maintain LDL cholesterol <3.4 mmol/L1. Guidance is specific to LDL. NICE guidelines do no recommend routine screening for CYP with T1DM.Methodology: We reviewed all lipid profiles (including cholesterol, triglyce...

ea0062oc3 | Oral Communications | EU2019

A case of Birt-Hogg-Dubé syndrome presenting with a rare oncocytic non-secretory phaeochromocytoma

MacFarlane James , Plichta Piotr , Park Soo-Mi , Marker Alison , Krishnan Leena , Hand Sadiyah , Myint Khin Swe

Case history: Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant disorder caused by heterozygous pathogenic variants in the FLCN gene encoding folliculin on chromosome 17p11, first described clinically in 1975. It is a ‘hamartomatous’ disorder usually manifesting with pulmonary cysts, benign cutaneous tumours and conferring a high risk of renal malignancy. A 43 year old man had a 34 x 22 mm right adrenal nodule discov...

ea0063oc1.1 | Calcium and Bone | ECE2019

Genetic testing for hereditary hyperparathyroidism in a large UK cohort

Mariathasan Sashi , Andrews Katrina , Thompson Edward , Armstrong Ruth , Park Soo-Mi , Casey Ruth

Primary hyperparathyroidism (PHPTH) is a common endocrine disorder and it is estimated that 10% of cases are hereditary, related to syndromes including; multiple endocrine neoplasia (MEN) type 1, MEN type 4, MEN2A and hereditary hyperparathyroidism jaw tumour syndrome. Further hereditary cases can occur in the absence of syndromic features such as familial hypercalcemia hypocalcuria. Identifying cases of hereditary PHPTH enables a personalised medicine approach. Current guidel...

ea0063gp225 | Adrenal and Neuroendocrine - Clinical (1) | ECE2019

Activation of the ATM/Akt/CREB/eNOS expression signaling axis by aphidicolin increases nitric oxide production to attenuate endothelial cell death

Cho Du-Hyong , Park Jung-Hyun , Lee Jee Young , Lee Hyeon-Ju , Jo Inho

Previously, we reported that aphidicolin acutely increases nitric oxide (NO) production in bovine aortic endothelial cells (BAECs) by increasing phosphorylation of endothelial nitric oxide synthase at serine 1179 (p-eNOS-Ser1179) and decreasing phosphorylation at serine 116 (p-eNOS-Ser116) without altering eNOS protein expression. Here, we demonstrate that prolonged treatment with aphidicolin (over 24 h) also increased NO production in BAECs. Unlike the a...

ea0063p67 | Calcium and Bone 1 | ECE2019

The effect of steroid hormone on the expression of the calcium-processing proteins in the immature rat brain

Go Seon Myeong , Park Seon Young , Lee Jae-Hwan , Jeung Eui-Bae

The cytosolic calcium concentration is regulated by calcium-processing proteins such as transient receptor potential cation channel subfamily V member 5 (TRPV5), TRPV6, sodium-calcium exchanger 1 (NCX1) and plasma membrane Ca2+ ATPase 1 (PMCA1). Those calcium-processing proteins are important for physiological functions in the brain. The effects of steroid hormones on calcium-processing protein expressions in the brains are undescribed. Thus, the effects of steroid ...

ea0063p90 | Calcium and Bone 1 | ECE2019

Epidemiology of hypoparathyroidism in Korea

Jee Eun Hyun , Lee Joon-Hyop , Park So Young , Ahn Song Vogue , Lee Sihoon

Background: The National Health Insurance Service of South Korea is considered to be one of the most effective systems in the world with high accessibility to health care for all Koreans including foreign residents in the country as many as 50 M people. The accumulative information on the behaviors and the statistics of healthcare use based on the National Health Insurance Sharing Service Database has become important for medical research as a nationwide surveillance.<p cl...

ea0063p223 | Diabetes, Obesity and Metabolism 1 | ECE2019

The association between serum cystatin C and carotid artery intima-media thickness in Korean type 2 diabetic patients

Kim Soo-Kyung , Kim Se-Hwa , Kim Kyung-Soo , Park Seok-Won , Cho Yong-Wook

Background: There are several markers of renal function such as estimated glomerular filtration rate (GFR) calculated by serum creatinine and cystatin C and urinary albumin-creatinine excretion ratio (ACR). Recently, a few studies showed relationships between markers of renal function and carotid arterty intima-media thickness (IMT), but the results were inconsistent. The aim of this study is to compare serum cystatin C as risk factors for atherosclerosis in Korean type 2 diab...

ea0063p505 | Calcium and Bone 2 | ECE2019

Impact of three doses of vitamin D on serum 25(OH)D parathyroid hormone in overweight and obese schoolchildren: A single blind randomized clinical trial

Asghari Golaleh , Wagner Carol L , Yuzbashian Emad , Park Yeonhee , Mirmiran Parvin , Hosseinpanah Farhad

Introduction: Trials on children and adolescents with excess weight are limited and lack parathyroid hormone (PTH) measures as a surrogate marker of vitaminD status in skeletal health. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed at determining vitamin D requirement to increase 25(OH)D and suppress PTH concentrations in overweight and obese school children.Methods: The current st...

ea0063p995 | Environment, Society and Governance | ECE2019

Second-phase validation of developmental toxicity test using embryoid body’s area

Lee Jae-Hwan , Park Seon Mi , Jung Eui-Man , Jeung Eui-Bae

The embryoid body test (EBT) is a developmental toxicity test method that assesses the half inhibitory concentrations of substances in the area of embryoid bodies (EBs), and in the viability of mouse embryonic stem cells (ESCs) and fibroblasts (3T3 cells). In the previous pre-validation study evaluated the predictive accuracy of the EBT using 26 coded test substances and highly accurate (above 80%) when substances were classified using the predictive model. EBT used two same e...

ea0049gp42 | Bone & Calcium Homeostasis 1 | ECE2017

Expression of hypoxia-inducible factor-1α in Calbindin-D9k Knockout mice

Kang Song Ai , Park Seon Young , An Jin Yong , Jeung Eui-Bae

Introduction: Hypoxia-inducible factors (HIF) are the key transcription factor induced by hypoxic condition, which regulate expression of specific target genes including angiogenic factors, erythropoietin, glucose transporters, and glycolytic enzymes. Recently, many studies connected to intracellular calcium levels and regulation of HIF-1α protein level. Calbindin-D9k is a cytosolic calcium-binding protein and compensate with other calcium transporter protein f...