Searchable abstracts of presentations at key conferences in endocrinology

ea0038p173 | Neoplasia, cancer and late effects | SFEBES2015

A management dilemma – emergency treatment of primary hyperparathyroidism in suspected but unconfirmed multiple endocrine neoplasia type 1

Khurana Ramneet , Gandhi Ashu , Issa Basil

A 27 year old male patient with severe cardiomyopathy secondary to Epirubicin chemotherapy for rhabdomyosarcoma in infancy was noted to be hypercalcaemic during the course of admission for severe inotrope dependant congestive cardiac failure. Biochemical investigations confirmed a diagnosis of primary hyperparathyroidism (corrected Calcium 3.10 mmol/l, PTH 22 pmol/l, Vitamin D 77 nmol/l).His brother had undergone trans-sphenoidal pituitary surgery for ac...

ea0037ep1291 | Clinical Cases–Thyroid/Other | ECE2015

Nephrotic syndrome due to membranous nephropathy as the cause of rising TSH levels or primary hypothyroidism as the cause of nephrotic syndrome? A case report

Patel Sohini , Gandhi Nirav , Shakher Jayadave

We present a case of a 52-year-old man with a past medical history of primary hypothyroidism on treatment, presenting with elevated TSH levels, suggesting inadequate thyroxine (T4) replacement. The patient was managed with 200 μg of T4 for 14 years with no compliance issues. TSH levels failed to normalise despite increasing the dose of T4. In addition to elevated TSH levels the patient noted progressive leg swelling and associated shortnes...

ea0031p55 | Clinical biochemistry | SFEBES2013

Impact of hyponatraemia in critically ill patients

Shakher Jayadave , Gandhi Nirav , Raghuraman Govindan

Introduction: Hyponatraemia, defined as serum sodium <135 mmol/l is one of the commonest electrolyte abnormalities seen in patients admitted to acute hospitals and is associated with increased morbidity and mortality. Impact of this condition is not adequately measured in critically ill patients admitted to intensive care unit. The aim of this observational study was to assess the incidence and outcomes of patients admitted to intensive care unit (ICU) in a UK based settin...

ea0007p119 | Endocrine tumours and neoplasia | BES2004

Bilateral laparoscopic adrenalectomy for ACTH-dependent Cushing's syndrome

Newell-Price J , Gandhi A , Harrison B

Background: Management of ACTH-dependent Cushing's syndrome (ACTH-CS) remains a challenge. In the past 2 decades open bilateral adrenalectomy, associated high morbidity and long post-operative in-patient stay, has usually been reserved for cases of failed transsphenoidal surgery (TpS) and radiotherapy (RT), or where the source of ACTH is not found. Laparoscopic adrenalectomy is a significant advance with low morbidity and mortality.Aim: To assess the eff...

ea0048cp15 | Poster Presentations | SFEEU2017

Pituitary apoplexy presenting with hypopituitarism and a generalised tonic clonic seizure

Gandhi S E , Kueh C J L , Perry C

Case history: A 28 year old male presented following his first generalised tonic clonic seizure in the context of a headache with mild photophobia, nausea and vomiting. He was haemodynamically stable, euvolaemic and had no focal neurological deficit, but was mildly disoriented. He had reported cannabis and MDMA use 8 days prior to his presentation. The patient was profoundly hyponatraemic with a serum sodium of 108.Investigations: Serum osmolality was 22...

ea0035p273 | Clinical case reports Thyroid/Others | ECE2014

Heparin-induced hyperkalaemia in a patient with type 2 diabetes: a case report

Gandhi Nirav , Sharif Walid , Shakher Jayadave , Sharif Zuhair

Introduction: Heparin is extensively used amongst different medical and surgical specialities for prophylaxis and treatment of venous thromboembolism and suspected coronary syndromes. Hyperkalaemia is known to occur as an effect of heparin treatment through its action on the renin-angiotensin system, especially when used at treatment doses. Hyperkalaemia is a serious electrolyte disturbance, which may precipitate potentially fatal cardiac arrhythmias. We describe a case of a p...

ea0034p153 | Clinical practice/governance and case reports | SFEBES2014

The prevalence and mortality in hospitalised patients with mild, moderate, and severe hyponatremia

Shakher Jayadave , Gandhi Nirav , Shepherd Lisa , Pitt Christopher , Chatha Kamaljit

Introduction: Hyonatraemia, defined as serum sodium <135 mmol/l is the commonest electrolyte abnormalities and is associated with increased morbidity and mortality.Aim: To determine the prevalence of mild, moderate, and severe Hyponatraemia in the hospitalised patients and estimate mortality between these three groups and compared to Normonatraemia.Methods: This is a retrospective audit in patients admitted to hospital from Jul...

ea0011p37 | Bone | ECE2006

A comparative study of neck ultrasonography, sestamibi scan and parathyroid surgery findings

Dixit KCS , Norris AJ , Wiles PG , Savage MW , Khan AN , Gandhi A

Background: Many Endocrinologists believe that preoperative localisation/lateralization in patients undergoing initial neck exploration for primary hyperparathyroidism is unimportant because of high cure rate in the hands of experienced surgeons. Tcm-MIBI imaging has a sensitivity of 70 to 95% in localizing parathyroid tumors. Ultrasonography has lower sensitivity but is noninvasive and relatively cheap. Unilateral surgical exploration has potential benefits including reduced ...

ea0103p109 | Gonadal, DSD and Reproduction 2 | BSPED2024

The link between non ketotic hyperglycinaemia (NKH) and precocious puberty in a young child: -a case report

Mohamed Haniffa Fathima , Gandhi Dillip , Agwu Juliana Chizo.

Non ketotic hyperglycinaemia (NKH)is due to a mutation in the glycine cleavage enzyme system leading to accumulation of glycine in the body especially in the spinal cord and brain. Patients typically present with neurological problems. Some NKH symptoms involve the inhibitory strychnine-sensitive glycine receptors, whereas the pathogenesis of seizures involves the excitatory strychnine-insensitive glycine receptors belonging to the N-methyl-D-aspartate (NMDA) receptor complex....

ea0081p500 | Thyroid | ECE2022

Immune check point inhibitors- induced thyroid disorders -would you recognise them?

Gandhi Jegadeshwaran , Mahamud Bashir , Bell Janessa , Ahmed Ghada , Elshowaya Suhier , Rehmani Hassan , Nikookam Khash , Mlawa Gideon

Introduction: Development and progression of cancers is multifactorial encompassing several mechanisms that aid its proliferation. One of the hallmarks of cancer progression is inhibition of the immune system. Cancer cells can activate different immune checkpoint are pathways that harbour inhibitory or stimulatory mechanisms that enabled self-tolerance and assist with immune response. Through activation of immune checkpoint pathways cancers can suppress immune response against...