Endocrine Abstracts

Objective: Cushing’s disease is caused by hypercortisolism due to adrenocorticotropic hormone (ACTH) hypersecretion from functioning pituitary adenomas (FCA). Endoplasmic reticulum (ER) protein processing is important for hormone production and is upregulated in FCA as shown previously. ER protein processing can be disturbed by ER stress. We hypothesized that ACTH production and secretion can be inhibited by agents that cause ER stress by attenuating ER protein processing...