Endocrine Abstracts

Background: Graves’ disease (GD) is the most common form of hyperthyroidism in Sweden. About 2000 patients are affected by GD annually (incidence 21/100 000) and a majority are women in working age. GD can be overwhelming for the affected patient. Health care professionals do their best to meet the patients’ needs, but can we do more? The aim of this study was to explore patients’ experiences of being affected by GD to improve healthcare.M...

Background: Graves’ disease (GD) mainly affects women in all age groups. Although most patients improve with treatment, patients still often experience cognitive and psychological symptoms. The ambiguity surrounding these persistent mental symptoms contributes to frustration for both patients and healthcare professionals. The study aims to provide in-depth insights into how healthcare professionals perceive the care of patients with GD. Through interviews, we aim to under...

Background/aims: Oxidative stress and inflammation play a role in development of diabetic kidney disease. Postprandial hyperglycemia and hyperlipidemia are speculated to be associated with increased oxidative stress and inflammation. The aim was to examine the effect of meal composition on post-prandial risk markers for kidney disease among those with type 2 diabetes (T2D) and healthy subjects (HS).Material/methods: On four occasions 21 patients with T2D...

Introduction: Neonatal events may contribute to the development of disorders such as type 2 diabetes and obesity at adult age. We have previously shown that neonatal testosterone (T) programming of female rats is followed by insulin resistance and changes in adipose tissue distribution with centralization of body fat. Therefore, the aim of this study was to examine the effects of neonatal injection of T, estradiol (E) or dihydrotestosterone (DHT) on insulin sensitivity and siz...

Objective: Mental fatigue (MF) is part of the concept of mental illness but is poorly established. Pathological MF occurs in many diseases and greatly reduces both quality of life (QoL) and work capacity. In Graves’ disease (GD) that often affects women of working age, about 40% of patients show MF after the acute symptoms have been treated. MF can occur alone, but also in combination with depression or anxiety and women are more than twice as likely as men to be on long-...

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity and insulin resistance. Since hyperandrogenism is a PCOS key feature, the aim was to evaluate the effects of androgen receptor activation in terms of continuously administration, beginning pre-pubertal, of either the non-aromatizable androgen dihydrotestosterone (DHT) or the aromatase inhibitor letrozole (L), on...

Background: Perfluoroalkyl Substances (PFAS) have drawn much attention due to environment bioaccumulation potential and their presence worldwide in human blood. Exposure to PFAS is suspected to induce endocrine-disrupting hormonal effects and may be involved in the development of type 2 diabetes (T2D). However, epidemiological evidence is scarce and inconsistent.Objective: We aimed to investigate the association of PFAS plasma levels on the risk of devel...

Objective: Pregnant women worldwide are at risk for mild iodine deficiency (ID) due to transfer of iodine through placenta, increased glomerular filtration of iodine and higher maternal thyroid hormone production for foetal needs. Studies show that mild ID involves normal thyroid hormone levels but may lead to increased thyroglobulin levels resulting from an increased maternal thyroid volume through changed thyroid metabolism. When assessing thyroid hormones during pregnancy, ...

Background: Somatostatin receptor ligands (SRLs) are first-line standard-of-care therapies for gastroenteropancreatic neuroendocrine tumours (GEP-NETs), showing efficacy in tumour and symptom control with an established safety profile. However, disease progression may occur despite standard-dose SRL treatment, requiring more aggressive and toxic treatments. Retrospective/non-randomized data suggest higher-dose SRLs may benefit patients with GEP-NETs who do not respond to stand...

Background: Somatostatin analogues (SSAs) are first-line standard of care therapies for gastroenteropancreatic neuroendocrine tumors (GEP-NET), showing efficacy in tumor/symptom control with an established safety profile. Yet, disease progression may occur despite standard-dose SSA treatment, requiring more aggressive and toxic therapies. Retrospective/non-randomized data suggest higher-dose SSAs may benefit patients with GEP-NET who do not respond to standard-dose treatment a...