Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps1-02-09 | Graves’ Disease | ETA2023

Patients` experience of being affected by graves`disease-the initial 3 month-phase

Lindo Agneta , Rivera Johansson Angelica , Fors Andreas , Filipsson Nystrom Helena

Background: Graves’ disease (GD) is the most common form of hyperthyroidism in Sweden. About 2000 patients are affected by GD annually (incidence 21/100 000) and a majority are women in working age. GD can be overwhelming for the affected patient. Health care professionals do their best to meet the patients’ needs, but can we do more? The aim of this study was to explore patients’ experiences of being affected by GD to improve healthcare.M...

ea0101ps1-08-06 | Hyperthyroidism | ETA2024

Healthcare professionals’ experiences of caring for patients with gravés disease- an interview study

Lindo Agneta , Alsen Sara , Fors Andreas , Filipsson Nystrom Helena

Background: Graves’ disease (GD) mainly affects women in all age groups. Although most patients improve with treatment, patients still often experience cognitive and psychological symptoms. The ambiguity surrounding these persistent mental symptoms contributes to frustration for both patients and healthcare professionals. The study aims to provide in-depth insights into how healthcare professionals perceive the care of patients with GD. Through interviews, we aim to under...

ea0049ep557 | Diabetes complications | ECE2017

Meal composition affects risk markers for kidney disease differently in type 2 diabetes and healthy subjects

Olofsson Camilla , Hilding Agneta , Orsini Nicola , Andersson Inga-Lena , Torffvit Ole , Brismar Kerstin , Ekberg Neda Rajamand

Background/aims: Oxidative stress and inflammation play a role in development of diabetic kidney disease. Postprandial hyperglycemia and hyperlipidemia are speculated to be associated with increased oxidative stress and inflammation. The aim was to examine the effect of meal composition on post-prandial risk markers for kidney disease among those with type 2 diabetes (T2D) and healthy subjects (HS).Material/methods: On four occasions 21 patients with T2D...

ea0014p197 | (1) | ECE2007

Neonatal sex steroid exposure of female rats results in insulin resistance and enlarged mesenteric adipocytes

Alexanderson Camilla , Lystig Theodore , Stener-Victorin Elisabeth , Lönn Malin , Holmäng Agneta

Introduction: Neonatal events may contribute to the development of disorders such as type 2 diabetes and obesity at adult age. We have previously shown that neonatal testosterone (T) programming of female rats is followed by insulin resistance and changes in adipose tissue distribution with centralization of body fat. Therefore, the aim of this study was to examine the effects of neonatal injection of T, estradiol (E) or dihydrotestosterone (DHT) on insulin sensitivity and siz...

ea0101ps1-08-03 | Hyperthyroidism | ETA2024

High frequency of mental fatigue after treatment of graves’ hyperthyroidism but low rate of sick-leave – report from a longitudinal cohort in sweden

Andersson Cathrin , Tammelin Karin , Lindo Agneta , Holmberg Mats , Filipsson Nystrom Helena

Objective: Mental fatigue (MF) is part of the concept of mental illness but is poorly established. Pathological MF occurs in many diseases and greatly reduces both quality of life (QoL) and work capacity. In Graves’ disease (GD) that often affects women of working age, about 40% of patients show MF after the acute symptoms have been treated. MF can occur alone, but also in combination with depression or anxiety and women are more than twice as likely as men to be on long-...

ea0014p196 | (1) | ECE2007

Continuous administration of dihydrotestosterone or letrozole to immature female rats results in polycystic ovary syndrome characteristics at adult age

Mannerås Louise , Lystig Theodore , Holmäng Agneta , Ottosson-Lönn Malin , Stener-Victorin Elisabet

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction, hyperandrogenism, abdominal obesity and insulin resistance. Since hyperandrogenism is a PCOS key feature, the aim was to evaluate the effects of androgen receptor activation in terms of continuously administration, beginning pre-pubertal, of either the non-aromatizable androgen dihydrotestosterone (DHT) or the aromatase inhibitor letrozole (L), on...

ea0056p523 | Endocrine Disruptors | ECE2018

Plasma levels of perfluoroalkyl substances and risk of type II diabetes mellitus: a prospective nested case-control study

Donat-Vargas Carolina , Bergdahl Ingvar A. , Tornevi Andreas , Wennberg Maria , Sommar Johan , Kiviranta Hannu , Rantakokko Panu , Rolandsson Olov , AEkesson Agneta

Background: Perfluoroalkyl Substances (PFAS) have drawn much attention due to environment bioaccumulation potential and their presence worldwide in human blood. Exposure to PFAS is suspected to induce endocrine-disrupting hormonal effects and may be involved in the development of type 2 diabetes (T2D). However, epidemiological evidence is scarce and inconsistent.Objective: We aimed to investigate the association of PFAS plasma levels on the risk of devel...

ea0101ps2-18-05 | Pregnancy | ETA2024

Trimester specific thyroid hormone reference range in mild iodine deficiency compared to normal iodine nutrition

Eriksson Janna , Manousou Sofia , Filipson Nystrom Helena , Lindo Agneta , Landberg Eva , Pettersson Pablo Paul , Olsson Anders , Lilliecreutz Caroline

Objective: Pregnant women worldwide are at risk for mild iodine deficiency (ID) due to transfer of iodine through placenta, increased glomerular filtration of iodine and higher maternal thyroid hormone production for foetal needs. Studies show that mild ID involves normal thyroid hormone levels but may lead to increased thyroglobulin levels resulting from an increased maternal thyroid volume through changed thyroid metabolism. When assessing thyroid hormones during pregnancy, ...

ea0081p646 | Endocrine-Related Cancer | ECE2022

Methodology of the SORENTO clinical trial: assessing the efficacy and safety of high exposure octreotide subcutaneous depot in patients with GEP-NETs

Ferone Diego , Capdevilla Jaume , Ang Chan Jennifer , de Herder Wouter W , Halperin Daniel , Mailman Josh , Singh Simron , Dorkhan Mozhgan , Hellstrom Lisa , Svedberg Agneta , Tiberg Fredrik

Background: Somatostatin receptor ligands (SRLs) are first-line standard-of-care therapies for gastroenteropancreatic neuroendocrine tumours (GEP-NETs), showing efficacy in tumour and symptom control with an established safety profile. However, disease progression may occur despite standard-dose SRL treatment, requiring more aggressive and toxic treatments. Retrospective/non-randomized data suggest higher-dose SRLs may benefit patients with GEP-NETs who do not respond to stand...

ea0089t7 | Trials In Progress | NANETS2022

Methodology of the SORENTO Clinical Trial: Assessing Efficacy and Safety of High Exposure Octreotide Subcutaneous Depot in Patients with GEP-NET

Singh, MD Simron , Capdevila, MD, PhD Jaume , Ang Chan, MD Jennifer , de Herder, MD Wouter , Ferone, MD, PhD Diego , Halperin, MD Daniel , Mailman, MBA Josh , Hellstrom, MSc Lisa , Svedberg, MSc, MBA Agneta , Tiberg, PhD Fredrik

Background: Somatostatin analogues (SSAs) are first-line standard of care therapies for gastroenteropancreatic neuroendocrine tumors (GEP-NET), showing efficacy in tumor/symptom control with an established safety profile. Yet, disease progression may occur despite standard-dose SSA treatment, requiring more aggressive and toxic therapies. Retrospective/non-randomized data suggest higher-dose SSAs may benefit patients with GEP-NET who do not respond to standard-dose treatment a...