ea0088006 | Abstracts | BES2022
Samal Bissenova
, Darcy Ellis
, Aisha Callebaut
, Guy Eelen
, Rita Derua
, Mijke Buitinga
, Chantal Mathieu
, Conny Gysemans
, Lut Overbergh
Background and aims: Type 1 diabetes (T1D) is a chronic autoimmune disease, characterized by T-cell mediated destruction of the pancreatic insulin-producing beta-cells. Neutrophils, cells of the innate immune system, have been shown to infiltrate the pancreas and undergo neutrophil extracellular trap (NET) formation (NETosis). However, little is known about the involvement of neutrophils and specifically the role of NETosis in the pathophysiology of the disease. Our aim was to...